Rongge YANG

Title: Principal Investigator E-mail:



1.   Zhang Y, Luo Y, Li Y, Zhang Y, Wu W, Peng H, Han L, Chen Y, Ruan L, Yang R*. (2020). Genetic diversity, complicated recombination and deteriorating drug resistance among HIV-1 infected individuals in Wuhan, China. AIDS Res. Hum. Retroviruses. 2020. doi: 10.1089/AID.2020.0142.

2.   Wang H, Yuan T, Li T, Li Y, Qian F, Zhu C, Liang S, Hoffmann D, Dittmer U, Sun B, Yang R*. (2018). Evaluation of susceptibility of HIV-1 CRF01_AE variants to neutralization by a panel of broadly neutralizing antibodies. Archives of Virology. 2018. 163(12):3303-3315.

3.   Shu Z, Chen Y, Abudureyimu A, Li T, Yuan T, Ma J, Li X, Ma X, Jang C, Bao G, Sun B, Yang R*. (2018). Surveillance of HIV-1 drug resistance in Xinjiang: high prevalence of K103N in treatment-naive individuals. Archives of Virology. 2018. 163 (8): 2111-2119. doi: 10.1007/s00705-018-3825-7.

4.   Yan Y, Li CH, Sun B, Yang R*. (2018). DCAF1 is involved in HCV replication through regulation of miR-122. Archives of Virology. 2018. 163(4):977-985.

5.   Yanpeng Li, Binlian Sun, Stefan Esser, Heiko Jessen, Hendrik Streeck, Marek Widera, Rongge Yang, Ulf Dittmer, Kathrin Sutter. (2017). Expression Pattern of Individual IFNA Subtypes in Chronic HIV Infection. J Interferon Cytokine Res. 2017. 37-12: 541-549.

6.   Li T, Qian F, Yuan T, Xu W, Zhu L, Huang J, Wang H, Zhu Y, Wang Y, Li X, Gu S, Tan Z, Chen H, Luo X, Zhu W, Lu W, Xu P, Li M, Chen Y, Gao Y, Yang R, Zhu C, Sun B. (2017). Drug resistance mutation profiles of the drug-naive and first-line regimen-treated HIV-1-infected population of Suzhou, China. Virologica Sinica. 2017. 32 (4): 271-279. doi: 10.1007/s12250-017-4002-y.

7.   Xiaolin Wang, Xiang He, Ping Zhong, Yongjian Liu, Tao Gui, Dijing Jia, Hanping Li, Jianjun Wu, Jin Yan, Dianmin Kang, Yang Han, Taisheng Li, Rongge Yang, Xiaoxu Han, Lin Chen, Jin Zhao, Hui Xing, Shu Liang, Jianmei He, Yansheng Yan, Yile Xue, Jiafeng Zhang, Xun Zhuang, Shujia Liang, Zuoyi Bao, Tianyi Li, Daomin Zhuang, Siyang Liu, Jingwan Han, Lei Jia, Jingyun Li, Lin Li. (2017). Phylodynamics of major CRF01_AE epidemic clusters circulating in mainland of China. Scientific Reports. 2017. 24; 7-1: 6330.

8.   Tingting Li, Binlian Sun*, Yanyan Jiang, Haiyan Zeng and Yanpeng Li, Yang R*. (2017). The changes of positive selection within env gene of HIV-1 B’, CRF07_BC and CRF08_BC from china over time. Current HIV Research, 2017, 15, 1-7

9.   Yuan T, Yao W, Tokunaga K, Yang R*, Sun B. (2016). An HIV-1 capsid binding protein TRIM11 accelerates viral uncoating. Retrovirology. 2016. 13:72.1-14.

10.  Sun B, Yang R, Mallardo. (2016). Roles of microRNAs in HIV-1 replication and latency. MicroRNA. 2016. 5-2. 120-123.

11.  Luo F, Chen T, Liu J, Shen X, Zhao Y, Yang R*, Zhang X*. (2016). Ficolin-2 recognizes HIV surface carbohydrates and blocks the viral infection. Virologica Sinica. 2016. 31-5. 406-414.

12.  Yan Y, Huang F, Yuan T, Sun B, Yang R*. (2016). HIV-1 Vpr Increases HCV Replication through VprBP in Cell Culture. VIrus Research. 2016. 223-2. 153-160.

13. Li Y, Wang Y, Song J, Sun B, Yang R*. (2016). The V1 region of gp120 is preferentially selected during simian immunodeficiency virus/human immunodeficiency virus transmission and is indispensable for envelope function. Virologica Sinica. 2016. 31. 207-218.

14. Zeng H, Li T, Wang Y, Sun B, Yang R*. (2016). The epidemic dynamics of four major lineages of HIV-1 CRF01_AE strains after their introductions into China. AIDS Res. Hum. Retroviruses. 2016. 32(5):420-6.

