Title: Principal Investigator E-mail: df@wh.iov.cn




1: Zhang Y, Huang K, Wang T, Deng F, Gong W, Hui X, Zhao Y, He X, Li C, Zhang Q, Chen X, Lv C, Lin X, Yang Y, Sun X, Shi Z, Chen H, Zou Z, Jin M. SARS-CoV-2 rapidly adapts in aged BALB/c mice and induces typical pneumonia. J Virol. 2021 Mar 10:JVI.02477-20. doi: 10.1128/JVI.02477-20. Epub ahead of print. PMID:



2: Chen T, Duan X, Hu H, Shang Y, Hu Y, Deng F, Wang H, Wang M, Hu Z. Systematic Analysis of 42 Autographa Californica Multiple Nucleopolyhedrovirus Genes Identifies An Additional Six Genes Involved in the Production of Infectious Budded Virus. Virol Sin. 2021 Mar 8. doi: 10.1007/s12250-021-00355-1. Epub ahead of print. PMID: 33683665.


3: Moming A, Shi S, Shen S, Qiao J, Yue X, Wang B, Ding J, Hu Z, Deng F, Zhang Y, Sun S. Fine mapping epitope on Glycoprotein-Gn from Severe Fever with Thrombocytopenia Syndrome Virus. PLoS One. 2021 Mar 2;16(3):e0248005. doi: 10.1371/journal.pone.0248005. PMID: 33651850; PMCID: PMC7924767.


4: Tu D, Shu J, Wu X, Li H, Xia Z, Zhang Y, Fang Y, Shen S, Guan W, Wang H, Huang Z, Wang G, Zhou X, Deng F. Immunological detection of serum antibodies in pediatric medical workers exposed to varying levels of SARS-CoV-2. J Infect. 2021 Jan;82(1):159-198. doi: 10.1016/j.jinf.2020.07.023. Epub 2020 Jul 25. PMID: 32721505; PMCID: PMC7382336.


5: He L, Shao W, Li J, Deng F, Wang H, Hu Z, Wang M. Systematic analysis of nuclear localization of Autographa californica multiple nucleopolyhedrovirus proteins. J Gen Virol. 2021 Jan 18. doi: 10.1099/jgv.0.001517. Epub ahead of print. PMID: 33459587.


6: Shi J, Shen S, Wu H, Zhang Y, Deng F. Metagenomic Profiling of Viruses Associated with Rhipicephalus microplus Ticks in Yunnan Province, China. Virol Sin. 2021 Jan 5. doi: 10.1007/s12250-020-00319-x. Epub ahead of print. PMID: 33400089.


7: Mo Q, Xu Z, Deng F, Wang H, Ning YJ. Host restriction of emerging high-pathogenic bunyaviruses via MOV10 by targeting viral nucleoprotein and blocking ribonucleoprotein assembly. PLoS Pathog. 2020 Dec 7;16(12):e1009129. doi: 10.1371/journal.ppat.1009129. PMID: 33284835; PMCID: PMC7746268.


8: Min YQ, Mo Q, Wang J, Deng F, Wang H, Ning YJ. SARS-CoV-2 nsp1: Bioinformatics, Potential Structural and Functional Features, and Implications for Drug/Vaccine Designs. Front Microbiol. 2020 Sep 29;11:587317. doi: 10.3389/fmicb.2020.587317. PMID: 33133055; PMCID: PMC7550470.


9: Yuan C, Wu J, Peng Y, Li Y, Shen S, Deng F, Hu Z, Zhou J, Wang M, Zou Z. Transcriptome analysis of the innate immune system of Hyalomma asiaticum. J Invertebr Pathol. 2020 Nov;177:107481. doi: 10.1016/j.jip.2020.107481. Epub 2020 Oct 6. PMID: 33035534.


10: Zhang ZR, Zhang YN, Li XD, Zhang HQ, Xiao SQ, Deng F, Yuan ZM, Ye HQ, Zhang B. A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2. Signal Transduct Target Ther. 2020 Oct 3;5(1):218. doi: 10.1038/s41392-020-00343-z. PMID: 33011739; PMCID: PMC7532339.


11: Wu X, Li M, Zhang Y, Liang B, Shi J, Fang Y, Su Z, Li M, Zhang W, Xu L, Wang J, Wu Q, Tang S, Wang H, Zhang T, Peng C, Zheng X, Deng F, Shen S. Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes. Virol Sin. 2020 Sep 22. doi: 10.1007/s12250-020-00289-0. Epub ahead of print. PMID: 32960400.


12: Mu J, Fang Y, Yang Q, Shu T, Wang A, Huang M, Jin L, Deng F, Qiu Y, Zhou X. SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2. Cell Discov. 2020 Sep 15;6:65. doi: 10.1038/s41421-020-00208-3. PMID: 32953130; PMCID: PMC7490572.


13: Zhang L, Liu J, Cao R, Xu M, Wu Y, Shang W, Wang X, Zhang H, Jiang X, Sun Y, Hu H, Li Y, Zou G, Zhang M, Zhao L, Li W, Guo X, Zhuang X, Yang XL, Shi ZL, Deng F, Hu Z, Xiao G, Wang M, Zhong W. Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro. Virol Sin. 2020 Dec;35(6):776-784. doi: 10.1007/s12250-020-00288-1. Epub 2020 Sep 10. PMID:

32910347; PMCID: PMC7481761.


