Express | Research Articles on COVID-19 Published by WIV Scientists----Wuhan Institute of Virology

Express | Research Articles on COVID-19 Published by WIV Scientists

Date：19-04-2020 | 【Print】【close】

A Nanoparticle Vaccine Displaying Conserved Epitopes of the Preexisting Neutralizing Antibody Confers Broad Protection against SARS-CoV-2 Variants

Wu X, Li W, Rong H, Pan J, Zhang X, Hu Q, Shi ZL, Zhang XE, Cui Z.

ACS Nano.

Published: 27 June 2024

DOI: https://doi.org/10.1021/acsnano.4c03075

Developing nucleoside tailoring strategies against SARS-CoV-2 via ribonuclease targeting chimera

Min Y, Xiong W, Shen W, Liu X, Qi Q, Zhang Y, Fan R, Fu F, Xue H, Yang H, Sun X, Ning Y, Tian T, Zhou X.

Sci Adv.

Published: 12 April 2024

DOI: https://doi.org/10.1126/sciadv.adl4393

Emergence of SARS and COVID-19 and preparedness for the next emerging disease X

Hu B, Guo H, Si H, Shi Z.

Front Med.

Published: 2 April 2024

DOI: https://doi.org/10.1007/s11684-024-1066-6

Effectiveness of a broad-spectrum bivalent mRNA vaccine against SARS-CoV-2 variants in preclinical studies

Lu J, Tan S, Gu H, Liu K, Huang W, Yu Z, Lu G, Wu Z, Gao X, Zhao J, Yao Z, Yi F, Yang Y, Wang H, Hu X, Lu M, Li W, Zhou H, Yu H, Shan C, Lin J.

Emerg Microbes Infect.

Published: 20 February 2024

DOI: https://doi.org/10.1080/22221751.2024.2321994

SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis

Zhao H, Cai Z, Rao J, Wu D, Ji L, Ye R, Wang D, Chen J, Cao C, Hu N, Shu T, Zhu P, Wang J, Zhou X, Xue Y.

Mol Cell.

Published: 1 February 2024

DOI: https://doi.org/10.1016/j.molcel.2023.11.032

Deep spatial proteomics reveals region-specific features of severe COVID-19-related pulmonary injury

Mao Y, Chen Y, Li Y, Ma L, Wang X, Wang Q, He A, Liu X, Dong T, Gao W, Xu Y, Liu L, Ren L, Liu Q, Zhou P, Hu B, Zhou Y, Tian R, Shi ZL.

Cell Rep.

Published: 18 January 2024

DOI: https://doi.org/10.1016/j.celrep.2024.113689

Long-term immune response to Omicron-specific mRNA vaccination in mice, hamsters, and nonhuman primates

Wu Y, Wu N, Jia X, Wu Y, Zhang X, Liu Y, Hou Y, Shen Y, Li E, Wang W, Wang Y, Chiu S.

MedComm (2020)

Published: 15 December 2023

DOI: https://doi.org/10.1002/mco2.460

Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry

Wang H, Yang Q, Liu X, Xu Z, Shao M, Li D, Duan Y, Tang J, Yu X, Zhang Y, Hao A, Wang Y, Chen J, Zhu C, Guddat L, Chen H, Zhang L, Chen X, Jiang B, Sun L, Rao Z, Yang H.

Nat Commun.

Published: 21 November 2023

DOI: https://doi.org/10.1038/s41467-023-42527-5

Newcastle Disease Virus (NDV)-based vaccine candidate against SARS-CoV-2 Omicron by intranasal immunization

Zhang QY, Zhang HQ, Zhang YN, Zhang ZR, Li XD, Hao MC, Zhang Y, Li JQ, Hu YY, Chen XL, Wang J, Shi YJ, Deng CL, Chen JJ, Ye HQ, Zhang B.

Antiviral Res.

Published: 19 November 2023

DOI: https://doi.org/10.1016/j.antiviral.2023.105757

Prevalence of respiratory viruses among hospitalized children with lower respiratory tract infections during the COVID-19 pandemic in Wuhan, China

Li Y, Wu Z, Yan Y, Shi Y, Huang J, Du H, Du Q, Li Y, Lin Y, Liu D, Lu X.

Int J Infect Dis.

Published: 18 November 2023

DOI: https://doi.org/10.1016/j.ijid.2023.11.019

Chrysin 7-O-β-D-glucuronide, a dual inhibitor of SARS-CoV-2 3CLpro and PLpro, for the prevention and treatment of COVID-19

Yi Y, Yu R, Xue H, Jin Z, Zhang M, Bao YO, Wang Z, Wei H, Qiao X, Yang H.

Int J Antimicrob Agents.

Published: 17 November 2023

DOI: https://doi.org/10.1016/j.ijantimicag.2023.107039

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

Tan S, Zhao J, Hu X, Li Y, Wu Z, Lu G, Yu Z, Du B, Liu Y, Li L, Chen Y, Li Y, Yao Y, Zhang X, Rao J, Gao G, Peng Y, Liu H, Yuan Z, Liu J, Wang Q, Hu H, Gao X, Zhou H, Yu H, Xu Y, Yu W, Feng L, Wang M, Shan C, Lu J, Lin J.

Sci Bull (Beijing).

Published: 14 November 2023

DOI: https://doi.org/10.1016/j.scib.2023.11.024

Protection of the receptor binding domain (RBD) dimer against SARS-CoV-2 and its variants

Wu Y, Shi J, He X, Lu J, Gao X, Zhu X, Chen X, Zhang M, Fang L, Zhang J, Yuan Z, Xiao G, Zhou P, Pan X.

J Virol.

Published: 16 October 2023

DOI: https://doi.org/10.1128/jvi.01279-23

Single particle tracking reveals SARS-CoV-2 regulating and utilizing dynamic filopodia for viral invasion

Zhang Y, Zhang X, Li Z, Zhao W, Yang H, Zhao S, Tang D, Zhang Q, Li Z, Liu H, Li H, Li B, Lappalainen P, Xu T, Cui Z, Jiu Y.

Sci Bull (Beijing).

Published: 15 October 2023

DOI: https://doi.org/10.1016/j.scib.2023.08.031

Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir

Jiang X, Su H, Shang W, Zhou F, Zhang Y, Zhao W, Zhang Q, Xie H, Jiang L, Nie T, Yang F, Xiong M, Huang X, Li M, Chen P, Peng S, Xiao G, Jiang H, Tang R, Zhang L, Shen J, Xu Y.

Nat Commun.

Published: 13 October 2023

DOI: https://doi.org/10.1038/s41467-023-42102-y

Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge

Liu Q, Zhao H, Li Z, Zhang Z, Huang R, Gu M, Zhuang K, Xiong Q, Chen X, Yu W, Qian S, Zhang Y, Tan X, Zhang M, Yu F, Guo M, Huang Z, Wang X, Xiang W, Wu B, Mei F, Cai K, Zhou L, Zhou L, Wu Y, Yan H, Cao S, Lan K, Chen Y.

Signal Transduct Target Ther.

Published: 14 September 2023

DOI: https://doi.org/10.1038/s41392-023-01615-0

Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group

Ren P, Li H, Nie T, Jian X, Yu C, Li J, Su H, Zhang X, Li S, Yang X, Peng C, Yin Y, Zhang L, Xu Y, Liu H, Bai F.

J Med Chem.

Published: 18 August 2023

DOI: https://doi.org/10.1021/acs.jmedchem.3c00818

A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery

Wu L, Zheng A, Tang Y, Chai Y, Chen J, Cheng L, Hu Y, Qu J, Lei W, Liu WJ, Wu G, Zeng S, Yang H, Wang Q, Gao GF.

Sci China Life Sci.

Published: 11 August 2023

DOI: https://doi.org/10.1007/s11427-023-2410-5

Impact of SARS-CoV-2 envelope protein mutations on the pathogenicity of Omicron XBB

Wang Y, Pan X, Ji H, Zuo X, Xiao GF, Li J, Zhang LK, Xia B, Gao Z.

Cell Discov.

Published: 28 July 2023

DOI: https://doi.org/10.1038/s41421-023-00575-7

A new cellular interactome of SARS-CoV-2 nucleocapsid protein and its biological implications

Min YQ, Huang M, Feng K, Jia Y, Sun X, Ning YJ.

Mol Cell Proteomics.

Published: 19 May 2023

DOI: https://doi.org/10.1016/j.mcpro.2023.100579

SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria

Zong S, Wu Y, Li W, You Q, Peng Q, Wang C, Wan P, Bai T, Ma Y, Sun B, Qiao J.

Virol Sin.

Published: 6 May 2023

DOI: https://doi.org/10.1016/j.virs.2023.05.003

Synthesis, cytotoxicity, and pharmacokinetic evaluations of niclosamide analogs for anti-SARS-CoV-2

Li R, Zhang Z, Huang S, Peng K, Jiang H, Shen J, Zhang B, Jiang X.

Eur J Med Chem.

Published: 5 May 2023

DOI: https://doi.org/10.1016/j.ejmech.2023

Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19

Xu H, Li S, Liu J, Cheng J, Kang L, Li W, Zhong Y, Wei C, Fu L, Qi J, Zhang Y, You M, Zhou Z, Zhang C, Su H, Yao S, Zhou Z, Shi Y, Deng R, Lv Q, Li F, Qi F, Chen J, Zhang S, Ma X, Xu Z, Li S, Xu Y, Peng K, Shi Y, Jiang H, Gao GF, Huang L.

Proc Natl Acad Sci U S A.

Published: 2 May 2023

DOI: https://doi.org/10.1073/pnas.2301775120

Rapid and Accurate Detection of SARS-CoV-2 Using an iPad-Controlled, High-Throughput, Portable, and Multiplex Hive-Chip Platform (HiCube)

Zhu Y, Odiwuor N, Sha Z, Chen Y, Shao N, Wu X, Chen J, Li Y, Guo S, Shi D, Liu P, Zhang Y, Wei H, Tao SC.

ACS Sens.

