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The epidemic dynamics of four major lineages of HIV-1 CRF01_AE strains after their introductions into China. AIDS Res Hum Retroviruses, February, 2016.
2016-03-11 | A A A  [print][close]

By Yang R1, Sun B2, Zeng H3,4, Li T5, Wang Y6.

 

Abstract

 

The epidemic of HIV-1 CRF01_AE in China was driven by multiple lineages of HIV-1 viruses introduced in the 1990s and increasing, it's important to investigate the epidemic status of them in china. In this study, we download all available CRF01_AE sequences (n=2931) from China and their associated epidemiological information in the Los Alamos HIV database for our analysis to explore their epidemic status in China. The results showed there were 11 distinct clusters of CRF01_AE strains in China, four major clusters which accounted for 80.0% (1793/2241) of Chinese CRF01_AE strains in total had led a real epidemic. Cluster 1 and 2 were epidemic among heterosexuals and IDUs in southern and southwestern China, while cluster 3 and 4 were predominant among homosexuals in eastern and central China and northeastern China, respectively. HIV-1 CRF01_AE strains detected in heterosexuals had the most complex characteristic, underscoring its important role in the occurrence of multiple CRF01_AE lineages. Furthermore, epidemic history reconstruction analysis using the birth-death SIR package revealed that the four clusters had gone through varying epidemic stages. Cluster 2 and 3 were near the peak of the local epidemic, while cluster 1 and 4 were just in the very early stage of their epidemic. The epidemic status of CRF01_AE clusters in the future are mainly determined by the effect of prevention and control. Our study provides new insights into the understanding of the epidemic dynamic of CRF01_AE in China.

 

·         1wuhan institute of virology,CAS, Research Group of HIV Molecular Epidemiology & Virology, Wuhan, China ; ryang@wh.iov.cn.

·         2wuhan institute of virology,CAS, Research Group of HIV Molecular Epidemiology & Virology , The State Key Laboratory of Virology, Wuhan Instituteof Virology, Chinese Academy of Sciences , Xiaohongshan 44 , Wuhan, China , 430071 ; sunbl@wh.iov.cn.

·         3wuhan institute of virology,CAS, Research Group of HIV Molecular Epidemiology & Virology, Wuhan, China.

·         4Guangdong Institute of Microbiology, Guangzhou, Guangdong, China ; zenghy@aliyun.com.

·         5wuhan institute of virology,CAS, Research Group of HIV Molecular Epidemiology & Virology, Wuhan, China ; lttwhbds@gmail.com.

·         6wuhan institute of virology,CAS, Research Group of HIV Molecular Epidemiology & Virology , The State Key Laboratory of Virology, Wuhan Instituteof Virology, Chinese Academy of Sciences , Xiaohongshan 44 , Wuhan, China , 430071 ; wangy@wh.iov.cn.

 

The epidemic dynamics of four major lineages of HIV-1 CRF01_AE strains after their introductions into China.

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