Title: Principal Investigator E-mail: zlshi@wh.iov.cn
Education
1. Chen, J., Hu, B.J., Zhao, K., Luo, Y., Lin, H.F., Shi, Z.L*. (2021). Development of a MERS-CoV Replicon Cell Line for Antiviral Screening. Virol Sin, 1-6.
2. Wang, D., Jiang, A., Feng, J., Li, G., Guo, D., Sajid, M., Wu, K., Zhang, Q., Ponty, Y., Will, S., Liu, F., Yu, X., Li, S., Liu, Q., Yang, X-L., Guo, M., Li,X., Chen, M., Shi, Z-L., Lan, K.*, Chen, Y.,*, Zhou, Y*. (2021). The SARS-CoV-2 Subgenome Landscape and its Novel Regulatory Features. Molecular Cell, doi.org/10.1016/j.molcel.2021.02.036.
3. Hu, B.#, Guo, H.#, Zhou, P., Shi, Z.L*. (2021). Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol, 19(3):141-154.
4. Li, A.#, Ling, Y.#, Song, Z.Q.#, Cheng, X.B., Ding, L.F., Jiang, R.D., Fu, W.H., Liu, Y., Hu, H.L., Yuan, S.H., Chen, J., Zhu, C.S., Fan, J., Wang, J., Jin, Y.L., Zhang, M.M., Zhu, L.Y., Sun, P., Zhang, L.X., Qin, R., Zhang, W., Qiu, C.L., Shen, Y.Z., Zhang, L., Shi, Z.L., Zhao, C., Zhu, T.Y.*, Lu, H.Z.*, Zhang, X.Y.*, Xu, J.Q*. (2020). Early plasma IL-37 responses accompanied with low inflammatory cytokines correlate with benign clinical outcomes during SARS-CoV-2 infection. J Infect Dis, 223(4):568–580.
5. Zhou, P., Shi, Z.L*. (2021). SARS-CoV-2 spillover events. Science, 371(6525):120-122.
6. Luo, D.S., Li, B., Shen, X.R., Jiang, R.D., Zhu, Y., Wu, J., Fan, Y., Bourhy, H., Hu, B., Ge, X.Y., Shi, Z.L.*, Dacheux, L*. (2021). Characterization of Novel Rhabdoviruses in Chinese Bats. Viruses-Basel, 13(1):64.
7. Wang, Z-J.#, Zhang, H-J.#, Lu, J.#, Xu, K-W.#, Peng, C.#, Guo, J.#, Gao, X-X.#, Wan, X.#, Wang, W-H.#, Shan, C., Zhang, S-C., Wu, J., Yang, A-N., Zhu, Y., Xiao, A., Zhang, L., Fu, L., Si, H-R., Cai, Q., Yang, X-L., You, L., Zhou, Y-P., Liu, J., Pang, D-Q., Jin, W-P., Zhang, X-Y., Meng, S-L., Sun, Y-X., Desselberger, U., Wang, J-Z., Li, X-G., Duan, K., Li, C-G.*, Xu, M.*, Shi, Z-L.*, Yuan, Z-M.*, Yang, X-M.*, Shen, S*. (2020). Low toxicity and high immunogenicity of an inactivated vaccine candidate against COVID-19 in different animal models. Emerg Microbes Infect, 9(1):2606-2618.
8. Zhang, Q.#, Zhang, H.#, Gao, J.#, Huang, K., Yang, Y., Hui, X., He, X., Li, C., Gong, W., Zhang, Y., Zhao, Y., Peng, C., Gao, X., Chen, H., Zou, Z.*, Shi, Z.L.*, Jin, M*. (2020). A serological survey of SARS-CoV-2 in cat in Wuhan. Emerg Microbes Infect, 9(1):2013-2019.
9. Jiang, R.D., Li, B., Liu, X.L., Liu, M.Q., Chen, J., Luo, D.S., Hu, B.J., Zhang, W., Li, S.Y., Yang, X.L.*, Shi, Z.L*. (2020). Bat mammalian orthoreoviruses cause severe pneumonia in mice. Virology, 551:84-92.
10. Luo, Y.#, Chen, Y.#, Geng, R., Li, B., Chen, J., Zhao, K., Zheng, X.S., Zhang, W., Zhou, P., Yang, X.L., Shi, Z.L*. (2020). Broad Cell Tropism of SADS-CoV In Vitro Implies Its Potential Cross-Species Infection Risk. Virol Sin, 1-5.