Published: 24 April 2023

DOI: https://doi.org/10.1021/acssensors.3c00031

Oridonin inhibits SARS-CoV-2 replication by targeting viral proteinase and polymerase

Zhang Z, Zhang H, Zhang Y, Zhang Q, Liu Q, Hu Y, Chen X, Wang J, Shi Y, Deng C, Gong P, Zhang B, Li X, Zhu B, Ye H.

Virol Sin.

Published: 29 April 2023

DOI: https://doi.org/10.1016/j.virs.2023.04.008

Evolution of Immune Evasion and Host Range Expansion by the SARS-CoV-2 B.1.1.529 (Omicron) Variant

Ren W, Zhang Y, Rao J, Wang Z, Lan J, Liu K, Zhang X, Hu X, Yang C, Zhong G, Zhang R, Wang X, Shan C, Ding Q.

mBio.

Published: 3 April 2023

DOI: https://doi.org/10.1128/mbio.00416-23

Advances in developing ACE2 derivatives against SARS-CoV-2

Zhang H, Lv P, Jiang J, Liu Y, Yan R, Shu S, Hu B, Xiao H, Cai K, Yuan S, Li Y.

Lancet Microbe.

Published: 16 March 2023

DOI: https://doi.org/10.1016/S2666-5247(23)00011-3

A novel mAb broadly neutralizes SARS-CoV-2 VOCs in vitro and in vivo, including the Omicron variants

Kan Q, Lin X, Li T, Ke X, Jian X, Zou Z, Zhang W, Wan Z, Xie Q, Shao H, Ye L, Ye J, Qin A, Hou L, Chen Q.

J Med Virol.

Published: 13 March 2023

DOI: https://doi.org/10.1002/jmv.28657

High-Intensity Ultraviolet-C Irradiation Efficiently Inactivates SARS-CoV-2 Under Typical Cold Chain Temperature

Li P, Ke X, Leng D, Lin X, Yang W, Zhang H, Tian C, Xu H, Chen Q.

Food Environ Virol.

Published: 8 March 2023

DOI: https://doi.org/10.1007/s12560-023-09552-5

Novel Tetrahydroisoquinoline-Based Heterocyclic Compounds Efficiently Inhibit SARS-CoV-2 Infection In Vitro

Wang X, Burdzhiev NT, Hu H, Li Y, Li J, Lozanova VV, Kandinska MI, Wang M.

Viruses.

Published: 11 Feburary 2023

DOI: https://doi.org/10.3390/v15020502

Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination among COVID-19 convalescents

Wang H, Yuan Y, Wu B, Xiao M, Wang Z, Diao T, Zeng R, Chen L, Lei Y, Long P, Guo Y, Lai X, Wen Y, Li W, Cai H, Song L, Ni W, Zhao Y, Ouyang K, Wang J, Wang Q, Liu L, Wang C, Pan A, Li X, Gong R, Wu T.

Front Med.

Published: 4 Feburary 2023

DOI: https://doi.org/10.1007/s11684-022-0954-x

Liu MQ, Lin HF, Li J, Chen Y, Luo Y, Zhang W, Hu B, Tian FJ, Hu YJ, Liu YJ, Jiang RD, Gong QC, Li A, Guo ZS, Li B, Yang XL, Tong YG, Shi ZL.

J Virol.

Published: 23 January 2023

DOI: https://doi.org/10.1128/jvi.01719-22

Antiviral effects and tissue exposure of tetrandrine against SARS-CoV-2 infection and COVID-19

Liu J, Wang F, Wang X, Fan S, Li Y, Xu M, Hu H, Liu K, Zheng B, Wang L, Zhang H, Li J, Li W, Zhang W, Hu Z, Cao R, Zhuang X, Wang M, Zhong W.

MedComm (2020).

Published: 19 January 2023

DOI: https://doi.org/10.1002/mco2.206

Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2

Ren P, Yu C, Zhang R, Nie T, Hu Q, Li H, Zhang X, Zhang X, Li S, Liu L, Dai W, Li J, Xu Y, Su H, Zhang L, Liu H, Bai F.

Eur J Med Chem.

Published: 18 January 2023

DOI: https://doi.org/10.1016/j.ejmech

SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses

Li S, Zhang Y, Guan Z, Ye M, Li H, You M, Zhou Z, Zhang C, Zhang F, Lu B, Zhou P, Peng K.

Cell Res.

Published: 17 January 2023

DOI: https://doi.org/10.1038/s41422-022-00775-y

Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2

Xia B, Pan X, Luo RH, Shen X, Li S, Wang Y, Zuo X, Wu Y, Guo Y, Xiao G, Li Q, Long XY, He XY, Zheng HY, Lu Y, Pang W, Zheng YT, Li J, Zhang LK, Gao Z.

Cell Discov.

Published: 6 January 2023

DOI: https://doi.org/10.1038/s41421-022-00510-2

Hybridoma-derived neutralizing monoclonal antibodies against Beta and Delta variants of SARS-CoV-2 in vivo

Wang Q, Peng L, Nie Y, Shu Y, Zhang H, Song Z, Li Y, Hu H, Li L, Wang X, Liu J, Li J, Shi Z, Deng F, Guo Y, Zhou Y, Yan B, Hu Z, Wang M.

Virol Sin.

Published: 31 December 2022

DOI: https://doi.org/10.1016/j.virs.2022.12.007

CRISPR/Cas13a Trans-Cleavage-Triggered Catalytic Hairpin Assembly Assay for Specific and Ultrasensitive SARS-CoV-2 RNA Detection

Yang Y, Yi W, Gong F, Tan Z, Yang Y, Shan X, Xie C, Ji X, Zheng Z, He Z.

Anal Chem.

Published: 26 December 2022

DOI: https://doi.org/10.1021/acs.analchem.2c04306

Synthesis of maleimide-braced peptide macrocycles and their potential anti-SARS-CoV-2 mechanisms

Li J, Sun J, Zhang X, Zhang R, Wang Q, Wang L, Zhang L, Xie X, Li C, Zhou Y, Wang J, Xiao G, Bai F, Liu H.

Chem Commun (Camb).

Published: 22 December 2022

DOI: https://doi.org/10.1039/d2cc06371a

An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant

Zhang HQ, Zhang YN, Zhang ZR, Chen XL, Hu YY, Shi YJ, Wang J, Deng CL, Zhang B, Li XD, Ye HQ.

Signal Transduct Target Ther.

Published: 14 December 2022

DOI: https://doi.org/10.1038/s41392-022-01246-x.

A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration

Ma H, Zhang X, Zeng W, Zhou J, Chi X, Chen S, Zheng P, Wang M, Wu Y, Zhao D, Gong F, Lin H, Sun H, Yu C, Shi Z, Hu X, Zhang H, Jin T, Chiu S.

Cell Discov.

Published: 9 December 2022

DOI: https://doi.org/10.1038/s41421-022-00497-w.

SARS-CoV-2 infection activates CREB/CBP in cellular cyclic AMP-dependent pathways

Yang Q, Tang J, Cao J, Liu F, Fu M, Xue B, Zhou A, Chen S, Liu J, Zhou Y, Shi Y, Peng W, Chen X.

J Med Virol.

Published: 8 December 2022

DOI: https://doi.org/10.1002/jmv.28383

Humoral and cellular immunity of two-dose inactivated COVID-19 vaccination in Chinese children: a prospective cohort study

Wang H, Gan M, Wu B, Zeng R, Wang Z, Xu J, Li J, Zhang Y, Cao J, Chen L, Di D, Peng S, Lei J, Zhao Y, Song X, Yuan T, Zhou T, Liu Q, Yi J, Wang X, Cai H, Lei Y, Wen Y, Li W, Chen Q, Wang Y, Long P, Yuan Y, Wang C, Pan A, Wang Q, Gong R, Fan X, Wu T, Liu L.

J Med Virol.

Published: 7 December 2022

DOI: https://doi.org/10.1002/jmv.28380

Sertraline Is an Effective SARS-CoV-2 Entry Inhibitor Targeting the Spike Protein

Chen Y, Wu Y, Chen S, Zhan Q, Wu D, Yang C, He X, Qiu M, Zhang N, Li Z, Guo Y, Wen M, Lu L, Ma C, Guo J, Xu W, Li X, Li L, Jiang S, Pan X, Liu S, Tan S.

J Virol.

Published: 5 December 2022

DOI: https://doi.org/10.1128/jvi.01245-22

A luciferase based automated assay for rapid and sensitive detection of SARS-CoV-2 antibodies

Zhou W, He P, Liu H, Wei H, Yu J.

Anal Chim Acta.

Published: 16 November 2022

DOI: https://doi.org/10.1016/j.aca.2022.340633

A potent, broadly protective vaccine against SARS-CoV-2 variants of concern

Wang Z, An J, Liu K, Yu P, Fang X, Li J, Zhu H, Zhu Q, Huang C, Zhang C, Zhao B, Bao L, Song Y, Cao X, Hu D, Jiang Y, Shi L, Zhou L, Fan J, Guan W, Zhou C, Hu Z, Yuan Z, Liu J, Shan C, Liu G.

NPJ Vaccines.

Published: 12 November 2022

DOI: https://doi.org/10.1038/s41541-022-00571-0

Identification of phytochemicals in Qingfei Paidu decoction for the treatment of coronavirus disease 2019 by targeting the virus-host interactome

Li Y, Wu Y, Li S, Li Y, Zhang X, Shou Z, Gu S, Zhou C, Xu D, Zhao K, Tan S, Qiu J, Pan X, Li L.

Biomed Pharmacother

Published: 31 October 2022

DOI: https://doi.org/10.1016/j.biopha.2022.113946

In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2

Shang W, Dai W, Yao C, Xu L, Tao X, Su H, Li J, Xie X, Xu Y, Hu M, Xie D, Jiang H, Zhang L, Liu H.

Antiviral Res.

Published: 29 October 2022

DOI: https://doi.org/10.1016/j.antiviral.2022.105450

A triple-RBD-based mucosal vaccine provides broad protection against SARS-CoV-2 variants of concern

Yang J, Liu MQ, Liu L, Li X, Xu M, Lin H, Liu S, Hu Y, Li B, Liu B, Li M, Sun Y, Chen YQ, Shi ZL, Yan H.