15. Soo-Yon Rhee, Jose Luis Blanco, Michael R. Jordan, Jonathan Taylor, Philippe Lemey, Vici Varghese, Raph L. Hamers, Silvia Bertagnolio, Tobias F. Rinke de Wit, Avelin F. Aghokeng, Jan Albert, Radko Avi, Santiago Avila-Rios, Pascal O. Bessong, James I. Brooks, Zabrina L. Brumme, Michael P. Busch, Hermann Bussmann, Marie-Laure Chaix, Bum Sik Chin, Toni T. D'Aquin, Cillian F. De Gascun, Anne Derache, Diane Descamps, Alaka K. Deshpande, Cyrille F. Djoko, ESAR, Susan H. Eshleman, Herve Fleury, Pierre Frange, Seiichiro Fujisaki, P Richard Harrigan, Junko Hattori, Africa Holguin, Gillian M. Hunt, Hiroshi Ichimura, David Katzenstein, Sasisopin Kiertiburanaku, Jerome H. Kim, Sung Soon Kim, Yanpeng Li, Irja Lutsar, Lynn Morris, Nicaise Ndembi, Kee Peng NG, Ramesh S. Paranjape, Martine Peeters, Mario Poljak, Matt A. Price, Manon L. Ragonnet-Cronin, Gustavo Reyes-Terán, Morgane Rolland, Sunee Sirivichayakul, Davey M. Smith, Marcelo A. Soares, Vincent V. Soriano, Deogratius Ssemwanga, Maja Stanojevic, Mariane A. Stefani, Wataru Sugiura, Somnuek Sungkanuparph, Amilcar Tanuri, Kok Keng Tee, Hong-Ha M. Truong, Nicole Vidal, Chunfu Yang, Rongge Yang, Gonzalo Yebra, John P.A. Ioannidis, Anne-Mieke Vandamme,  Robert W. Shafer1. (2015). Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: an Individual Patient and Sequence-level Meta-Analysis. PLoS Med. 2015. 12(4): e1001810. doi:10.1371/ journal. pmed. 1001810

16. Qiu H, Huang F, Gong J, Xiao H, Sun B, Yang R*. (2015). TRIM22 can activate the noncanonical NF-κB pathway by affecting IKKα. J Recept Signal Transduct Res. 2015. 35(4): 289-94.

17. Zhou D, Wang Y, Tokunaga K, Huang F, Sun B, Yang R*. (2015). The HIV-1 accessory protein Vpr induces the degradation of the anti-HIV-1 agent APOBEC3G through a VprBP-mediated proteasomal pathway. VIrus Research. 2015. 195:25-34.

18. Yuan T, Yao W, Sun B, Yang R*. (2014). The human antiviral factor TRIM11 is under the regulation of HIV-1 Vpr. PLoS ONE. 2014. 9(8):e104269.

19. Li Y, Wang Y, Sun B, Yang R*. (2014). Researchers should use more data, not just the HIV sequence compendium, for epidemiology and other HIV research. AIDS Res. Hum. Retroviruses. 2014 30(10): 933-5.

20. Zhang W, Wang Y, Yu K, Duan J, Yao W, Wang Y, Yang R, Yang G. (2014). Associated changes in the transcription levels of IL-17A and tight junction-associated genes in the duodenal mucosa of rhesus macaques repeatedly exposed to simian/human immunodeficiency virus. Exp Mol Pathol. 2014. 97(2):225-233.

21. Zeng H, Sun B, Li L, Li Y, Liu Y, Xiao Y, Jiang Y, Yang R*. (2014). Reconstituting the epidemic history of mono lineage of HIV-1 CRF01_AE in Guizhou province, southern China. Infection, Geneticsand Evolution. 2014. 26:139-145.

22. Deng A, Chen C, Ishizaka Y, Chen X, Sun B, Yang R*. (2014). Human immunodeficiency virus type 1 Vpr increases hepatitis C virus RNA replication in cell culture. Virus research.  2014, 184: 93-102.

23. Dang S, Wang Y, Budeus B, Jens V, Yang R, Hoffmann D. (2014). Differential Selection in HIV-1 gp120 Between Subtype B and East Asian Variant B'. Virologica Sinica. 2014. 29(1):40-7.

24. Li L, Sun B, Zeng H, Sun Z, Sun G, Yang R*. (2014). Relatively High Prevalence of Drug Resistance among Antiretroviral-Naive Patients from Henan, Central China. AIDS Res Hum Retroviruses. 2014. 30(2):160-4.

25.  Huang L, Kusagawa S, Zeng H, Yang G, Sun B, Miura T, Yang R*. (2014). Development of a Novel Rhesus Macaque Model with an Infectious R5 Simian-Human Immunodeficiency Virus Encoding HIV-1 CRF08_BC env. Journal of Medical Primatology. 2014. 43(1):11-21.