11. Guo, H.#, Hu, B.J.#, Yang, X.L., Zeng, L.P., Li, B., Ouyang, S., Shi, Z.L*. (2020). Evolutionary Arms Race between Virus and Host Drives Genetic Diversity in Bat Severe Acute Respiratory Syndrome-Related Coronavirus Spike Genes. J Virol, 94(20):e00902-20.
12. Latinne, A.#, Hu, B.#, Olival, K.J., Zhu, G., Zhang, L., Li, H., Chmura, A.A., Field, H.E., Zambrana-Torrelio, C., Epstein, J.H., Li, B., Zhang, W., Wang, L.F., Shi, Z.L.*, Daszak, P*. (2020). Origin and cross-species transmission of bat coronaviruses in China. Nat Commun, 11(1):4235.
13. Shan, C.#*, Yao, Y.F.#, Yang, X.L.#, Zhou, Y.W.#, Gao, G., Peng, Y., Yang, L., Hu, X., Xiong, J., Jiang, R.D., Zhang, H.J., Gao, X.X., Peng, C., Min, J., Chen, Y., Si, H.R., Wu, J., Zhou, P., Wang, Y.Y., Wei, H.P., Pang, W., Hu, Z.F., Lv, L.B., Zheng, Y.T., Shi, Z.L.*, Yuan, Z.M*. (2020). Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques. Cell Res, 30(8):670-677.
14. Wang, C.#*, Xie, J.#, Zhao, L.#, Fei, X.#, Zhang, H.#, Tan, Y.#, Nie, X.#, Zhou, L.#, Liu, Z.#, Ren, Y., Yuan, L., Zhang, Y., Zhang, J., Liang, L., Chen, X., Liu, X., Wang, P., Han, X., Weng, X., Chen, Y., Yu, T., Zhang, X., Cai, J.*, Chen, R.*, Shi, Z.L.*, Bian, X.W*. (2020). Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients. EbioMedicine, 57:102833.
15. Jiang, R.D.#, Liu, M.Q.#, Chen, Y.#, Shan, C., Zhou, Y.W., Shen, X.R., Li, Q., Zhang, L., Zhu, Y., Si, H.R., Wang, Q., Min, J., Wang, X., Zhang, W., Li, B., Zhang, H.J., Baric, R.S., Zhou, P., Yang, X.L.*, Shi, Z.L*. (2020). Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2. Cell, 182(1):50-58.e8.
16. Yi, C.#, Sun, X.#, Ye, J.#, Ding, L., Liu, M., Yang, Z., Lu, X., Zhang, Y., Ma, L., Gu, W., Qu, A., Xu, J., Shi, Z.L.*, Ling, Z.*, Sun, B*. (2020). Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies. Cell Mol Immunol, 17(6):621-630.
17. Jin, Z.#, Du, X.#, Xu, Y.#, Deng, Y.#, Liu, M.#, Zhao, Y., Zhang, B., Li, X., Zhang, L., Peng, C., Duan, Y., Yu, J., Wang, L., Yang, K., Liu, F., Jiang, R., Yang, X., You, T., Liu, X., Yang, X., Bai, F., Liu, H., Liu, X., Guddat, L.W., Xu. W., Xiao, G., Qin, C., Shi, Z.L., Jiang, H.*, Rao, Z.*, Yang, H*. (2020). Structure of M pro from SARS-CoV-2 and discovery of its inhibitors. Nature, 582(7811):289-293.
18. Duan, K.#, Liu, B.#, Li, C.#, Zhang, H.#, Yu, T.#, Qu, J.#, Zhou, M.#, Chen, L.#, Meng, S., Hu, Y., Peng, C., Yuan, M., Huang, J., Wang, Z., Yu, J., Gao, X., Wang, D., Yu, X., Li, L., Zhang, J., Wu, X., Li, B., Xu, Y., Chen, W., Peng, Y., Hu, Y., Lin, L., Liu, X., Huang, S., Zhou, Z., Zhang, L., Wang, Y., Zhang, Z., Deng, K., Xia, Z., Gong, Q., Zhang, W., Zheng, X., Liu, Y., Yang, H., Zhou, D., Yu, D., Hou, J., Shi, Z.L., Chen, S., Chen, Z.*, Zhang, X.*, Yang, X*. (2020). Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci U S A, 117(17):9490-9496.