Cell Mol Immunol.

Published: 11 October 2022

DOI: https://doi.org/10.1038/s41423-022-00929-3

SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope

He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X.

Nat Microbiol.

Published: 23 September 2022

DOI: https://doi.org/10.1038/s41564-022-01235-4

A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery

Zhang X, Zhang H, Li T, Chen S, Luo F, Zhou J, Zheng P, Song S, Wu Y, Jin T, Tang N, Jin A, Yang C, Cheng G, Gong R, Chiu S, Huang A.

Signal Transduct Target Ther.

Published: 30 August 2022

DOI: https://doi.org/10.1038/s41392-022-01135-3

Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients

Yang Z, Wu D, Lu S, Qiu Y, Hua Z, Tan F, Zhang C, Zhang L, Zhang DY, Zhou X, Cai Z, Shang Y, Lin SH.

Proc Natl Acad Sci U S A.

Published: 9 August 2022

DOI: https://doi.org/10.1073/pnas.2117089119

Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron

Ma H, Zhang X, Zheng P, Dube PH, Zeng W, Chen S, Cheng Q, Yang Y, Wu Y, Zhou J, Hu X, Xiang Y, Zhang H, Chiu S, Jin T.

Cell Res.

Published: 29 July 2022

DOI: https://doi.org/10.1038/s41422-022-00700-3

Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376

Luan XD, Chen BX, Shang WJ, Yin WC, Jin Y, Zhang LK, Xu HE, Zhang SY.

Acta Pharmacol Sin.

Published: 30 June 2022

DOI: https://doi.org/10.1038/s41401-022-00929-z

Bergamottin, a bioactive component of bergamot, inhibits SARS-CoV-2 infection in golden Syrian hamsters

Minmin Zhou, Yang Liu, Junyuan Cao, Siqi Dong, Yuxia Hou, Yan Yu, Qiuyan Zhang, Yueli Zhang, Xiaoying Jia, Bo Zhang, Gengfu Xiao, Gang Li, Wei Wang

Antiviral Research

Published: 19 June 2022

DOI: https://doi.org/10.1016/j.antiviral.2022.105365

Efficacy of heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial

Wang XY, Mahmood SF, Jin F, Cheah WK, Ahmad M, Sohail MA, Ahmad W, Suppan VK, Sayeed MA, Luxmi S, Teo AH, Lee LY, Qi YY, Pei RJ, Deng W, Xu ZH, Yang JM, Zhang Y, Guan WX, Yu X.

Emerg Microbes Infect.

Published: 10 June 2022

DOI: https://doi.org/10.1080/22221751.2022.2088406

mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern

Wang H, Chen Z, Wang Z, Li J, Yan Z, Yuan J, Zhu A, Chen L, Liu Y, Hu C, Zhu A, Li G, Li Y, Deng J, Ma L, Sui X, Miao W, Li J, Zheng X, Piao J, Yao Y, Rao J, Shan C, Yuan Z, Zhao J, Zhu T.

Emerg Microbes Infect.

Published: 23 May 2022

DOI: https://doi.org/10.1080/22221751.2022.2081616

The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate

Wang H, Pei R, Li X, Deng W, Xing S, Zhang Y, Zhang C, He S, Sun H, Xiao S, Xiong J, Zhang Y, Chen X, Wang Y, Guo Y, Zhang B, Shang L.

Eur J Med Chem.

Published: 13 May 2022

DOI: https://doi.org/10.1016/j.ejmech.2022.114458

Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses

Wang Y, Liu M, Shen Y, Ma Y, Li X, Zhang Y, Liu M, Yang XL, Chen J, Yan R, Luan D, Wang Y, Chen Y, Wang Q, Lin H, Li Y, Wu K, Zhu T, Zhao J, Lu H, Wen Y, Jiang S, Wu F, Zhou Q, Shi ZL, Huang J.

Cell Discov.

Published: 21 April 2022

DOI: https://doi.org/10.1038/s41421-022-00401-6

Single-Cell Landscape of Lungs Reveals Key Role of Neutrophil-Mediated Immunopathology during Lethal SARS-CoV-2 Infection

Zheng XS, Wang Q, Min J, Shen XR, Li Q, Zhao QC, Wang X, Jiang RD, Geng R, Chen Y, Zhu Y, Li B, Zhang W, Li A, Xie TT, Liu MQ, Cheng L, Shi ZL, Zhou P.

J Virol.

Published: 14 April 2022

DOI: https://doi.org/10.1128/jvi.00038-22

Potent Anti-SARS-CoV-2 Efficacy of COVID-19 Hyperimmune Globulin from Vaccine-Immunized Plasma

Yu D, Li YF, Liang H, Wu JZ, Hu Y, Peng Y, Li TJ, Hou JF, Huang WJ, Guan LD, Han R, Xing YT, Zhang Y, Liu J, Feng L, Li CY, Liang XL, Ding YL, Zhou ZJ, Ji DM, Wang FF, Yu JH, Deng K, Xia DM, Dong DM, Hu HR, Liu YJ, Fu DX, He YL, Zhou DB, Yang HC, Jia R, Ke CW, Du T, Xie Y, Zhou R, Li CS, Wang ML, Yang XM.

Adv Sci (Weinh).

Published: 11 April 2022

DOI: https://doi.org/10.1002/advs.202104333

A 1-year longitudinal study on COVID-19 convalescents reveals persistence of anti-SARS-CoV-2 humoral and cellular immunity

Li Y, Wang X, Shen XR, Geng R, Xie N, Han JF, Zhang QM, Shi ZL, Zhou P.

Emerg Microbes Infect.

Published: 30 March 2022

DOI: https://doi.org/10.1080/22221751.2022.2049984

Inactivated SARS-CoV-2 Vaccine Shows Cross-Protection against Bat SARS-Related Coronaviruses in Human ACE2 Transgenic Mice

Liu MQ, Jiang RD, Guo J, Chen Y, Yang DS, Wang X, Lin HF, Li A, Li B, Hu B, Wang ZJ, Yang XL, Shi ZL.

J Virol.

Published: 28 March 2022

DOI: https://doi.org/10.1128/jvi.00169-22

Long-Term Preservation of SARS-CoV-2 RNA in Silk for Downstream RT-PCR Tests

Nyaruaba R, Hong W, Li X, Yang H, Wei H.

Anal Chem.

Published: 15 March 2022

DOI: https://doi.org/10.1021/acs.analchem.2c00169

ACE2-independent infection of T lymphocytes by SARS-CoV-2

Shen XR, Geng R, Li Q, Chen Y, Li SF, Wang Q, Min J, Yang Y, Li B, Jiang RD, Wang X, Zheng XS, Zhu Y, Jia JK, Yang XL, Liu MQ, Gong QC, Zhang YL, Guan ZQ, Li HL, Zheng ZH, Shi ZL, Zhang HL, Peng K, Zhou P.

Signal Transduct Target Ther.

Published: 11 March 2022

DOI: https://doi.org/10.1038/s41392-022-00919-x

Digital PCR Applications in the SARS-CoV-2/COVID-19 Era: a Roadmap for Future Outbreaks

Nyaruaba R, Mwaliko C, Dobnik D, Neuzil P, Amoth P, Mwau M, Yu J, Yang H, Wei H.

Clin Microbiol Rev.

Published: 8 March 2022

DOI: https://doi.org/10.1128/cmr.00168-21

A protein vaccine with Alum/c-GAMP/poly(I:C) rapidly boosts robust immunity against SARS-CoV-2 and variants of concern

Zhang RY, Yin XG, Zhou SH, Zhang HW, Lu J, He CB, Wang J, Wen Y, Li YT, Liu YL, Feng RR, Ding D, Wei HW, Gong R, Yang GF, Guo J.

Chem Commun (Camb)

Published: 4 March 2022

DOI: https://doi.org/10.1039/d2cc00271j

Covalently Engineered Protein Minibinders with Enhanced Neutralization Efficacy against Escaping SARS-CoV-2 Variants

Han Y, Yang Z, Hu H, Zhang H, Chen L, Li K, Kong L, Wang Q, Liu B, Wang M, Lin J, Chen PR.

J Am Chem Soc.

Published: 25 February 2022

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Different pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters

Zhang YN, Zhang ZR, Zhang HQ, Li N, Zhang QY, Li XD, Deng CL, Deng F, Shen S, Zhu B, Zhang B.

Signal Transduct Target Ther.

Published: 25 February 2022

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Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

Dai W, Jochmans D, Xie H, Yang H, Li J, Su H, Chang D, Wang J, Peng J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L, Xu Y, Neyts J, Liu H.

J Med Chem.

Published: 24 February 2022

DOI: https://doi.org/10.1021/acs.jmedchem.0c02258

A point-of-care SARS-CoV-2 test based on reverse transcription loop-mediated isothermal amplification without RNA extraction with diagnostic performance same as RT-PCR

Odiwuor N, Xiong J, Ogolla F, Hong W, Li X, Khan FM, Wang N, Yu J, Wei H.

Anal Chim Acta.

Published: 15 February 2022

DOI: https://doi.org/10.1016/j.aca.2022.339590

ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variants

Ou J, Zhang Y, Wang Y, Zhang Z, Wei H, Yu J, Wang Q, Wang G, Zhang B, Wang C.

Signal Transduct Target Ther.

Published: 9 February 2022

DOI: https://doi.org/10.1038/s41392-022-00913-3

Screening of Botanical Drugs against SARS-CoV-2 Entry Reveals Novel Therapeutic Agents to Treat COVID-19

Junyuan Cao,Yang Liu,Minmin Zhou, Siqi Dong, Yuxia Hou, Xiaoying Jia, Xiaohao Lan, Yueli Zhang, Jiao Guo, Gengfu Xiao, Wei Wang

Viruses

Published: 8 February 2022

DOI: https://doi.org/10.3390/v14020353

A new screening system for entry inhibitors based on cell-to-cell transmitted syncytia formation mediated by self-propagating hybrid VEEV-SARS-CoV-2 replicon

Li N, Chen XL, Li Q, Zhang ZR, Deng CL, Zhang B, Li XD, Ye HQ.