26. Li Y, Zeng H, Jiang Y, Sun B, Yang R*. (2013). Does HIV evolve towards a more adaptive state similar to that of simian immunodeficiency virus? AIDS. 2013. 27(18): 2965-7.

27. Zeng H, Sun B, Yang R*. (2013). The nomenclature of a new HIV circulating recombinant form should be cautious. AIDS. 2013. 27(16):2663-4.

28. Wang Y, Rawi R, Hoffmann D, Sun B, Yang R*. (2013). Inference of global HIV-1 sequence patterns and preliminary feature analysis. Virologica Sinica. 2013. 28(4):228-38.

29. Qiu H, Huang F, Xiao H, Sun B, Yang R*. (2013). TRIM22 inhibits the TRAF6-stimulated NF-κB pathway by targeting TAB2 for degradation. Virologica Sinica. 2013. 28(4):209-15.

30. Li X, Ning C, He X, Yang Y, Li F, Xing H, Hong K, Yang R, Shao Y. (2013). Genome Sequences of a Novel HIV-1 Circulating Recombinant Form (CRF61_BC) Identified among Heterosexual in China. Genome Announcements. 2013. 27. 1(3). pii: e00326-13. doi: 10.1128/genomeA.00326-13.

31. Li X, Ning C, He X, Yang Y, Xing H, Hong K, Shao Y, Yang R*. (2013). Near Full-Length Genome Sequence of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/CRF07_BC) Identified among MSM in Jilin, China. AIDS Res Hum Retroviruses. 2013. 29(12):1604-8.

32. Ning C, Li X, He X, Yang Y, Xing H, Hong K, Yang R, Shao Y. (2013). Near Full-length Genome Identification of a Novel HIV-1 B’/C Recombinant Isolate JL100091 in Jilin, China. AIDS Res Hum Retroviruses. 2013. 29(12):1604-8.

33. Chen C, Pan D, Deng A, Huang F, Sun B, Yang R*. (2013). DNA methyltransferases 1 and 3B are required for hepatitis C virus infection in cell culture. Virology. 2013. 441. 57-65.

34. Huang F, Xiao H, Sun B, Yang R*. (2013) Characterization of TRIM62 as a RING finger E3 ubiquitin ligase and its subcellular localization. BBRC 2013. 432. 208–213.

35. Wang Y, Reda Rawi, Christoph Wilms, Dominik Heider, Yang R*, Daniel Hoffmann. (2013). A small set of succinct signature patterns distinguishes Chinese and non-Chinese HIV-1 genomes. PLOS ONE. 2013.8-3. e58804.

36. Zeng H, Sun Z, Liang S, Li L, Jiang Y, Liu W, Sun B, Li J, Yang R*. (2012) Emergence of a New HIV-1 CRF01_AE Variant in 1 Guangxi, Southern China. AIDS Res Hum Retroviruses. 2012. 28(10):1352-6.

37. Fu B, Yang Rongge, Xia F, Li B, Ouyang X, Gao S, Wang L. (2012). Gender Difference of Kaposi’s sarcoma-associated Herpesvirus Infection in Population with Schistosomiasis in Rural China. Japanese Journal of Infectious Diseases. 2012. 65, 350-353.

38. Chen C, Qiu H, Gong J, Liu Q, Xiao H, Chen X, Sun B, Yang R*. (2012). (-)-Epigallocatechin-3-gallate inhibits the replication cycle of the hepatitis C virus. Archives of Virology. 2012. 157(7):1301-12.

39. Gong J, Wang X, Tong X, Shen X, Yang R*. (2011) Emergence trends of drug-resistant HIV-1 among drug-treated patients in former blood donors in Hubei, China: a three-year surveillance from 2004 to 2006. Virologica Sinica. 2011. 63(6):531-7.

40. Gong J, Shen XH, Qu H, Chen C, Yang R*. (2011) Rhesus monkey TRIM5 represses HIV-1 LTR promoter activity via negatively regulating TAK1/TAB1/TAB2/TAB3 complex mediated NF-B activation. Archives of Virology. 2011. 156(11):1997-2006.

41. Gong J, Shen XH, Qu H, Chen C, Yang R*. (2011) Rhesus monkey TRIM5α have distinct HIV-1 restriction 1 activity among different mammalian cell lines. Current microbiology. 2011. 63 (6): 531-537.

42. Gong J, Shen XH, Qu H, Chen C, Yang R*. (2011) Down-regulation of HIV-1 infection by inhibition 1 of the MAPK signaling pathway. Virologica Sinica. 2011, 26 (2):114-122.

43. Zhang W, Tong X, Nakasone T, Yue X, Yamamoto N, Liu X, Yang R*. (2011) Activity of superior interferon α against HIV-1 in severe combined immunodeficient mice reconstituted with human peripheral blood leukocytes. Chin Med J (Engl). 2011. 124(3): 396-400.

44. Li Y, Takebe Y, Yang J, Zhang W, Yang R*. (2011) High prevalence of HIV-1 subtype B' among heterosexuals in western Hubei, Central China: Bridging the epidemic into general population. AIDS Res Hum Retroviruses. 2011 27(9):1025-8

45. Wu Y, Liao Q, Yang R, Chen X, Chen X. (2011) A novel luciferase and GFP dual reporter virus for rapid and convenient evaluation of hepatitis C virus replication. Virus Res. 2011; 155(2): 406-14.

46. Zhang C, Ding N, Guo D, Chen K, Yang R*. (2010) Complex positive selection pressures drive the evolution of HIV-1 with different coreceptor tropisms. SCIENCE CHINA Life Sciences. 2010. 53(10). 1204-14.

47. Li Y, Tee KK, Liao H, Hase S, Uenishi R, Li XJ, Tsuchiura T, Yang R, Govindasamy S, Yong YK, Tan HY, Pybus OG, Kamarulzaman A, Takebe Y. (2010) Identification of a Novel Second-Generation Circulating Recombinant Form (CRF48_01B) in Malaysia: A Descendant of the Previously Identified CRF33_01B. J Acquir Immune Defic Syndr. 2010.54(2):129-36.

48. Han Q, Xu C, Wu C, Zhu W, Yang R, Chen X. (2009) Compensatory mutations in NS3 and NS5A proteins enhance the virus production capability of hepatitis C reporter virus. Virus Res. 2009 145(1): 63-73.

49. Tu Y, Wang M, Yao J, Zhu X, Pan P, Xing W, Zhang G, Yang R, Zheng Y, Jiang Y (2009) Surveillance for human immunodeficiency virus-1 subtypes and drug resistance among volunteer blood donors in Yunnan, China. Transfusion. 2009. 49(9): 1865-1873.

50. Guo D, Ding N, Xu Y, Guo H, Wei J, Wang J, He G, Yang R*, Zhang C. (2009) Near full-length genome characterization of an HIV-1 CRF01_AE strain in Jiangsu, China: evidence of two independent introduction from Fujian. AIDS Res Hum Retroviruses. 2009. 25 (6): 619-623.

51. Guo H, Guo D, Wei J, Yang H, Huan X, Tsui Stephen K, Yang R*, Zhang C. (2009) First detection of a novel HIV-1 CRF01_AE/07_BC recombinant among an epidemiologically linked cohort of IDUs in Jiangsu, China. AIDS Res Hum Retroviruses. 2009. 25 (4):463-467.

52. He W, Huang C, Li Y, Xie J, Yang R, Zhou P, Wang J. (2008) One-Step Label-Free Optical Genosensing Systemfor Sequence-Specific DNA Related to the Human Immunodeficiency Virus Based on the Measurements of Light Scattering Signals of Gold Nanorods. Anal. Chem., 2008. 80 (22), 8424-8430.

53. Ma Z, Hao P, Yao X, Liu C, Liu L, Yang R, Geng Y, Qiao W, Chen Q. (2008) Establishment of an indicator cell line to quantitate the infection of Bovine Foamy Virus. J Basic Microbiol. 2008 48(4): 278-83.

54. Deng X, Liu H, Shao Y, Rayner S, Yang R*. (2008) The Epidemic Origin and Molecular Properties of B', a Founder Strain of the HIV-1 Transmission in Asia. AIDS. 2008 22(14):1851-8.

55. Yao X, Han Q, Song J, Liang C, Wakita T. Yang R, Chen X. (2008) Baculovirus Mediated Production of Infectious Hepatitis C Virus in Human Hepatoma Cells Stably Expressing T7 RNA Polymerase. Mol Biotechnol. 2008 40(2):186-94.

56. Liu P, Xiang K, Tang H, Zhang W, Wang X, Tong X, Yang R*. (2008) Molecular Epidemiology of Human Immunodeficiency Virus Type 1 and Hepatitis C Virus in Former Blood Donors in Central China. AIDS Res Hum Retroviruses. 2008 24(1): 1-6.

57. Yang R*. (2007) HIV/AID Research in China: Chasing against Time. Virologica Sinica. 2007. 22-6. 417-8

58. Tan J, Kang X, Zhang W, Liu P, Tong X, Yang R*. (2007) Full-length clone and characterization of a human immunodeficiency virus type 1 subtype B' isolated from Hubei province, China. Chin Med J (Engl). 2007, 120(9): 831-833.

59. Saksena N, Wang B, Steain M, Yang R, Zhang L. (2005) Snapshot of HIV pathogenesis in China. Cell Res. 2005. Nov-Dec; 15 (11-12): 953-961.