14: Wang J, Liu X, Zhu Q, Wu Q, Tang S, Zhang L, Fan Z, Hu Z, Wang H, Deng F, Shen S. Identification, Isolation, and Characterization of an Ectromelia Virus New Strain from an Experimental Mouse. Virol Sin. 2020 Jul 21. doi: 10.1007/s12250-020-00263-w. Epub ahead of print. PMID: 32696398.


15: Zheng X, Wang H, Su Z, Li W, Yang D, Deng F, Chen J. Co-infection of SARS-CoV-2 and Influenza virus in Early Stage of the COVID-19 Epidemic in Wuhan, China. J Infect. 2020 Aug;81(2):e128-e129. doi: 10.1016/j.jinf.2020.05.041. Epub 2020 May 28. PMID: 32474045; PMCID: PMC7255712.


16: Min YQ, Ning YJ, Wang H, Deng F. A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination. J Biol Chem. 2020 Jul 10;295(28):9691-9711. doi: 10.1074/jbc.RA120.013973. Epub 2020 May 29. PMID: 32471869; PMCID: PMC7363118.


17: Zhang H, Kuang W, Chen C, Shang Y, Ma X, Deng F, Wang H, Wang M, Hu Z. Per Os Infectivity Factor 5 Identified as a Substrate of P33 in the Baculoviral Disulfide Bond Formation Pathway. J Virol. 2020 Jul 16;94(15):e00615-20. doi: 10.1128/JVI.00615-20. PMID: 32434885; PMCID:



18: Wang X, Cao R, Zhang H, Liu J, Xu M, Hu H, Li Y, Zhao L, Li W, Sun X, Yang X, Shi Z, Deng F, Hu Z, Zhong W, Wang M. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020 May 2;6:28. doi: 10.1038/s41421-020-0169-8. PMID: 32373347; PMCID: PMC7195821.


19: Wang P, Liu L, Liu A, Yan L, He Y, Shen S, Hu M, Guo Y, Liu H, Liu C, Lu Y, Wang P, Deng F, Rao Z, Lou Z. Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation. Nat Microbiol. 2020 Jun;5(6):864-871. doi: 10.1038/s41564-020-0712-2. Epub 2020 Apr 27. PMID: 32341479.


20: Ren F, Zhou M, Deng F, Wang H, Ning YJ. Combinatorial Minigenome Systems for Emerging Banyangviruses Reveal Viral Reassortment Potential and Importance of a Protruding Nucleotide in Genome "Panhandle" for Promoter Activity and Reassortment. Front Microbiol. 2020 Apr 8;11:599. doi: 10.3389/fmicb.2020.00599. PMID: 32322247; PMCID: PMC7156889.


21: Min YQ, Shi C, Yao T, Feng K, Mo Q, Deng F, Wang H, Ning YJ. The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action. ACS Infect Dis. 2020 May 8;6(5):857-870. doi: 10.1021/acsinfecdis.9b00492. Epub 2020 Mar 20. PMID: 32167734.


22: Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 Mar;579(7798):270-273. doi: 10.1038/s41586-020-2012-7. Epub 2020 Feb 3. PMID: 32015507; PMCID: PMC7095418.


23: Shi J, Li W, Wang Y, Chen Q, Deng F. Meta-Transcriptome Profiling of Novel Invasive Pest Spodoptera frugiperda in Yunnan, China. Virol Sin. 2020 Apr;35(2):240-244. doi: 10.1007/s12250-019-00188-z. Epub 2020 Jan 8. PMID: 31916023; PMCID: PMC7198670.


24: Li Y, Hu L, Chen T, Chang M, Deng F, Hu Z, Wang H, Wang M. Host AAA+ ATPase TER94 Plays Critical Roles in Building the Baculovirus Viral Replication Factory and Virion Morphogenesis. J Virol. 2020 Feb 28;94(6):e01674-19. doi: 10.1128/JVI.01674-19. PMID: 31896597; PMCID: PMC7158741.


25: Liu D, Guo S, Zou M, Chen C, Deng F, Xie Z, Hu S, Wu L. A dengue fever predicting model based on Baidu search index data and climate data in South China. PLoS One. 2019 Dec 30;14(12):e0226841. doi: 10.1371/journal.pone.0226841. PMID: 31887118; PMCID: PMC6936853.


26: Sun QL, Li Y, Ni LQ, Li YX, Cui YS, Jiang SL, Xie EY, Du J, Deng F, Dong CX. Structural characterization and antiviral activity of two fucoidans from the brown algae Sargassum henslowianum. Carbohydr Polym. 2020 Feb 1;229:115487. doi: 10.1016/j.carbpol.2019.115487. Epub 2019 Oct 20. PMID: 31826428.


27: Wang J, Yang M, Xiao H, Huang GH, Deng F, Hu Z. Genome Analysis of Dasineura jujubifolia Toursvirus 2, A Novel Ascovirus. Virol Sin. 2020 Apr;35(2):134-142. doi: 10.1007/s12250-019-00177-2. Epub 2019 Nov 29. PMID: 31784872; PMCID: PMC7198669.


28: Liu X, Wang H, Liu X, Li Y, Chen J, Zhang J, Wang X, Shen S, Wang H, Deng F, Wang M, Guan W, Hu Z. Genomic and transcriptional analyses of novel parvoviruses identified from dead peafowl. Virology. 2020 Jan 2;539:80-91. doi: 10.1016/j.virol.2019.10.013. Epub 2019 Oct 31. PMID: 31706163.