Emerg Microbes Infect.

Published: 4 February 2022

DOI: https://doi.org/10.1080/22221751.2022.2030198

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Long Y, Sun J, Song TZ, Liu T, Tang F, Zhang X, Ding L, Miao Y, Zhu W, Pan X, An Q, Qin M, Tong X, Peng X, Yu P, Zhu P, Xu J, Zhang X, Zhang Y, Liu D, Chen B, Chen H, Zhang L, Xiao G, Zuo J, Tang W, Zhou J, Li H, Xu Z, Zheng HY, Long XY, Qin Q, Gan Y, Ren J, Huang W, Zheng YT, Jin G, Gong L.

Cell Discov.

Published: 1 February 2022

DOI: https://doi.org/10.1038/s41421-021-00370-2

Target-Based Virtual Screening and LC/MS-Guided Isolation Procedure for Identifying Phloroglucinol-Terpenoid Inhibitors of SARS-CoV-2

Hou B, Zhang YM, Liao HY, Fu LF, Li DD, Zhao X, Qi JX, Yang W, Xiao GF, Yang L, Zuo ZY, Wang L, Zhang XL, Bai F, Yang L, Gao GF, Song H, Hu JM, Shang WJ, Zhou J.

J Nat Prod.

Published: 27 January 2022

DOI: https://doi.org/10.1021/acs.jnatprod.1c00805

Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan, China

Liu Q, Xiong Q, Mei F, Ma C, Zhang Z, Hu B, Xu J, Jiang Y, Zhan F, Zhou S, Tao L, Chen X, Guo M, Wang X, Fang Y, Shen S, Liu Y, Liu F, Zhou L, Xu K, Ke C, Deng F, Cai K, Yan H, Chen Y, Lan K.

Innovation (N Y).

Published: 25 January 2022

DOI: https://doi.org/10.1016/j.xinn.2021.100181

Self-Adjuvanting Lipoprotein Conjugate αGalCer-RBD Induces Potent Immunity against SARS-CoV-2 and its Variants of Concern

Wang J, Wen Y, Zhou SH, Zhang HW, Peng XQ, Zhang RY, Yin XG, Qiu H, Gong R, Yang GF, Guo J.

J Med Chem.

Published: 24 January 2022

DOI: https://doi.org/10.1021/acs.jmedchem.1c02000

RBD conjugate vaccine with a built-in TLR1/2 agonist is highly immunogenic against SARS-CoV-2 and variants of concern

Zhou SH, Zhang RY, Zhang HW, Liu YL, Wen Y, Wang J, Li YT, You ZW, Yin XG, Qiu H, Gong R, Yang GF, Guo J.

Chem Commun (Camb).

Published: 18 January 2022

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Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection

Zhang S, Pei R, Li M, Su H, Sun H, Ding Y, Su M, Huang C, Chen X, Du Z, Jin C, Zang Y, Li J, Xu Y, Chen X, Zhang B, Ding K.

Carbohydr Polym.

Published: 1 January 2022

DOI: https://doi.org/10.1016/j.carbpol.2021.118779

Establishment of Human Pluripotent Stem Cell-Derived Skin Organoids Enabled Pathophysiological Model of SARS-CoV-2 Infection

Ma J, Liu J, Gao D, Li X, Zhang Q, Lv L, Wang Y, Li J, Zhu Y, Wu Z, Hu H, Li Y, Ma L, Liu Q, Hu Z, Zhang S, Zhou Y, Wang M, Leng L.

Adv Sci (Weinh).

Published: 31 December 2021

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Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection

Yi Y, Li J, Lai X, Zhang M, Kuang Y, Bao YO, Yu R, Hong W, Muturi E, Xue H, Wei H, Li T, Zhuang H, Qiao X, Xiang K, Yang H, Ye M.

J Adv Res.

Published: 26 November 2021

DOI: https://doi.org/10.1016/j.jare.2021.11.012

The high diversity of SARS-CoV-2-related coronaviruses in pangolins alters potential ecological risks

Peng MS, Li JB, Cai ZF, Liu H, Tang X, Ying R, Zhang JN, Tao JJ, Yin TT, Zhang T, Hu JY, Wu RN, Zhou ZY, Zhang ZG, Yu L, Yao YG, Shi ZL, Lu XM, Lu J, Zhang YP.

Zool Res.

Published: 18 November 2021

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Evaluating the virucidal activity of four disinfectants against SARS-CoV-2

Huang Y, Xiao S, Song D, Yuan Z.

Am J Infect Control.

Published: 12 November 2021

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Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines

Liu J, Wang J, Xu J, Xia H, Wang Y, Zhang C, Chen W, Zhang H, Liu Q, Zhu R, Shi Y, Shen Z, Xing Z, Gao W, Zhou L, Shao J, Shi J, Yang X, Deng Y, Wu L, Lin Q, Zheng C, Zhu W, Wang C, Sun YE, Liu Z.

Cell Discov.

Published: 26 October 2021

DOI: https://doi.org/10.1038/s41421-021-00329-3

Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice

Li JQ, Zhang ZR, Zhang HQ, Zhang YN, Zeng XY, Zhang QY, Deng CL, Li XD, Zhang B, Ye HQ.

Signal Transduct Target Ther.

Published: 25 October 2021

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Epidemiology of Viruses Causing Pediatric Community Acquired Pneumonia in Shanghai During 2010-2020: What Happened Before and After the COVID-19 Outbreak?

Li F, Zhang Y, Shi P, Cao L, Su L, Zhang Y, Peng K, Lu R, Tan W, Shen J.

Infect Dis Ther.

Published: 25 October 2021

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Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2

Xie Y, Yin W, Zhang Y, Shang W, Wang Z, Luan X, Tian G, Aisa HA, Xu Y, Xiao G, Li J, Jiang H, Zhang S, Zhang L, Xu HE, Shen J.

Cell Res.

Published: 28 September 2021

DOI: https://doi.org/10.1038/s41422-021-00570-1

Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients

Yu Y, Wang M, Zhang X, Li S, Lu Q, Zeng H, Hou H, Li H, Zhang M, Jiang F, Wu J, Ding R, Zhou Z, Liu M, Si W, Zhu T, Li H, Ma J, Gu Y, She G, Li X, Zhang Y, Peng K, Huang W, Liu W, Wang Y.

Signal Transduct Target Ther.

Published: 24 September 2021

DOI: https://doi.org/10.1038/s41392-021-00759-1

SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism

Jing Y, Luo L, Chen Y, Westerberg LS, Zhou P, Xu Z, Herrada AA, Park CS, Kubo M, Mei H, Hu Y, Lee PP, Zheng B, Sui Z, Xiao W, Gong Q, Lu Z, Liu C.

Signal Transduct Target Ther.

Published: 22 September 2021

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RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates

Pan X, Shi J, Hu X, Wu Y, Zeng L, Yao Y, Shang W, Liu K, Gao G, Guo W, Peng Y, Chen S, Gao X, Peng C, Rao J, Zhao J, Gong C, Zhou H, Lu Y, Wang Z, Hu X, Cong W, Fang L, Yan Y, Zhang J, Xiong H, Yi J, Yuan Z, Zhou P, Shan C, Xiao G.

Cell Discov.

Published: 7 September 2021

DOI: https://doi.org/10.1038/s41421-021-00320-y

Increased morbidity of obese mice infected with mouse-adapted SARS-CoV-2

Zhang YN, Zhang ZR, Zhang HQ, Li XD, Li JQ, Zhang QY, Liu J, Li Q, Deng CL, Shi ZL, Yuan ZM, Ye HQ, Zhang B.

Cell Discov.

Published: 25 August 2021

DOI: https://doi.org/10.1038/s41421-021-00305-x

Systematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy

Ma ML, Shi DW, Li Y, Hong W, Lai DY, Xue JB, Jiang HW, Zhang HN, Qi H, Meng QF, Guo SJ, Xia DJ, Hu JJ, Liu S, Li HY, Zhou J, Wang W, Yang X, Fan XL, Lei Q, Chen WJ, Li CS, Yang XM, Xu SH, Wei HP, Tao SC.

Cell Discov.

Published: 17 August 2021

DOI: https://doi.org/10.1038/s41421-021-00309-7

Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients

Wang Y, Zhu X, Jiang XM, Guo J, Fu Z, Zhou Z, Yang P, Guo H, Guo X, Liang G, Zeng P, Xiao G, Ma J, Yin X, Zhang LK, Yan C, Zhang CY.

Signal Transduct Target Ther.

Published: 11 August 2021

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Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics

Zhao S, Zhang H, Yang X, Zhang H, Chen Y, Zhan Y, Zhang X, Jiang R, Liu M, Liu L, Chen L, Tang W, Peng C, Gao X, Zhang Z, Shi Z, Gong R.

Nat Commun.

Published: 9 August 2021

DOI: https://doi.org/10.1038/s41467-021-25153-x

Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein

Wang L, Wu Y, Yao S, Ge H, Zhu Y, Chen K, Chen WZ, Zhang Y, Zhu W, Wang HY, Guo Y, Ma PX, Ren PX, Zhang XL, Li HQ, Ali MA, Xu WQ, Jiang HL, Zhang LK, Zhu LL, Ye Y, Shang WJ, Bai F.

Acta Pharmacol Sin.

Published: 4 August 2021

DOI: https://doi.org/10.1038/s41401-021-00735-z

Direct Evidence of Active SARS-CoV-2 Replication in the Intestine

Qian Q, Fan L, Liu W, Li J, Yue J, Wang M, Ke X, Yin Y, Chen Q, Jiang C.

Clin Infect Dis.

Published: 2 August 2021

DOI: https://doi.org/10.1093/cid/ciaa925

Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries

Pan Y, Du J, Liu J, Wu H, Gui F, Zhang N, Deng X, Song G, Li Y, Lu J, Wu X, Zhan S, Jing Z, Wang J, Yang Y, Liu J, Chen Y, Chen Q, Zhang H, Hu H, Duan K, Wang M, Wang Q, Yang X.

