Research Progress

[25-03-2019]Researchers provide a global view on how host cells respond to SFTSV infection

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus that causes severe fever with thrombocytopenia syndrome (SFTS). Since the first report in China in 2009, SFTSV has spread over China, South Korea and Japan, with a mortality rate reaching up to 30%. To establish successful infection, 90 SFTSV must manipulate host proteins to favor its own replication. Howe...

[15-01-2019]Scientists revealed the multistep SFTSV entry process and the dynamic virus–host interactions in...

The Bunyavirales is one of the largest groups of RNA viruses, which encompasses more than 350 members distributed among nine families. Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging bunyavirus in the genus Phlebovirus, was first identified in China in 2009, with a high case fatality rate of up to 30%.

[14-01-2019]Researchers revealed PIF complex formation and intracellular transport

Baculoviruses are rod-shaped, large dsDNA viruses that infect insects from the families Lepidoptera, Hymenoptera, and Diptera. Entry of baculovirus in host insects is mediated by a per os infectivity factor (PIF) complex on the envelope of occlusion-derived virus. The mechanism of PIF complex assembly is still largely unknown. Knowledge of the composition and structure of the PIF complex is fun...

[10-01-2019]Scientists Dissect Dynamic Uncoating of Individual Influenza Viruses in Infected Cells

During virus infection, uncoating is a key step to release the viral genome into host cells, and this step is an attractive antiviral target. However, virus uncoating, especially influenza A virus (IAV), which contains an unusual genome of eight segmented RNAs, has been a poorly understood process due to limitation in applicable methodology for detecting this transient and dynamic event.