Gengfu XIAO

Title: Principal Investigator E-mail:




1. Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, Shi Z, Hu Z*, Zhong W*, Xiao G*. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar; 30(3):269-271.

2. Dai W, Zhang B, Jiang XM, Su H, Li J, Zhao Y, Xie X, Jin Z, Peng J, Liu F, Li C, Li Y, Bai F, Wang H, Cheng X, Cen X, Hu S, Yang X, Wang J, Liu X, Xiao G, Jiang H, Rao Z, Zhang LK, Xu Y, Yang H, Liu H. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science. 2020 Jun 19; 368(6497):1331-1335.

3.  Jin Z, Du X, Xu Y, Deng Y, Liu M, Zhao Y, Zhang B, Li X, Zhang L, Peng C, Duan Y, Yu J, Wang L, Yang K, Liu F, Jiang R, Yang X, You T, Liu X, Yang X, Bai F, Liu H, Liu X, Guddat LW, Xu W, Xiao G, Qin C, Shi Z, Jiang H, Rao Z, Yang H. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020 Jun; 582(7811):289-293.

4. Yang C, Pan X, Xu X, Cheng C, Huang Y, Li L, Jiang S, Xu W, Xiao G, Liu S. Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein. Signal Transduct Target Ther. 2020 Oct 6;5(1):220. doi: 10.1038/s41392-020-00325-1. PMID: 33024075; PMCID: PMC7538051.

5. Pan X, Zhou P, Fan T, Wu Y, Zhang J, Shi X, Shang W, Fang L, Jiang X, Shi J, Sun Y, Zhao S, Gong R, Chen Z*, Xiao G*. Immunoglobulin fragment F(ab')2 against RBD potently neutralizes SARS-CoV-2 in vitro. Antiviral Res. 2020 Oct; 182:104868

6. Zhang LK, Xin QL, Zhu SL, Wan WW, Wang W, Xiao G*. Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.  J Virol. 2016 Oct 28; 90(22):10259-10270.

7. Guo J, Jia X, Liu Y, Wang S, Cao J, Zhang B, Xiao G, Wang W. Inhibition of Na+/K+ ATPase blocks Zika virus infection in mice. Commun Biol. 2020 Jul 15;3(1):380. doi: 10.1038/s42003-020-1109-8. PMID: 32669655; PMCID: PMC7363852.

8. Wan W, Zhu S, Li S, Shang W, Zhang R, Li H, Liu W, Xiao G, Peng K, Zhang L. High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2. ACS Infect Dis. 2020 Nov 12:acsinfecdis.0c00486. doi: 10.1021/acsinfecdis.0c00486. Epub ahead of print. PMID: 33183004; PMCID: PMC7671101.

9. Pan X, Wu Y, Wang W, Zhang L, Xiao G. Development of horse neutralizing immunoglobulin and immunoglobulin fragments against Junín virus. Antiviral Res. 2020 Feb;174:104666. doi: 10.1016/j.antiviral.2019.104666. Epub 2019 Nov 21. PMID: 31760108; PMCID: PMC7114285.

10. Zhou LK, Zhou Z, Jiang XM, Zheng Y, Chen X, Fu Z, Xiao G, Zhang CY, Zhang LK, Yi Y. Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients. Cell Discov. 2020 Aug 5;6:54. doi: 10.1038/s41421-020-00197-3. PMID: 32802404; PMCID: PMC7406496.

11. Cao J, Zhang G, Zhou M, Liu Y, Xiao G, Wang W. Characterizing the Lassa Virus Envelope Glycoprotein Membrane Proximal External Region for Its Role in Fusogenicity. Virol Sin. 2020 Sep 8. doi: 10.1007/s12250-020-00286-3. Epub ahead of print. PMID: 32897505.

12. Zhu S, Wan W, Zhang Y, Shang W, Pan X, Zhang LK, Xiao G. Comprehensive Interactome Analysis Reveals that STT3B Is Required for N-Glycosylation of Lassa Virus Glycoprotein. J Virol. 2019 Nov 13;93(23):e01443-19. doi: 10.1128/JVI.01443-19. PMID: 31511384; PMCID: PMC6854512.