Cell Discov.

Published: 27 July 2021

DOI: https://doi.org/10.1038/s41421-021-00295-w

Immunogenicity and safety of a recombinant fusion protein vaccine (V-01) against coronavirus disease 2019 in healthy adults: a randomized, double-blind, placebo-controlled, phase II trial

Shu YJ, He JF, Pei RJ, He P, Huang ZH, Chen SM, Ou ZQ, Deng JL, Zeng PY, Zhou J, Min YQ, Deng F, Peng H, Zhang Z, Wang B, Xu ZH, Guan WX, Hu ZY, Zhang JK.

Chin Med J (Engl).

Published: 22 July 2021

DOI: https://doi.org/10.1097/CM9.0000000000001702

Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates

Wang Y, Fang S, Wu Y, Cheng X, Zhang LK, Shen XR, Li SQ, Xu JR, Shang WJ, Gao ZB, Xia BQ.

Acta Pharmacol Sin.

Published: 22 July 2021

DOI: https://doi.org/10.1038/s41401-021-00732-2

A non-RBM targeted RBD specific antibody neutralizes SARS-CoV-2 inducing S1 shedding

Long Y, Song S, Luo F, Han X, Hu C, Wang Y, Li S, Wang W, Zhang H, Zhang B, Li T, Jin A.

Biochem Biophys Res Commun.

Published: 20 July 2021

DOI: https://doi.org/10.1016/j.bbrc.2021.07.062

Rapid determination of infectious SARS-CoV-2 in PCR-positive samples by SDS-PMA assisted RT-qPCR

Hong W, Xiong J, Nyaruaba R, Li J, Muturi E, Liu H, Yu J, Yang H, Wei H.

Sci Total Environ.

Published: 17 July 2021

DOI: https://doi.org/10.1016/j.scitotenv.2021.149085

Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation

Wang W, Li SS, Xu XF, Yang C, Niu XG, Yin SX, Pan XY, Xu W, Hu GD, Wang C, Liu SW.

Acta Pharmacol Sin.

Published: 15 July 2021

DOI: https://doi.org/10.1038/s41401-021-00714-4

Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants

Qu Y, Zhang X, Wang M, Sun L, Jiang Y, Li C, Wu W, Chen Z, Yin Q, Jiang X, Liu Y, Li C, Li J, Ying T, Li D, Zhan F, Wang Y, Guan W, Wang S, Liang M.

Virol Sin.

Published: 5 July 2021

DOI: https://doi.org/10.1007/s12250-021-00409-4

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18 years or older: A randomized, double-blind, placebo-controlled, phase 1/2 trial

Guo W, Duan K, Zhang Y, Yuan Z, Zhang YB, Wang Z, Zhao D, Zhang H, Xie Z, Li X, Peng C, Zhang W, Yang Y, Chen W, Gao X, You W, Wang XW, Shi Z, Wang Y, Yang XQ, Zhang L, Huang L, Wang Q, Lu J, Yang YL, Guo J, Zhou W, Wan X, Wu C, Wang W, Du J, Nian X, Li XH, Huang S, Shen S, Xia S, Pan A, Yang X.

EClinicalMedicine.

Published: 7 July 2021

DOI: https://doi.org/10.1016/j.eclinm.2021.101010

Safety and immunogenicity of a recombinant interferon-armed RBD dimer vaccine (V-01) for COVID-19 in healthy adults: A randomised, double-blind, placebo-controlled, phase I trial

Liao Y, Li Y, Pei R, Fang X, Zeng P, Fan R, Ou Z, Deng J, Zhou J, Guan W, Min Y, Deng F, Peng H, Zhang Z, Feng C, Xin B, He J, Hu Z, Zhang J.

Emerg Microbes Infect.

Published: 1 July 2021

DOI: https://doi.org/10.1080/22221751.2021.1951126

SARS-CoV-2 NSP12 protein is not an IFN-β antagonist

Li A, Zhao K, Zhang B, Hua R, Fang Y, Jiang W, Zhang J, Hui L, Zheng Y, Li Y, Zhu C, Wang PH, Peng K, Xia Y.

J Virol.

Published: 16 June 2021

DOI: https://doi.org/10.1128/JVI.00747-21

Declining Levels of Neutralizing Antibodies Against SARS-CoV-2 in Convalescent COVID-19 Patients One Year Post Symptom Onset

Xiang T, Liang B, Fang Y, Lu S, Li S, Wang H, Li H, Yang X, Shen S, Zhu B, Wang B, Wu J, Liu J, Lu M, Yang D, Dittmer U, Trilling M, Deng F, Zheng X.

Front Immunol.

Published: 16 June 2021

DOI: https://doi.org/10.3389/fimmu.2021.708523

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

Su H, Yao S, Zhao W, Zhang Y, Liu J, Shao Q, Wang Q, Li M, Xie H, Shang W, Ke C, Feng L, Jiang X, Shen J, Xiao G, Jiang H, Zhang L, Ye Y, Xu Y.

Nat Commun.

Published: 15 June 2021

DOI: https://doi.org/10.1038/s41467-021-23751-3

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target

Xia B, Shen X, He Y, Pan X, Liu FL, Wang Y, Yang F, Fang S, Wu Y, Duan Z, Zuo X, Xie Z, Jiang X, Xu L, Chi H, Li S, Meng Q, Zhou H, Zhou Y, Cheng X, Xin X, Jin L, Zhang HL, Yu DD, Li MH, Feng XL, Chen J, Jiang H, Xiao G, Zheng YT, Zhang LK, Shen J, Li J, Gao Z.

Cell Res.

Published: 10 June 2021

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Consecutive Monitoring of Interleukin-6 Is Needed for COVID-19 Patients

Chen X, Zhou J, Chen C, Hou B, Ali A, Li F, Hua Z, Wu Y, Yang Q, Chen M, Zhang R, Huang Q, Ding J, Zhang XE, Men D.

Virol Sin.

Published: 7 June 2021

DOI: https://doi.org/10.1007/s12250-021-00425-4

Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection

Wang H, Yuan Y, Xiao M, Chen L, Zhao Y, Haiwei Zhang, Long P, Zhou Y, Xu X, Lei Y, Bihao Wu, Diao T, Cai H, Liu L, Shao Z, Wang J, Bai Y, Wang K, Peng M, Liu L, Han S, Mei F, Cai K, Lei Y, Pan A, Wang C, Gong R, Li X, Wu T.

Cell Mol Immunol.

Published: 7 June 2021

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Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19

Yang J, Zhong M, Zhang E, Hong K, Yang Q, Zhou D, Xia J, Chen YQ, Sun M, Zhao B, Xiang J, Liu Y, Han Y, Xu M, Zhou X, Huang C, Shang Y, Yan H.

J Mol Cell Biol.

Published: 6 June 2021

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Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 M^pro

Wang Z, Zhao Y, Wang Q, Xing Y, Feng L, Kong J, Peng C, Zhang L, Yang H, Lu M.

Signal Transduct Target Ther.

Published: 1 June 2021

DOI: https://doi.org/10.1038/s41392-021-00639-8.

Clinicopathologic Features of COVID-19: A Case Report and Value of Forensic Autopsy in Studying SARS-CoV-2 Infection

Ren L, Liu Q, Wang R, Chen R, Ao Q, Wang X, Zhang J, Deng F, Feng Y, Wang G, Zhou Y, Li L, Liu L.

Am J Forensic Med Pathol.

Published: 1 June 2021

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From SARS, MERS to COVID-19: A journey to understand bat coronaviruses

Shi Z.

Bull Acad Natl Med.

Published: 28 May 2021

DOI: https://doi.org/10.1016/j.banm.2021.05.008

SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication

Zheng ZQ, Wang SY, Xu ZS, Fu YZ, Wang YY.

Cell Discov.

Published: 25 May 2021

DOI: https://doi.org/10.1038/s41421-021-00275-0

Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives

Amporndanai K, Meng X, Shang W, Jin Z, Rogers M, Zhao Y, Rao Z, Liu ZJ, Yang H, Zhang L, O'Neill PM, Samar Hasnain S.

Nat Commun.

Published: 24 May 2021

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The SARS-CoV-2 subgenome landscape and its novel regulatory features

Wang D, Jiang A, Feng J, Li G, Guo D, Sajid M, Wu K, Zhang Q, Ponty Y, Will S, Liu F, Yu X, Li S, Liu Q, Yang XL, Guo M, Li X, Chen M, Shi ZL, Lan K, Chen Y, Zhou Y.

Mol Cell.

Published: 20 May 2021

DOI: https://doi.org/10.1016/j.molcel.2021.02.036

Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses

Yang Y, Wang X, Du RH, Zhang W, Si HR, Zhu Y, Shen XR, Li Q, Li B, Men D, Zhou YN, Wang H, Tong XL, Zhang XE, Shi ZL, Zhou P.

Emerg Microbes Infect.

Published: 18 May 2021

DOI: https://doi.org/10.1080/22221751.2021.1919032

Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq

He B, Liu S, Wang Y, Xu M, Cai W, Liu J, Bai W, Ye S, Ma Y, Hu H, Meng H, Sun T, Li Y, Luo H, Shi M, Du X, Zhao W, Chen S, Yang J, Zhu H, Jie Y, Yang Y, Guo D, Wang Q, Liu Y, Yan H, Wang M, Chen YQ.

Signal Transduct Target Ther.

Published: 17 May 2021

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Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice

Huang K, Zhang Y, Hui X, Zhao Y, Gong W, Wang T, Zhang S, Yang Y, Deng F, Zhang Q, Chen X, Yang Y, Sun X, Chen H, Tao YJ, Zou Z, Jin M.

EBioMedicine.

Published: 14 May 2021

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Environmental surveillance of SARS-CoV-2 RNA in wastewater systems and related environments in Wuhan: April to May of 2020

Zhao L, Atoni E, Nyaruaba R, Du Y, Zhang H, Donde O, Huang D, Xiao S, Ren N, Ma T, Shu Z, Yuan Z, Tong L, Xia H.

