Xinwen CHEN

Title: Principal Investigator E-mail: chenxw@wh.iov.cn

Education

Publications

1Zhao KT, Wu CC, Yao YY, Cao L, Zhang ZH, Yuan YF, Wang Y, RJ Pei, Chen JZ, Hu X, Zhou Y, Lu MJ and Chen XW. 2017. Ceruloplasmin inhibits the production of extracellular hepatitis B virions by targeting its middle surface protein. J GEN VIROL 98:1410–1421. DOI 10.1099/jgv.0.000794.


2. Su X, Liu SH, Zhang XW, Lam MS, Hu X, Zhou Y, Chen JZ, Wang Y, Wu CC, Shui GH, Lu MJ, Pei RJ, Chen XW. 2017. Requirement of Cytosolic Phospholipase A2 gamma in Lipid Droplet Formation. BBA-Mol Cell Biol L  DOI: 10.1016/j.bbalip.2017.03.007


3. Liu SH, Zhao KT, Su X, Lu L, Zhao H, Zhang X, Wang Y, Wu C, Chen J, Zhou Y, Hu X, Wang YY, Lu MJ, Chen XW, Pei RJ. 2017. MITA/STING and Its Alternative Splicing Isoform MRP Restrict Hepatitis B Virus Replication. PLoS One 12(1).


4. Mu JF, Zhang YL, Hu YY, Hu X, Zhou Y, Zhao H, Pei RJ, Wu CC, Chen JZ, Zhao H, Yang K, van Oers MM, Chen XW, Wang Y. 2016. Autographa californica Multiple Nucleopolyhedrovirus Ac34 Protein Retains Cellular Actin-Related Protein 2/3 Complex in the Nucleus by Subversion of CRM1-Dependent Nuclear Export. PLOS Pathog 12(11):e1005994.


5. Mu JF, Zhang YL, Hu YY, Hu X, Zhou Y, Chen XW and Wang Y. 2017. The role of viral protein Ac34 in nuclear relocation of subunits of the actin-related protein 2/3 complex. Virol Sin 31 (6): 480–489.


6. Chen JZ, Wang N, Dong M, Guo M, Zhao Y, Zhuo ZY, Zhang C, Chi XM, Pan Y, Jiang J, Tang H, Niu JQ, Yang DL, Li Z, Han X, Wang Q, Chen XW. 2015. The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection. Diabetes 64(12): 4088-4098.


7. Li SX, Zhao KT, Liu SH, Wu CC, Yao YX, Cao L, Hu X, Zhou Y, Wang Y, Pei RJ, Lu MJ, Chen XW. 2015. HBsAg sT123N mutation induces stronger antibody responses to HBsAg and HBcAg and accelerates in vivo HBsAg clearance. Virus Res 210: 119-125.


8. Wang Y, Zhang YL, Han SL, Hu X, Zhou Y, Mu JF, Pei RJ, Wu CC, Chen XW. 2015. Identification of a Novel Regulatory Sequence of Actin Nucleation Promoting Factor Encoded by Autographa californica Multiple Nucleopolyhedrovirus. J Biol Chem 290: 9533-9541.


9. Guo M, Pei RJ, Yang Q, Cao H, Wang Y, Wu CC, Chen JZ, Zhou Y, Hu X, Lu MJ, Chen XW. 2015. Phosphatidylserine-Specific Phospholipase A1 is involved in Hepatitis C Virus Assembly through NS2 Complex Formation. J Virol 89(4):2367-77.


10. Li HD, Zhu WD, Zhang LK, Lei HH, Wu XY, Guo L, Chen XW, Wang YL, Tang HR. 2015. The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment. Sci Rep.


11. Liang CY, Lan DD, Zhao SL, Liu LL, Xue YN, Zhang YL, Wang Y, Chen XW. 2015. The Ac124 protein is not essential for the propagation of Autographa californica multiple nucleopolyhedrovirus, but it is a viral pathogenicity factor. Arch Virol 160(1):275-8.


12. Pei RJ, Chen XW, Lu MJ. 2014. Control of hepatitis B virus replication by interferons and Toll-like receptor signaling pathways. World J Gastroenterol 20(33):11618-11629.


13. Chen JZ, Zhao Y, Zhang C, Chen HR, Feng J, Chi XM, Pan Y, Du J, Guo, M, Cao H, Chen HH, Wang ZL, Pei RJ, Wang Q, Pan L, Niu JQ, Chen XW, Tang H. 2014. Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice. Cell Res 24:1050–1066.