19. Zohaib, A., Saqib, M., Athar, M.A., Hussain, M.H., Sial, A.U.R., Tayyab, M.H., Batool, M., Sadia, H., Taj, Z., Tahir, U., Jakhrani, M.Y., Tayyab, J., Kakar, M.A., Shahid, M.F., Yaqub, T., Zhang, J.Y., Wu, Q.L., Deng, F., Corman, V.M., Shen, S., Khan, I., Shi, Z.L*. (2020). Crimean-Congo Hemorrhagic Fever Virus in Humans and Livestock, Pakistan, 2015-2017. Emerg Infect Dis, 26(4):773-777.
20. Zhou, P.#, Yang, X.L.#, Wang, X.G.#, Hu, B., Zhang, L., Zhang, W., Si, H.R., Zhu, Y., Li, B., Huang, C.L., Chen, H.D., Chen, J., Luo, Y., Guo, H., Jiang, R.D., Liu, M.Q., Chen, Y., Shen, X.R., Wang, X., Zheng, X.S., Zhao, K., Chen, Q.J., Deng, F., Liu, L.L., Yan, B., Zhan, F.X., Wang, Y.Y., Xiao, G.F., Shi, Z.L*. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798):270-273.
21. Jiang, S., Shi, Z.L., Shu, Y., Song, J., Gao, G.F., Tan, W., Guo, D*. (2020). A distinct name is needed for the new coronavirus. Lancet, 395(10228):949.
22. Zhang, W.#, Du, R.H.#, Li, B., Zheng, X.S., Yang, X.L., Hu, B., Wang, Y.Y., Xiao, G.F., Yan, B., Shi, Z.L.*, Zhou, P*. (2020). Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect, 9(1):386-389.
23. Li, B.#, Si, H.R.#, Zhu, Y., Yang, X.L., Anderson, D.E., Shi, Z.L., Wang, L.F.*, Zhou, P*. (2020). Discovery of Bat Coronaviruses through Surveillance and Probe Capture-Based Next-Generation Sequencing. mSphere, 5(1):pii: e00807-19.
24. Huang, Y., Wang, X., Yang, J., Lu, S., Lai, X.H., Jin, D., Pu, J., Huang, Y., Ren, Z., Zhu, W., Liang, H., Zhou, P., Shi, Z.L.*, Xu, J*. (2020). Apibacter raozihei sp. nov. isolated from bat feces of Hipposideros and Taphozous spp. Int J Syst Evol Microbiol, 70(1):611-617.
25. Onyuok, S.O.#, Hu, B.#, Li, B., Fan, Y., Kering, K., Ochola, G.O., Zheng, X.S., Obanda, V., Ommeh, S., Yang, X.L., Agwanda, B.*, Shi, Z.L*. (2019). Molecular Detection and Genetic Characterization of Novel RNA Viruses in Wild and Synanthropic Rodents and Shrews in Kenya. Front Microbiol, 10:2696.
26. Zhang, W.#, Zheng, X.S.#, Agwanda, B.#, Ommeh, S.#, Zhao, K., Lichoti, J., Wang, N., Chen, J., Li, B., Yang, X.L., Mani, S., Ngeiywa, K.J., Zhu, Y., Hu, B., Onyuok, S.O., Yan, B., Anderson, D.E., Wang, L.F., Zhou, P.*, Shi, Z.L*. (2019). Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels. Emerg Microbes Infect, 8(1):1528-1534.
27. Wang, N.#, Luo, C.M.#, Liu, H.Z., Yang, X.L., Hu, B., Zhang, W., Li, B., Zhu, Y., Zhu, G.J., Shen, X.R., Peng, C., Shi, Z.L*. (2019). Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus bats. Viruses-Basel, 11(4):379.
28. Fan, Y., Zhao, K., Shi, Z.L., Zhou, P*. (2019). Bat Coronaviruses in China. Viruses-Basel, 11(3):210.
29. Yang, X.L.#, Tan, C.W.#, Anderson, D.E., Jiang, R.D., Li, B., Zhang, W., Zhu, Y., Lim, X.F., Zhou, P., Liu, X.L., Guan, W., Zhang, L., Li, S.Y., Zhang, Y.Z., Wang, L.F.*, Shi, Z.L*. (2019). Characterization of a filovirus (Měnglà virus) from Rousettus bats in China. Nat Microbiol, 4(3):390-395.