J Environ Sci (China).

Published: 14 May 2021

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Enriched Opportunistic Pathogens Revealed by Metagenomic Sequencing Hint Potential Linkages between Pharyngeal Microbiota and COVID-19

Xiong D, Muema C, Zhang X, Pan X, Xiong J, Yang H, Yu J, Wei H.

Virol Sin.

Published: 12 May 2021

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A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

Guo Y, Huang L, Zhang G, Yao Y, Zhou H, Shen S, Shen B, Li B, Li X, Zhang Q, Chen M, Chen D, Wu J, Fu D, Zeng X, Feng M, Pi C, Wang Y, Zhou X, Lu M, Li Y, Fang Y, Lu YY, Hu X, Wang S, Zhang W, Gao G, Adrian F, Wang Q, Yu F, Peng Y, Gabibov AG, Min J, Wang Y, Huang H, Stepanov A, Zhang W, Cai Y, Liu J, Yuan Z, Zhang C, Lou Z, Deng F, Zhang H, Shan C, Schweizer L, Sun K, Rao Z.

Nat Commun.

Published: 11 May 2021

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Viral dynamics and antibody responses in people with asymptomatic SARS-CoV-2 infection

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Published: 10 May 2021

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Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

Fu D, Zhang G, Wang Y, Zhang Z, Hu H, Shen S, Wu J, Li B, Li X, Fang Y, Liu J, Wang Q, Zhou Y, Wang W, Li Y, Lu Z, Wang X, Nie C, Tian Y, Chen D, Wang Y, Zhou X, Wang Q, Yu F, Zhang C, Deng C, Zhou L, Guan G, Shao N, Lou Z, Deng F, Zhang H, Chen X, Wang M, Liu L, Rao Z, Guo Y.

PLoS Biol.

Published: 7 May 2021

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SARS-CoV-2 replicon for high-throughput antiviral screening

Zhang QY, Deng CL, Liu J, Li JQ, Zhang HQ, Li N, Zhang YN, Li XD, Zhang B, Xu Y, Ye HQ.

J Gen Virol.

Published: 6 May 2021

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The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

Zhang Y, Sun H, Pei R, Mao B, Zhao Z, Li H, Lin Y, Lu K.

Cell Discov.

Published: 4 May 2021

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SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism

Shen S, Zhang J, Fang Y, Lu S, Wu J, Zheng X, Deng F.

J Hematol Oncol.

Published: 29 April 2021

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A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors

Ren PX, Shang WJ, Yin WC, Ge H, Wang L, Zhang XL, Li BQ, Li HL, Xu YC, Xu EH, Jiang HL, Zhu LL, Zhang LK, Bai F.

Acta Pharmacol Sin.

Published: 27 April 2021

DOI: https://doi.org/10.1038/s41401-021-00668-7

Analysis of the Long-Term Impact on Cellular Immunity in COVID-19-Recovered Individuals Reveals a Profound NKT Cell Impairment

Liu J, Yang X, Wang H, Li Z, Deng H, Liu J, Xiong S, He J, Feng X, Guo C, Wang W, Zelinskyy G, Trilling M, Sutter K, Senff T, Menne C, Timm J, Zhang Y, Deng F, Lu Y, Wu J, Lu M, Yang D, Dittmer U, Wang B, Zheng X.

mBio.

Published: 27 April 2021

DOI: https://doi.org/10.1128/mBio.00085-21

Genetic Mutation of SARS-CoV-2 during Consecutive Passages in Permissive Cells

Chen Y, Liu MQ, Luo Y, Jiang RD, Si HR, Zhu Y, Li B, Shen XR, Lin HF, Zhao K, Hu B, Shi ZL, Yang XL.

Virol Sin.

Published: 26 April 2021

DOI: https://doi.org/10.1007/s12250-021-00384-w

Genetic Mutation of SARS-CoV-2 during Consecutive Passages in Permissive Cells

Chen Y, Liu MQ, Luo Y, Jiang RD, Si HR, Zhu Y, Li B, Shen XR, Lin HF, Zhao K, Hu B, Shi ZL, Yang XL.

Virol Sin.

Published: 26 April 2021

DOI: https://doi.org/10.1007/s12250-021-00384-w

Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses

Yang Y, Wang X, Du RH, Zhang W, Si HR, Zhu Y, Shen XR, Li Q, Li B, Men D, Zhou YN, Wang H, Tong XL, Zhang XE, Shi ZL, Zhou P.

Emerg Microbes Infect.

Published: 19 April 2021

DOI: https://doi.org/10.1080/22221751.2021.1919032

Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

Dai W, Jochmans D, Xie H, Yang H, Li J, Su H, Chang D, Wang J, Peng J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L, Xu Y, Neyts J, Liu H.

J Med Chem.

Published: 19 April 2021

DOI: https://doi.org/10.1021/acs.jmedchem.0c02258

High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors

Zhao Y, Du X, Duan Y, Pan X, Sun Y, You T, Han L, Jin Z, Shang W, Yu J, Guo H, Liu Q, Wu Y, Peng C, Wang J, Zhu C, Yang X, Yang K, Lei Y, Guddat LW, Xu W, Xiao G, Sun L, Zhang L, Rao Z, Yang H.

Protein Cell.

Published: 17 April 2021

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Inactivating SARS-CoV-2 by electrochemical oxidation

Tu Y, Tang W, Yu L, Liu Z, Liu Y, Xia H, Zhang H, Chen S, Wu J, Cui X, Zhang J, Wang F, Hu Y, Deng D.

Sci Bull (Beijing).

Published: 15 April 2021

DOI: https://doi.org/10.1016/j.scib.2020.12.025

Rapid Acquisition of High-Quality SARS-CoV-2 Genome via Amplicon-Oxford Nanopore Sequencing

Yan Y, Wu K, Chen J, Liu H, Huang Y, Zhang Y, Xiong J, Quan W, Wu X, Liang Y, He K, Jia Z, Wang D, Liu D, Wei H, Chen J.

Virol Sin.

Published: 13 April 2021

DOI: https://doi.org/10.1007/s12250-021-00378-8

Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates

Yao YF, Wang ZJ, Jiang RD, Hu X, Zhang HJ, Zhou YW, Gao G, Chen Y, Peng Y, Liu MQ, Zhang YN, Min J, Lu J, Gao XX, Guo J, Peng C, Shen XR, Li Q, Zhao K, Yang L, Wan X, Zhang B, Wang WH, Wu J, Zhou P, Yang XL, Shen S, Shan C, Yuan ZM, Shi ZL.

Virol Sin.

Published: 9 April 2021

DOI: https://doi.org/10.1007/s12250-021-00376-w

Stability of SARS-CoV-2 on the Surfaces of Three Meats in the Setting That Simulates the Cold Chain Transportation

Feng XL, Li B, Lin HF, Zheng HY, Tian RR, Luo RH, Liu MQ, Jiang RD, Zheng YT, Shi ZL, Bi YH, Yang XL.

Virol Sin.

Published: 8 April 2021

DOI: https://doi.org/10.1007/s12250-021-00367-x

Reviving chloroquine for anti-SARS-CoV-2 treatment with cucurbit[7]uril-based supramolecular formulation

Kwong CHT, Mu J, Li S, Fang Y, Liu Q, Zhang X, Kam H, Lee SMY, Chen Y, Deng F, Zhou X, Wang R.

Chin Chem Lett.

Published: 3 April 2021

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Ozone Water Is an Effective Disinfectant for SARS-CoV-2

Hu X, Chen Z, Su Z, Deng F, Chen X, Yang Q, Li P, Chen Q, Ma J, Guan W, Pei R, Wang Y.

Virol Sin.

Published: 31 March 2021

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Two-Step Reverse Transcription Droplet Digital PCR Protocols for SARS-CoV-2 Detection and Quantification

Nyaruaba R, Li X, Mwaliko C, Li C, Mwau M, Odiwour N, Muturi E, Muema C, Li J, Yu J, Wei H.

J Vis Exp.

Published: 31 March 2021

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SARS-CoV-2 cell tropism and multiorgan infection

Jia Liu, Yufeng Li, Qian Liu, Qun Yao, Xi Wang, Huanyu Zhang, Rong Chen, Liang Ren, Juan Min, Fei Deng, Bing Yan, Liang Liu, Zhihong Hu, Manli Wang & Yiwu Zhou

Cell Discovery

Published: 23 March 2021

DOI: https://doi.org/10.1038/s41421-021-00249-2

SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

Jun Wu, Boyun Liang, Cunrong Chen, Hua Wang, Yaohui Fang, Shu Shen, Xiaoli Yang, Baoju Wang, Liangkai Chen, Qi Chen, Yang Wu, Jia Liu, Xuecheng Yang, Wei Li, Bin Zhu, Wenqing Zhou, Huan Wang, Sumeng Li, Sihong Lu, Di Liu, Huadong Li, Adalbert Krawczyk, Mengji Lu, Dongliang Yang, Fei Deng, Ulf Dittmer, Mirko Trilling & Xin Zheng

Nat Commun.

Published: 22 March 2021

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Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality

Ali A, Noman M, Guo Y, Liu X, Zhang R, Zhou J, Zheng Y, Zhang XE, Qi Y, Chen X, Men D.

Sci Rep.

Published: 16 March 2021

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Yin W, Luan X, Li Z, Zhou Z, Wang Q, Gao M, Wang X, Zhou F, Shi J, You E, Liu M, Wang Q, Jiang Y, Jiang H, Xiao G, Zhang L, Yu X, Zhang S, Eric Xu H.

Nat Struct Mol Biol.

Published: 5 March 2021

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Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months

Zheng Y, Zhang Q, Ali A, Li K, Shao N, Zhou X, Ye Z, Chen X, Cao S, Cui J, Zhou J, Wang D, Hou B, Li M, Cui M, Deng L, Sun X, Zhang Q, Yang Q, Li Y, Wang H, Lei Y, Yu B, Cheng Y, Tong X, Men D, Zhang XE.