14. Wang ML, Wang J, Yin FF, Tan Y, Deng F, Chen XW, A. Jehle J, Vlak JM, Hu ZH, Wang HL. 2014. Unraveling the entry mechanism of baculoviruses and evolutionary implications. J Virol 88(4): 2301-2311.


15. Deng A, Chen C, Ishizaka Y, Chen XW, Sun BL, Yang RG. 2014. Human immunodeficiency virus type 1 Vpr increases hepatitis C virus RNA replication in cell culture. Virus Res 184:93-102.


16. Chen YZ, Wang SS, Yi ZH, Tian HB, Aliyari R, Li YH, Chen G, Liu P, Zhong J, Chen XW, Du PS, Su LS, Qin FX, Deng HY, Cheng GH. 2014. Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms. Sci Rep 4: 7242.


17. Mu JF, van Lent JW, Smagghe G, Wang Y, Chen XW, Vlak JM, van Oers MM. 2014. Live imaging of baculovirus infection of midgut epithelium cells: a functional assay of per os infectivity factors. J Gen Virol. 95: 2531-2539.


18. Pei RJ, Grund S, Verheyen J, Esser S, Chen XW, Lu MJ. 2014. Spontaneous reactivation of hepatitis B virus replication in an HIV coinfected patient with isolated anti-Hepatitis B core antibodies. Virol J 11: 9.


19. Cao L, Wu CC, Shi H, Gong ZJ, Zhang EJ, Wang H, Zhao KT, Liu SH, Li SX, Gao XZ, Wang Y, Pei RJ, Lu MJ, Chen XW. 2014. Coexistence of hepatitis B virus quasispecies enhances viral replication and the ability to induce host antibody and cellular immune responses. J Virol 88(15): 8656-66.


20. Zhu WD, Pei RJ, Jin R, Hu X, Zhou Y, Wang Y, Wu CC, Lu MJ, Chen XW. 2014. Nuclear Receptor 4 group A member 1 determines the hepatitis C virus entry efficiency through the regulation of cellular receptor and apolipoprotein E expression. J Gen Virol 95: 1510-1521.


21. Chen HH, Pei RJ, Zhu WD, Zeng R, Wang Y, Wang YY, Lu MJ, Chen XW. 2014. An Alternative Splicing Isoform of MITA Antagonizes MITA-Mediated Induction of Type I IFNs. J Immunol [published ahead of print].


22. Pei RJ, Qin B, Zhang XY, Zhu W, Kemper T, Ma ZY, Trippler M, Schlaak J, Chen XW, Lu MJ. 2014.  Interferon-Induced Proteins with Tetratricopeptide Repeats 1 and 2 Are Cellular Factors That Limit Hepatitis B Virus Replication. J Innate Immun 6:182-191.


23. Liu CHChen XW. 2014. A potential cellular host factor homologous to ZNF-136 can interact with truncated nonstructural protein 2 of hepatitis C virus.  Arch Virol 159(4): 785-789. 


24. Liang CY, Li M, Dai XJ, Zhao SL, Hou YL, Zhang YL, Lan DD, Wang Yun, Chen XW. 2013. Autographa californica multiple nucleopolyhedrovirus PK-1 is essential for nucleocapsid assembly. Virology 172(1-2):9-14.


25. Qin B, Pei RJ, He TT, Huang ZH, Pan GS, Tu CY, Lu MJ, Chen XW. 2013. Polymerase mutations rtN238R, rtT240Y and rtN248H of hepatitis B virus decrease susceptibility to adefovir. Chinese Sci Bull 58(15): 1760-1766.


26. Liu CH, Wang Y, Wu CC, Pei RJ, Song JH, Chen SY, Chen XW. 2013. Dioscin's antiviral effect in vitro. Virus Res 172(1-2): 9-14.


27. Qin B, Budeus B, Cao L, Wu CC, Wang Y, Zhang XY, Rayner S, Hoffmann D, Lu MJ, Chen XW. 2013. The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir. Antiviral Res 97(2):93-100.


28. Gan XN, Chen Z, Wang XZ, Wang DQ, Chen XW. 2012. Molecular cloning and characterization of interferon regulatory factor 1 (IRF-1), IRF-2 and IRF-5 in the chondrostean paddlefish Polyodon spathula and their phylogenetic importance in the Osteichthyes.  Dev Comp Immunol 36(1): 74-84.