30. Cui, J., Li, F., Shi, Z.L*. (2019). Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol, 17(3):181-192.
31. Wang, J.X.#, Yang, X.L.#, Liu, H.Z, Wang, L., Zhou, J.H., Han, X., Zhu, Y., Yang, W.H., Pan, H., Zhang, Y.Z.*, Shi, Z.L*. (2019). Prevalence of Wēnzhōu virus in small mammals in Yunnan Province, China. PLoS Negl Trop Dis, 13(2):e0007049.
32. Ommeh, S.#, Zhang, W.#, Zohaib, A.#, Chen, J.#, Zhang, H., Hu, B., Ge, X.Y., Yang, X.L., Masika, M., Obanda, V., Luo, Y., Li, S., Waruhiu, C., Li, B., Zhu, Y., Ouma, D., Odendo, V., Wang, L.F., Anderson, D.E., Lichoti, J., Mungube, E., Gakuya, F., Zhou, P., Ngeiywa, K.J., Yan, B., Agwanda, B.*, Shi, Z.L*. (2018). Genetic Evidence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Widespread Seroprevalence among Camels in Kenya. Virol Sin, 33(6):484-492.
33. Zohaib, A., Saqib, M., Athar, M.A., Chen, J., Sial, A.U., Khan, S., Taj, Z., Sadia, H., Tahir, U., Tayyab, M.H., Qureshi, M.A., Mansoor, M.K., Naeem, M.A., Hu, B.J., Khan, B.A., Ujjan, I.D., Li, B., Zhang, W., Luo, Y., Zhu, Y., Waruhiu, C., Khan, I., Yang, X.L., Sajid, M.S., Corman, V.M., Yan, B., Shi, Z.L*. (2018). Countrywide Survey for MERS-Coronavirus Antibodies in Dromedaries and Humans in Pakistan. Virol Sin, 33(5):410-417.
34. Luo, C-M., Wang N., Yang, X-L., Liu, H-Z., Zhang, W., Li, B., Hu, B., Peng, C., Geng, Q-B., Zhu, G-J., Li, F.*, Shi, Z-L*. (2018). Discovery of Novel Bat Coronaviruses in South China That Use the Same Receptor as Middle East Respiratory Syndrome Coronavirus. J Virol, 92(13):e00116-18.
35. Zhou, P.#, Fan, H.#, Lan, T.#, Yang, X-L, Shi, W-F, Zhang, W., Zhu. Y., Zhang, Y-W., Xie, Q-M., Mani, S., Zheng, X-S., Li, B., Li, J-M., Guo, H., Pei, G-Q., An, X-P., Chen J-W., Zhou, L., Mai, K-J., Wu, Z-X., Li, D., Anderson, D.E., Zhang, L-B., Li, S-Y., Mi, Z-Q., He, T-T., Cong, F., Guo, P-J., Huang, R., Luo, Y., Liu, X-L., Chen, J., Huang, Y., Sun, Q., Zhang, X-L-L., Wang, Y-Y., Xing, S-Z., Chen, Y-S., Sun, Y., Li, J., Daszak, P.*, Wang, L-F.*, Shi, Z-L.*, Tong, Y-G.*, Ma, J-Y*. (2018). Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin. Nature, 556(7700):255-258.
36. Xie, J., Li, Y., Shen, X., Goh, G., Zhu, Y., Cui, J., Wang, L-F., Shi, Z.L.*, Zhou, P*. (2018). Dampened STING-Dependent Interferon Activation in Bats. Cell Host Microbe, 23(3):297-301.
37. Wang, N., Li, S-Y., Yang, X-L., Huang, H-M., Zhang, Y-J., Guo, H., Luo, C-M., Miller, M., Zhu, G., Chmura, A.A., Hagan, E., Zhou, J-H., Zhang, Y-Z., Wang, L-F., Daszak, P., Shi, Z-L*. (2018). Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China. Virol Sin, 33(1):104-107.
38. Luo, Y., Li, B., Jiang, R-D., Hu, B-J., Luo, D-S., Zhu, G-J., Hu, B., Liu, H-Z., Zhang, Y-Z., Yang, X-L., Shi, Z-L*. (2018). Longitudinal Surveillance of Betacoronaviruses in Fruit Bats in Yunnan Province, China during 2009-2016. Virol Sin, 33(1):87-95.
39. Zeng, L.P., Ge, X.Y., Peng, C., Tai, W.B., Jiang, S.B., Du, L.Y.*, Shi, Z.L*. (2017). Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses. Sci China Life Sci, 60(12):1399-1402.
