Zhiming YUAN

Title: Principal Investigator E-mail: yzm@wh.iov.cn

Education

Publications
1. Chao Shan #*,Yan-Feng Yao , Xing-Lou Yang , Yi-Wu Zhou , Ge Gao , Yun Peng , Lian Yang , Xue Hu , Jin Xiong 1 , Ren-Di Jiang ,Hua-Jun Zhang , Xiao-Xiao Gao , Cheng Peng , Juan Min , Ying Chen , Hao-Rui Si , Jia Wu , Peng Zhou , Yan-Yi Wang ,Hong-Ping Wei , Wei Pang , Zheng-Fei Hu , Long-Bao Lv , Yong-Tang Zheng*, Zheng-Li Shi* and Zhi-Ming Yuan*.Infection with Novel Coronavirus (SARS-CoV-2) Causes Pneumonia in the Rhesus Macaques. Cell Research.（2020）

 

2. Rui Shi, Chao Shan , Xiaomin Duan, Zhihai Chen , Peipei Liu , Jinwen Song ,Tao Song , Xiaoshan Bi, Chao Han, Lianao Wu, Ge Gao, Xue Hu, Yanan Zhang,Zhou Tong, Weijin Huang, William Jun Liu, Guizhen Wu, Bo Zhang, Lan Wang,Jianxun Qi  , Hui Feng 13 , Fu-Sheng Wang*, Qihui Wang* , George Fu Gao*,Zhiming Yuan *& Jinghua Yan*. A Human Neutralizing Antibody Targets the Receptor Binding Site of SARS-CoV-2. Nature.（2020）

3. Liqiang Feng*, Qian Wang*, Chao Shan*, Chenchen Yang, Ying Feng, Jia Wu, Xiaolin Liu, Yiwu Zhou, Rendi Jiang, Peiyu Hu, Xinglong Liu, Fan Zhang, Pingchao Li, XuefengNiu, Yichu Liu, Xuehua Zheng, Jia Luo, Jing Sun, Yingying Gu, Bo Liu, Yongcun Xu, Chufang Li, Weiqi Pan, Jincun Zhao, ChangwenKe, Xinwen Chen, Tao Xu, Nanshan Zhong, Suhua Guan#, Zhiming Yuan#& Ling Chen#. An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques. Nature Communications.（2020）

4. Ze-Jun Wang , Hua-Jun Zhang , Jia Lu , Kang-Wei Xu , Cheng Peng , Jing Guo ,Xiao-Xiao Gao , Xin Wan , Wen-Hui Wang , Chao Shan , Su-Cai Zhang , Jie Wu ,An-Na Yang , Yan Zhu , Ao Xiao , Lei Zhang , Lie Fu , Hao-Rui Si , Qian Cai ,Xing-Lou Yang , Lei You , Yan-Ping Zhou , Jing Liu , De-Qing Pang , Wei-Ping Jin , Xiao-Yu Zhang , Sheng-Li Meng , Yun-Xia Sun , Ulrich Desselberger , Jun-Zhi Wang , Xin-Guo Li , Kai Duan , Chang-Gui Li , Miao Xu , Zheng-Li Shi , Zhi-Ming Yuan , Xiao-Ming Yang & Shuo Shen. Low Toxicity and High Immunogenicity of an Inactivated Vaccine Candidate against COVID-19 in different animal models. Emerging Microbes & Infections.（2020）

5. Xia, Han; Wang, Yujuan; Shi, Chenyan; Atoni, Evans; Zhao, Lu; Yuan, Zhiming(*).Comparative Metagenomic Profiling of Viromes Associated with Four Common Mosquito Species in China.Virol Sin, 2018.2, 33(1): 59~66 ; SCIE

6. Zhao, Lu; Xia, Han; Wang, Yujuan; Evans, Atoni; Zhang, Yunzhi; Yuan, Zhiming(*).Complete Genome Sequence of a New Strain of Tanay Virus, Isolate YN15_103_01, from Yunnan, China.GenomeAnnounc, 2018.2.22, 6(8) ; SCIE

7. Atoni, Evans; Wang, Yujuan; Karungu, Samuel; Waruhiu, Cecilia; Zohaib, Ali; Obanda, Vincent; Agwanda, Bernard; Mutua, Morris; Xia, Han; Yuan, Zhiming(*).MetagenomicVirome Analysis of Culex Mosquitoes from Kenya and China. [J]. Viruses, 2018, 10(1).

8. Xia,Han;Wang,Yujuan;Atoni,Evans;Zhang,Bo; Yuan,Zhiming(*).Mosquito-Associated Viruses in China.Virol Sin, 2018.2, 33(1): 5~20 ; SCIE

9. Hu, Yimin; Cai, Quanxin; Tian, Shen; Ge, Yong; Yuan, Zhiming(*); Hu, Xiaomin(*).Regulator DegU is required for multicellular behavior in Lysinibacillussphaericus.ResMicrobiol, 2018.4, 169(3): 177~187 ; SCIE

10. Geng, Peiling; Hu, Yimin; Zhou, Guoping; Yuan, Zhiming(*); Hu, Xiaomin(*).Characterization of three autolysins with activity against cereulide-producing Bacillus isolates in food matrices

11. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2017.1.16, 241: 291~297 ; SCIE

12. Wang, Yujuan; Xia, Han; Zhang, Bo; Liu, Xiaoyun; Yuan, Zhiming(*).Isolation and characterization of a novel mesonivirus from Culex mosquitoes in China.VIRUS RESEARCH, 2017.8.15, 240: 130~139 ; SCIE

13. Fu, Pan; Ge, Yong; Wu, Yiming; Zhao, Ni; Yuan, Zhiming(*); Hu, Xiaomin(*).The LspC3-41I restriction-modification system is the major determinant for genetic manipulations of Lysinibacillussphaericus C3-41.BMC MICROBIOLOGY, 2017.5.19, 17 ; SCIE

14. Zai, Junjie; Yi, Yinhua; Xia, Han; Zhang, Bo; Yuan, Zhiming(*).A new strategy for full-length Ebola virus glycoprotein expression in E.coli. VIROLOGICA SINICA, 2016.12, 31(6): 500~508 ; SCIE

15. Ge, Sai; Liu, Lei; Xue, Qiang; Yuan, Zhiming(*).Effects of exogenous aerobic bacteria on methane production and biodegradation of municipal solid waste in bioreactors.WASTE MANAGEMENT, 2016.9, 55: 93~98 ; SCIE

16. Li, Xingguang; Zai, Junjie; Liu, Haizhou; Feng, Yi; Li, Fan; Wei, Jing; Zou, Sen; Yuan, Zhiming; Shao, Yiming.The 2014 Ebola virus outbreak in West Africa highlights no evidence of rapid evolution or adaptation to humans. SCIENTIFIC REPORTS, 2016.10.21, 6 ; SCIE

17. Zou J, Xie X, Wang QY, Dong H, Lee MY, Kang C, Yuan Z*, Shi PY, Characterization of dengue virus NS4A and NS4B protein interaction. J Virol. 2015 89(7):3455-70. 

18. Zou J, Lee LT, Wang QY, Xie X, Lu S, Yau YH, Yuan Z, Geifman Shochat S, Kang C, Lescar J, Shi PY. Mapping the interactions between the NS4B and NS3 proteins of dengue virus. J Virol.2015 , 89(7):3471-83. 

19. Shi T, Ge Y, Zhao N, Hu X, Yuan Z*. Polyphosphate kinase of Lysinibacillussphaericus and its effects on accumulation of polyphosphate and bacterial growth. Microbiol Res. 2015, 172:41-7. 

20. Xie X, Zou J, Puttikhunt C, Yuan Z, Shi PY. Two Distinct Sets of NS2A Molecules Are Responsible for Dengue Virus RNA Synthesis and Virion Assembly. See comment in PubMed Commons belowJ Virol. 2015, 89(2):1298-313. 

21. Shi C, Liu Y, Hu X, Xiong J, Zhang B, Yuan Z*，A metagenomic survey of viral abundance and diversity in mosquitoes from Hubei province. PLoS One. 2015,  10(6):e0129845. 

22. Xu Lin-Lin, Chao Shan, Cheng-Lin Deng, Xiao-Dan Li, Bao-Di Shang, Han-Qing Ye, Si-Qing Liu, Zhi-Ming Yuan, Qing-Yin Wang, Pei-Yong Shi, Bo Zhang: Development of a stable Gaussia luciferase enterovirus 71 reporter virus. J Virol Methods,2015, 219:62-6. 

23. Li XD, Ye HQ, Deng CL, Liu SQ, Zhang HL, Shang BD, Shi PY, Yuan ZM, Zhang B,  Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus. J Gen Virol. 2015, 96(Pt 6):1264-75. 

24. Liu SQ, Deng CL, Yuan ZM, Rayner S, Zhang B, Identifying the pattern of molecular evolution for Zaire ebolavirus in the 2014 outbreak in West Africa. Infect Genet Evol. 2015, 32:51-9. 

25. Ge Y, Hu X, Zhao N, Shi T, Cai Q, Yuan Z*, A new tubRZ operon involved in the maintenance of the Bacillus sphaericusmosquitocidal plasmid pBsph. Microbiology. 2014, 160(Pt 6):1112-24 Apr 11.

26. Ge Y, Zhao N, Hu X, Shi T, Cai Q, Yuan Z*，J Bacteriol.A novel transcriptional activator tubX is required for the stability of Bacillus sphaericusmosquitocidal plasmid pBsph. J. Bacteriol. 01855-14. 2014 Sep 29.

27. Liu Y, Liu H, Zou J, Zhang B,Yuan Z*，Dengue virus subgenomic RNA induces apoptosis through the Bcl-2-mediated PI3k/Akt signaling pathway，Virology. 2014, 448:15-25.

28. Zhao N, Ge Y, Shi T, Hu X, Yuan Z*. A collagen-like glycoprotein BclS is involved in the formation of filamentous structures of the exosporium of Lysinibacillussphaericus. Appl Environ Microbiol. 2014,80(21):6656-63.

29. Guo QY, Cai QX, Yan JP, Hu XM, Zheng DS, Yuan ZM*，Single nucleotide deletion of cqm1 gene results in the development of resistance to Bacillus sphaericus in Culexquinquefasciatus. J Insect Physiol. 2013,59(9): 967-973

30. Fan Jingjing, Yi Liu, XupingXie, Bo Zhang and Zhiming Yuan*, Inhibition of Japanese Encephalitis Virus Infection by Flavivirus Recombinant E Protein Domain III，Virologica Sinica, 2013, 28 (3):152-160

31. Li J, Yang L, Hu X, Zheng D, Yan J, Yuan Z*，Nanoscale mono- and multi-layer cylinder structures formed by recombinant S-layer proteins of mosquitocidal Bacillus sphaericus C3-41，Appl Microbiol Biotechnol.2013, 97(16): 7275-83 (IF: 3.689)