Virol Sin.

Published: 4 March 2021

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Point-of-care test system for detection of immunoglobulin-G and -M against nucleocapsid protein and spike glycoprotein of SARS-CoV-2

Peng T, Sui Z, Huang Z, Xie J, Wen K, Zhang Y, Huang W, Mi W, Peng K, Dai X, Fang X.

Sens Actuators B Chem.

Published: 15 March 2021

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Contribution of temperature increase to restrain the transmission of COVID-19

Ren M, Pei R, Jiangtulu B, Chen J, Xue T, Shen G, Yuan X, Li K, Lan C, Chen Z, Chen X, Wang Y, Jia X, Li Z, Rashid A, Prapamontol T, Zhao X, Dong Z, Zhang Y, Zhang L, Ye R, Li Z, Guan W, Wang B.

Innovation (N Y)

Published: 28 February 2021

DOI: https://doi.org/10.1016/j.xinn.2020.100071

Longitudinal profile of laboratory parameters and their application in the prediction for fatal outcome among patients infected with SARS-CoV-2: a retrospective cohort study

Zeng HL, Lu QB, Yang Q, Wang X, Yue DY, Zhang LK, Li H, Liu W, Li HJ.

Clin Infect Dis.

Published: 16 February 2021

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SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO

Wu J, Shi Y, Pan X, Wu S, Hou R, Zhang Y, Zhong T, Tang H, Du W, Wang L, Wo J, Mu J, Qiu Y, Yang K, Zhang LK, Ye BC, Qi N.

Cell Rep.

Published: 16 February 2021

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Axial chiral binaphthoquinone and perylenequinones from the stromata of hypocrella bambusae are SARS-CoV-2 entry inhibitors

Li YT, Yang C, Wu Y, Lv JJ, Feng X, Tian X, Zhou Z, Pan X, Liu S, Tian LW.

J Nat Prod.

Published: 9 February 2021

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Discovery and structural optimization of 3-O-β-chacotriosyl oleanane-type triterpenoids as potent entry inhibitors of SARS-CoV-2 virus infections

Li H, Cheng C, Li S, Wu Y, Liu Z, Liu M, Chen J, Zhong Q, Zhang X, Liu S, Song G.

Eur J Med Chem.

Published: 8 February 2021

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Effective virus-neutralizing activities in antisera from the first wave of severe COVID-19 survivors

Han Y, Liu P, Qiu Y, Zhou J, Liu Y, Hu X, Yang Q, Huang R, Wen X, Song H, Yu P, Yang M, Zhang J, Liu WJ, Peng K, Wu G, Zhang D, Zhou X, Wu Y.

JCI Insight

Published: 21 January 2021

DOI: https://doi.org/10.1172/jci.insight.146267

Profiling of the immune repertoire in COVID-19 patients with mild, severe, convalescent, or retesting-positive status

Zhou Y, Zhang J, Wang D, Wang D, Guan W, Qin J, Xu X, Fang J, Fu B, Zheng X, Wang D, Zhao H, Chen X, Tian Z, Xu X, Wang G, Wei H.

J Autoimmun.

Published: 14 January 2021

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Zhou P, Shi ZL.

Science

Published: 8 January 2021

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Pathological features of COVID-19-associated liver injury-a preliminary proteomics report based on clinical samples

Leng L, Cao R, Ma J, Lv L, Li W, Zhu Y, Wu Z, Wang M, Zhou Y, Zhong W.

Signal Transduct Target Ther.

Published: 8 January 2021

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AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells

Wang S, Qiu Z, Hou Y, Deng X, Xu W, Zheng T, Wu P, Xie S, Bian W, Zhang C, Sun Z, Liu K, Shan C, Lin A, Jiang S, Xie Y, Zhou Q, Lu L, Huang J, Li X.

Cell Res.

Published: 8 January 2021

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Developing multiplex ddPCR assays for SARS-CoV-2 detection based on probe mix and amplitude based multiplexing

Nyaruaba R, Li C, Mwaliko C, Mwau M, Odiwuor N, Muturi E, Muema C, Xiong J, Li J, Yu J, Wei H.

Expert Rev Mol Diagn.

Published: 30 December 2020

DOI: https://doi.org/10.1080/14737159.2021.1865807

Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension

Zhang LK, Sun Y, Zeng H, Wang Q, Jiang X, Shang WJ, Wu Y, Li S, Zhang YL, Hao ZN, Chen H, Jin R, Liu W, Li H, Peng K, Xiao G.

Cell Discov.

Published: 22 December 2020

DOI: https://doi.org/10.1038/s41421-020-00235-0

Epidemiological, clinical and serological characteristics of children with coronavirus disease 2019 in Wuhan: a single-centered, retrospective study

Luo D, Xia Z, Li H, Tu D, Wang T, Zhang W, Peng L, Yi W, Zhang S, Shu J, Xu H, Li Y, Shi B, Huang C, Tang W, Xiao S, Shu X, Liu Y, Zhang Y, Guo S, Yu Z, Wang B, Gao Y, Hu Q, Wang H, Song X, Mei H, Zhou X, Zheng Z.

Virol Sin.

Published: 22 December 2020

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Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection

Pei R, Feng J, Zhang Y, Sun H, Li L, Yang X, He J, Xiao S, Xiong J, Lin Y, Wen K, Zhou H, Chen J, Rong Z, Chen X.

Protein Cell.

Published: 12 December 2020

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Low toxicity and high immunogenicity of an inactivated vaccine candidate against COVID-19 in different animal models

Wang ZJ, Zhang HJ, Lu J, Xu KW, Peng C, Guo J, Gao XX, Wan X, Wang WH, Shan C, Zhang SC, Wu J, Yang AN, Zhu Y, Xiao A, Zhang L, Fu L, Si HR, Cai Q, Yang XL, You L, Zhou YP, Liu J, Pang DQ, Jin WP, Zhang XY, Meng SL, Sun YX, Desselberger U, Wang JZ, Li XG, Duan K, Li CG, Xu M, Shi ZL, Yuan ZM, Yang XM, Shen S.

Emerg Microbes Infect.

Published: 26 November 2020

DOI: https://doi.org/10.1080/22221751.2020.1852059

Evaluation of saliva as an alternative diagnostic specimen source for SARS-CoV-2 detection by RT-dPCR

Sui Z, Zhang Y, Tu J, Xie J, Huang W, Peng T, Dong L, Yang J, Ouyang Y, Liu S, Li L, Wang Z, Peng K, Fang X, Dai X.

J Infect.

Published: 25 November 2020

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Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin

Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL.

Nature

Published: 17 November 2020

DOI: https://doi.org/10.1038/s41586-020-2951-z

Prolonged shedding of severe acute respiratory syndrome coronavirus 2 in patients with COVID-19

Li Q, Zheng XS, Shen XR, Si HR, Wang X, Wang Q, Li B, Zhang W, Zhu Y, Jiang RD, Zhao K, Wang H, Shi ZL, Zhang HL, Du RH, Zhou P.

Emerg Microbes Infect.

Published: 16 November 2020

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Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

Wang S, Peng Y, Wang R, Jiao S, Wang M, Huang W, Shan C, Jiang W, Li Z, Gu C, Chen B, Hu X, Yao Y, Min J, Zhang H, Chen Y, Gao G, Tang P, Li G, Wang A, Wang L, Zhang J, Chen S, Gui X, Yuan Z, Liu D.

Nat Commun.

Published: 13 November 2020

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Infection of human sweat glands by SARS-CoV-2

Jia Liu, Yufeng Li, Liang Liu, Xudong Hu, Xi Wang, Hengrui Hu, Zhihong Hu, Yiwu Zhou, Manli Wang

Cell Discovery

Published: 13 November 2020

DOI: https://doi.org/10.1038/s41421-020-00229-y

Baicalein inhibits SARS-CoV-2/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner

Shichao Huang, Yu’e Liu, Yanan Zhang, Ru Zhang, ChengJie Zhu, Lihong Fan, Gang Pei, Bo Zhang, Yufeng Shi

Signal Transduction and Targeted Therapy

Published: 13 November 2020

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High-throughput screening of an FDA-approved drug library identifies inhibitors against arenaviruses and SARS-CoV-2

Wan W, Zhu S, Li S, Shang W, Zhang R, Li H, Liu W, Xiao G, Peng K, Zhang L.

ACS Infect Dis.

Published: 12 November 2020

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Immune responses and residual SARS-CoV-2 in two critically ill COVID-19 patients before and after lung transplantation

Yan Y, Jiang X, Fu J, Huang J, Qiu Y, Ding D, Ge L, Zhang H, Huang L, Lu X, Hu Q.

J Infect.

Published: 12 November 2020

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Detectable serum severe acute respiratory syndrome coronavirus 2 viral load (RNAemia) is closely correlated with drastically elevated interleukin 6 level in critically Ill patients with coronavirus disease 2019

Chen X, Zhao B, Qu Y, Chen Y, Xiong J, Feng Y, Men D, Huang Q, Liu Y, Yang B, Ding J, Li F.

Clin Infect Dis.

Published: 5 November 2020

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Identification of SARS-CoV-2 entry inhibitors among already approved drugs

Li Yang, Rong-juan Pei, Heng Li, Xin-na Ma, Yu Zhou, Feng-hua Zhu, Pei-lan He, Wei Tang, Ye-cheng Zhang, Jin Xiong, Shu-qi Xiao, Xian-kun Tong, Bo Zhang, Jian-ping Zuo

Acta Pharmacol Sin.

Published: 28 October 2020

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SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response

Yu-Zhi Fu, Su-Yun Wang, Zhou-Qin Zheng, Yi Huang, Wei-Wei Li, Zhi-Sheng Xu, Yan-Yi Wang

Cell Mol Immunol.