29. Liang CY, de Lange J, Chen XW, van Oers MM, Vlak JM, Westenberg M. 2012. Functional analysis of two inhibitor of apoptosis (iap) orthologs from Helicoverpa armigera nucleopolyhedrovirus. Virus Res 165(1): 107-111.


30. Liu MM, Zhou L, He PL, Zhang YN, Zhou JY, Shen Q, Chen X W, Zuo JP, Li W, Ye DY. 2012. Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy.  Eur J Med Chem 52: 33-43.


31. Wang Q, Chen JZ, Wang Y, Han X, Chen XW. 2012. Hepatitis C virus induced a novel apoptosis-like death of pancreatic beta cells through a caspase 3-dependent pathway. PLoS ONE 7(6): e38522. 


32. Wu CC, Deng WY, Deng L, Cao L, Qin B, Li SX, Wang Y, Pei RJ, Yang DJ, Lu MJ, Chen XW. 2012. Amino Acid Substitutions at Positions 122 and 145 of Hepatitis B Virus Surface Antigen (HBsAg) Determine the Antigenicity and Immunogenicity of HBsAg and Influence In Vivo HBsAg Clearance.  J Virol 86(8): 4658-4669.


33. Xu S, Pei RJ, Guo M, Han QX, Lai J, Wang Y, Wu CC, Lu MJ, Chen XW. 2012. Cytosolic Phospholipase A2 Gamma Is Involved in Hepatitis C Virus Replication and Assembly. J Virol 86(23): 13025-13037.


34. Zhu WB, Wu CC, Deng WY, Pei RJ, Wang Y, Cao L, Qin B, Lu MJ, Chen XW. 2012. Inhibition of the HCV core protein on the immune response to HBV surface antigen and on HBV gene expression and replication in vivo.  PLoS ONE 7(9): e45146.


35. Yin Y, Wu CC, Song JH, Wang JZ, Zhang EJ, Liu HY, Yang DL, Chen XW, Lu MJ, Xu Y. 2011. DNA Immunization with Fusion of CTLA-4 to Hepatitis B Virus (HBV) Core Protein Enhanced Th2 Type Responses and Cleared HBV with an Accelerated Kinetic. PLoS ONE 6(7):e22524 


36. Bai HM, Wang Y, Li X, Mao HT, Li Y, Han SL, Shi ZL and Chen XW. 2011.  Isolation and Characterization of a Novel Alphanodavirus. Virol J  8: 311 


37. Gan XN, Wang DQ, Wang XZ, Chen XW. 2011. Cloning the interferon regulatory factor 1 gene in lungfish (Protopterus annectens) and its molecular evolution among sarcopterygians. Chinese Sci Bull 56(12): 1782-1786


38. Pei RJ, Chen HH, Lu L, Zhu WD, Beckebaum S, Cicinnati V, Lu MJ, Chen XW. 2011. Hepatitis C virus infection induces the expression of amphiregulin, a factor related to the activation of cellular survival pathways and required for efficient viral assembly. J Gen Virol 92(10): 2237-2248


39.Li CH, Ma LX, Chen XW. 2011. Interferon regulatory factor 3-CL, an isoform of IRF3, antagonizes activity of IRF3. Cell Mol Immunol 8: 67-74


40. Li YM, Chen JZ, Wu CC, Wang LD, Lu MJ, Chen XW. 2010. Hepatitis B virus/hepatitis C virus upregulate angiopoietin-2 expression through mitogen-activated protein kinase pathway. Hepatol Res 40(10): 1022-1033


41. Li K, Wang Y, Bai HM, Wang Q, Song JH, Zhou Y, Wu CC, Chen XW. 2010. The putative pocket protein binding site of Autographa californica Nucleopolyhedrovirus BV/ODV-C42 is required for virus-induced nuclear actin polymerization. J Virol 84(15):7857-7868


42. Zhu WB, Chang YZ, Wu CC, Han QX, Pei RJ, Lu MJ, Chen XW. 2010. Wild-type hepatitis C virus core inhibits the initiation of antigen-specific T- and B-cell immune responses in BALB/c mice. Clin Vaccine Immunol 17(7): 1139-1147


43. Wu CC, Zhang XY, Tian YJ, Song JH, Yang DL, Roggendorf M, Lu MJ, Chen XW. 2010. The significance of HBsAg subtype determinants aa 122 and 160 for the antigenicity and immunogenicity of HBsAg. J Gen Virol 91:483-492