40. Hu, B.#, Zeng, L.P.#, Yang, X.L.#, Ge, X.Y., Zhang, W., Li, B., Xie, J.Z., Shen, X.R., Zhang, Y.Z., Wang, N., Luo, D.S., Zheng, X.S., Wang, M.N., Daszak, P., Wang, L.F., Cui, J.*, Shi, Z.L*. (2017). Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. PLoS Pathog, 13(11):e1006698.
41. Zhang, Q., Zeng, L.P., Zhou, P., Irving, A.T., Li, S., Shi, Z.L.*, Wang, L.F. (2017). IFNAR2-dependent gene expression profile induced by IFN-α in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection. PLoS One, 12(8):e0182866.
42. Ge, X.Y., Yang, W.H., Zhou, J.H., Li, B., Zhang, W., Shi, Z.L.*, Zhang, Y.Z*. (2017). Detection of alpha- and betacoronaviruses in rodents from Yunnan, China. Virol J, 14:98.
43. Tan, B., Yang, X.L., Ge, X.Y., Peng, C., Liu, H.Z., Zhang, Y.Z., Zhang, L.B., Shi, Z.L*. (2017). Novel bat adenoviruses with low G+C content shed new light on the evolution of adenoviruses. J Gen Virol, 98(4):739-748.
44. Waruhiu, C., Ommeh, S.*, Obanda, V., Agwanda, B., Gakuya, F., Ge, X.Y., Yang, X.L., Wu, L.J., Zohaib, A., Hu, B., Shi, Z.L*. (2017). Molecular detection of viruses in Kenyan bats and discovery of novel astroviruses, caliciviruses and rotaviruses. Virol Sin, 32(2):101-114.
45. Yang, X.L.#, Zhang, Y.Z.#, Jiang, R.D.#, Guo, H., Zhang, W., Li, B., Wang, N., Wang, L., Waruhiu, C., Zhou, J.H., Li, S.Y., Daszak, P., Wang, L.F. & Shi, Z.L*. (2017). Genetically Diverse Filoviruses in Rousettus and Eonycteris spp. Bats, China, 2009 and 2015. Emerg Infect Dis, 23(3):482-486.
46. Wang, B., Yang, X.L., Li, W., Zhu, Y., Ge, X.Y., Zhang, L.B., Zhang, Y.Z., Bock, C.T., Shi, Z.L*. (2017). Detection and genome characterization of four novel bat hepadnaviruses and a hepevirus in China. Virol J, 14(1):40.
47. Tan, B., Wu, L.J., Yang, X.L., Li, B., Zhang, W., Lei, Y.S., Yang, G.X., Chen, J., Chen, G., Wang, H.Z., Shi, Z.L*. (2016). Isolation and characterization of adenoviruses infecting endangered golden snub-nosed monkeys (Rhinopithecus roxellana). Virol J, 13:190.
48. Zeng, L.P., Gao, Y.T., Ge, X.Y., Zhang, Q., Peng, C., Yang, X.L., Tan, B., Chen, J., Chmura, A.A., Daszak, P. & Shi, Z.L*. (2016). Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. J Virol, 90(14): 6573-6582.
49. Tan, B., Yang, X.L., Ge, X.Y., Peng, C., Zhang, Y.Z., Zhang, L.B. & Shi, Z.L*. (2016). Novel bat adenoviruses with an extremely large E3 gene. J Gen Virol, 97(7):1625-1635.
50. Yang, X-L., Hu, B., Wang, B., Wang, M-N., Zhang, Q., Zhang, W., Wu, L-J., Ge, X-Y., Zhang, Y-Z., Daszak, P., Wang, L-F. & Shi, Z-L*. (2016). Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. J Virol, 90(6):3253-3256.
51. Wang, M.N., Zhang, W., Gao, Y.T., Hu, B., Ge, X.Y., Yang, X.L., Zhang, Y.Z. & Shi, Z.L*. (2016). Longitudinal surveillance of SARS-like coronaviruses in bats by quantitative real-time PCR. Virol Sin, 31(1):78-80.
52. Ge, X.Y.#, Wang, N.#, Zhang, W., Hu, B., Li, B., Zhang, Y.Z., Zhou, J.H., Luo, C.M., Yang, X.L., Wu, L.J., Wang, B., Zhang, Y., Li, Z.X. & Shi, Z.L*. (2016). Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft. Virol Sin, 31(1):31-40.
53. Shi, Z.L.*, Guo, D.*, Rottier, P.J.M*. (2016). Coronavirus: epidemiology, genome replication and the interactions with their hosts. Virol Sin, 31(1):1-2.