Published: 27 October 2020

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Plasma proteomics identify biomarkers and pathogenesis of COVID-19

Ting Shu, Wanshan Ning, Di Wu, Jiqian Xu, Qiangqiang Han, Muhan Huang, Xiaojing Zou, Qingyu Yang, Yang Yuan, Yuanyuan Bie, Shangwen Pan, Jingfang Mu, Yang Han, Xiaobo Yang, Hong Zhou, Ruiting Li, Yujie Ren, Xi Chen, Shanglong Yao, Yang Qiu, Ding-Yu Zhang, Yu Xue, You Shang, Xi Zhou

Immunity

Published: 20 October 2020

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Hu B, Guo H, Zhou P, Shi ZL

Nat Rev Microbiol.

Published: 6 October 2020

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Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein

Yang C, Pan X, Xu X, Cheng C, Huang Y, Li L, Jiang S, Xu W, Xiao G, Liu S

Signal Transduct Target Ther.

Published: 6 October 2020

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A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2

Zhe-Rui Zhang, Ya-Nan Zhang, Xiao-Dan Li, Hong-Qing Zhang, Shu-Qi Xiao, Fei Deng, Zhi-Ming Yuan, Han-Qing Ye & Bo Zhang

Signal Transduction and Targeted Therapy

Published: 03 October 2020

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Analysis of the clinical characteristics of 77 COVID-19 deaths

Wang K, Qiu Z, Liu J, Fan T, Liu C, Tian P, Wang Y, Ni Z, Zhang S, Luo J, Liu D, Li W

Sci Rep.

Published: 2 October 2020

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Distribution of airborne SARS-CoV-2 and possible aerosol transmission in Wuhan hospitals, China

Jia Hu, Chengfeng Lei, Zhen Chen, Weihua Liu, Xujuan Hu, Rongjuan Pei, Zhengyuan Su, Fei Deng, Yu Huang, Xiulian Sun, Junji Cao, Wuxiang Guan

National Science Review

Published: 28 September 2020

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A serological survey of SARS-CoV-2 in cat in Wuhan

Zhang Q, Zhang H, Gao J, Huang K, Yang Y, Hui X, He X, Li C, Gong W, Zhang Y, Zhao Y, Peng C, Gao X, Chen H, Zou Z, Shi ZL, Jin M.

Emerg Microbes Infect.

Published: 17 September 2020

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Temporal antibody responses to SARS-CoV-2 in patients of coronavirus disease 2019

Min Huang, Qing-Bin Lu, Han Zhao, Yulan Zhang, Zhiwei Sui, Liqun Fang, Di Liu, Xiulian Sun, Ke Peng, Wei Liu, Wuxiang Guan

Cell Discov.

Published: 15 September 2020

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SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2

Jingfang Mu, Yaohui Fang, Qi Yang, Ting Shu, An Wang, Muhan Huang, Liang Jin, Fei Deng, Yang Qiu, Xi Zhou

Cell Discov.

Published: 15 September 2020

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Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication

Zhen Zhou, Yu Zhou, Xia-Ming Jiang, Yanbo Wang, Xi Chen, Gengfu Xiao, Chen-Yu Zhang, Yongxiang Yi, Lei-Ke Zhang, Liang Li

Cell Discov.

Published: 11 September 2020

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Comparative antiviral efficacy of viral protease inhibitors against the novel SARS-CoV-2 in vitro

Leike Zhang, Jia Liu, Ruiyuan Cao, Mingyue Xu, Yan Wu, Weijuan Shang, Xi Wang, Huanyu Zhang, Xiaming Jiang, Yuan Sun, Hengrui Hu, Yufeng Li, Gang Zou, Min Zhang, Lei Zhao, Wei Li, Xiaojia Guo, Xiaomei Zhuang, Xing-Lou Yang, Zheng-Li Shi, Fei Deng, Zhihong Hu, Gengfu Xiao, Manli Wang, Wu Zhong

Virol Sin.

Published: 10 September 2020

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A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles

Ya-Nan Zhang, Xiao-Dan Li, Zhe-Rui Zhang, Hong-Qing Zhang, Na Li, Jing Liu, Jia-Qi Li, Hua-Jun Zhang, Ze-Jun Wang, Shuo Shen, Zheng-Li Shi, Hong-Ping Wei, Zhi-Ming Yuan, Han-Qing Ye & Bo Zhang

Cell Res.

Published: 25 August 2020

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Characterizing COVID-19 severity, epidemiology and SARS-CoV-2 genotypes in a regional business hub of China

Yan Yan, Bin Liu, Hui Ding, Xu Wang, Yaping Dai, Difei Ding, Hui Yu, Mingchao Sha, Chunyan Lui, Davgadorj Chantsalmaa, Yuanwang Qiu, Lihua Huang, Qinxue Hu

J Infect.

Published: 25 August 2020

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Longitudinal characteristics of T cell responses in asymptomatic SARS-CoV-2 infection

Jingyi Yang, Ejuan Zhang, Maohua Zhong, Qingyu Yang, Ke Hong, Ting Shu, Dihan Zhou, Jie Xiang, Jianbo Xia, Xi Zhou, Dingyu Zhang, Chaolin Huang, You Shang, Huimin Yan

Virol Sin.

Published: 21 August 2020

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An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques

Liqiang Feng, Qian Wang, Chao Shan, Chenchen Yang, Ying Feng, Jia Wu, Xiaolin Liu, Yiwu Zhou, Rendi Jiang, Peiyu Hu, Xinglong Liu, Fan Zhang, Pingchao Li, Xuefeng Niu, Yichu Liu, Xuehua Zheng, Jia Luo, Jing Sun, Yingying Gu, Bo Liu, Yongcun Xu, Chufang Li, Weiqi Pan, Jincun Zhao, Changwen Ke, Xinwen Chen, Tao Xu, Nanshan Zhong, Suhua Guan, Zhiming Yuan, Ling Chen

Nat Commun.

Published: 21 August 2020

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Anti-SARS-CoV-2 potential of artemisinins in vitro

Ruiyuan Cao, Hengrui Hu, Yufeng Li, Xi Wang, Mingyue Xu, Jia Liu, Huanyu Zhang, Yunzheng Yan, Lei Zhao, Wei Li, Tianhong Zhang, Dian Xiao, Xiaojia Guo, Yuexiang Li, Jingjing Yang, Zhihong Hu, Manli Wang, Wu Zhong

ACS Infect Dis.

Published: 18 August 2020

DOI: https://doi.org/10.1021/acsinfecdis.0c00522

Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes: interim analysis of 2 randomized clinical trials

Shengli Xia, Kai Duan, Yuntao Zhang, Dongyang Zhao, Huajun Zhang, Zhiqiang Xie, Xinguo Li, Cheng Peng , Yanbo Zhang, Wei Zhang, Yunkai Yang, Wei Chen, Xiaoxiao Gao, Wangyang You, Xuewei Wang, Zejun Wang, Zhengli Shi, Yanxia Wang, Xuqin Yang, Lianghao Zhang, Lili Huang, Qian Wang, Jia Lu, Yongli Yang, Jing Guo, Wei Zhou, Xin Wan, Cong Wu, Wenhui Wang, Shihe Huang, Jianhui Du, Ziyan Meng, An Pan, Zhiming Yuan, Shuo Shen, Wanshen Guo, Xiaoming Yang

JAMA.

Published: 13 August 2020

DOI: https://doi.org/10.1001/jama.2020.15543

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

Rui Xiong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang, Yongliang Zhao, Yan Wu, Weijuan Shang, Xiaming Jiang, Jiwei Shan, Zihao Shen, Yi Tong, Liuxin Xu, Yu Chen, Yingle Liu, Gang Zou, Dimitri Lavillete, Zhenjiang Zhao, Rui Wang, Lili Zhu, Gengfu Xiao, Ke Lan, Honglin Li, Ke Xu

Protein Cell

Published: 4 August 2020

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Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients

Li-Kun Zhou, Zhen Zhou, Xia-Ming Jiang, Yishan Zheng, Xi Chen, Zheng Fu, Gengfu Xiao, Chen-Yu Zhang, Lei-Ke Zhang, Yongxiang Yi

Cell Discov.

Published: 2 August 2020

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Dynamic changes of antibodies to SARS-CoV-2 in COVID-19 patients at early stage of outbreak

Huaqing Shu, Shuzhen Wang, Shunan Ruan, Yaxin Wang, Jiancheng Zhang, Yin Yuan, Hong Liu, Yongran Wu, Ruiting Li, Shangwen Pan, Yaqi Ouyang, Shiying Yuan, Peng Zhou, You Shang

Virol Sin.

Published: 27 July 2020

DOI: https://doi.org/10.1007/s12250-020-00268-5

Immunological detection of serum antibodies in pediatric medical workers exposed to varying levels of SARS-CoV-2

Danna Tu, Junhua Shu, Xiaoli Wu, Heng Li, Zhi Xia, Yanfang Zhang, Yaohui Fang, Shu Shen, Wuxiang Guan, Hualin Wang, Zhaoxuan Huang, Guirong Wang, Xiaoqin Zhou, Fei Deng

J Infect.

Published: 25 July 2020

DOI: https://doi.org/10.1016/j.jinf.2020.07.023

Immunoglobulin fragment F(ab’)₂ against RBD potently neutralizes SARS-CoV-2 in vitro

Xiaoyan Pan, Pengfei Zhou, Tiejiong Fan, Yan Wu, Jing Zhang, Xiaoyue Shi, Weijuan Shang, Lijuan Fang, Xiaming Jiang, Jian Shi, Yuan Sun, Shaojuan Zhao, Rui Gong, Ze Chen, Gengfu Xiao

Antiviral Research

Published: 10 July 2020

DOI: https://doi.org/10.1016/j.antiviral.2020.104868

Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques

Chao Shan, Yan-Feng Yao, Xing-Lou Yang, Yi-Wu Zhou, Ge Gao, Yun Peng, Lian Yang, Xue Hu, Jin Xiong, Ren-Di Jiang, Hua-Jun Zhang, Xiao-Xiao Gao, Cheng Peng, Juan Min, Ying Chen, Hao-Rui Si, Jia Wu, Peng Zhou, Yan-Yi Wang, Hong-Ping Wei, Wei Pang, Zheng-Fei Hu, Long-Bao Lv, Yong-Tang Zheng, Zheng-Li Shi, