Yanyi WANG
Title: Principal Investigator E-mail: wangyy@wh.iov.cn
Education
Publications
1. Li WW, Nie Y, Yang Y, Ran Y, Luo WW, Xiong MG, Wang SY, Xu ZS*, Wang YY*. Ubiquitination of TLR3 by TRIM3 signals its ESCRT mediated trafficking to the endolysosomes for innate antiviral response. PNAS, 2020, 117(38), 23707-23716.
2. Fu YZ#*, Wang SY#,Zheng ZQ#,Huang Y, Li WW,Xu ZS,Wang YY*. SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response. Cellular & Molecular Immunology.DOI: 10.1038/s41423-020-00571-x.
3. Wang DP,Zhang HY,Liao BW, Tong Z, Xu ZS,Wang YY*,Yang Y*. SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5. Virologica Sinica. DOI: 10.1007/s12250-020-00267-6.
4. Xu ZS#, Shu T #, Kang L #, Wu D#, Zhou X #, Liao BW , Sun XL, Zhou X, Wang YY*.Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients. Signal Transduction and Targeted Therapy,2020,5(1):100.DOI: 10.1038/s41392-020-0211-1.
5. Zou HM, Huang ZF, Yang Y, Luo WW, Wang SY , Luo MH, Fu YZ *,Wang YY*. Human Cytomegalovirus Protein UL94 Targets MITA to Evade Antiviral Immune Response. Journal of Virology, 2020 Apr 1. pii: JVI.00022-20. doi: 10.1128/JVI.00022-20.
6. Xiong MG, Xu ZS, Luo WW, Li YH,Wang SY ,Wang YY*, Ran Y*.RNF152 positively regulatesTLR/IL-1R signaling by enhancing signaling MyD88 oligomerizationo.EMBO Reports，(2020) 21: e48860.
7. Zhang HY, Liao BW, Xu ZS, Ran Y, Wang DP, Yang Y, Luo WW* and Wang YY*.USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA.PLoS Pathogens, 2019，16(1):e1008178.
8. Ran Y*, Xiong MG, Xu ZS, Luo WW, Wang SY and Wang YY.YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking. Journal of Immunology ,2019,203(6)1560-1570.
9. Fu YZ,Guo Y,Zou HM,Su S,Wang SY,Yang Q, Luo MH, Wang YY*. Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response. PLoS Pathogens, 2019；15(5):e1007691.
10. Xu ZS#,Zhang HX#,Li WW,Ran Y,Liu TT,Xiong MG,Li QL,Wang SY, Wu M,Shu HB,Xia HM, Wang YY*.FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis. PNAS, 2019.116(21):10447-10452.
11. Fu YZ,Su S,Zou HM,Guo Y,Wang SY,Li S,Luo MH, Wang YY*.Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3- and NF-kB-Mediated Transcription.Journal of Virology,June 2019 93(11):e00181-19.
12. Zhang HX#,Xu ZS#, Lin H,Li M, Xia T, Cui KS; WangSY,Li YJ, Shu HB*, Wang YY*.TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis.Nature Communications, 2018,9:3441.
13. Huang ZF, Zou HM, Liao BW, Zhang HY, Yang Y, Fu YZ, Wang SY, Luo MH, Wang YY*.Human Cytomegalovirus Protein UL31 Inhiibits DNA Sensing of cGAS to Mediate Immune Evasion.Cell Host&Microbe, 2018 Jul 11;24(1):69-80.e4. doi: 10.1016/j.chom.2018.05.007. Epub 2018 Jun 21.
14. Xiong MG, Wang SY, Wang YY, Ran Y*. The Regulation of cGAS.Virologica Sinica,(2018)33:117-124.
15. Luo WW, Li S, Li C, Zheng ZQ,Cao P,Tong Z, Lian H, Wang SY, Shu HB, Wang Y Y*. IRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA. PLoS Pathogenes2017; 13(11): e1006693.
16. Nie Y, Ran Y, Zhang HY, Huang ZF, Pan ZY, Wang SY, Wang YY*.GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.PLoS Pathogens, 2017 Apr; 13(4): e1006328.
17. Yang Y, Wang SY, Huang ZF, Zou HM, Yan BR, Luo WW, Wang YY*. The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response. Cell Reserch, 2016,26(3):288-303.
18. Ran Y, Zhang J, Liu L L, Pan ZY, Nie Y, Zhang HY, Wang YY*. Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response. Journal of Molecular Cell Biology, 2016, 8(1), 31–43. Epub 2015 Nov 26.
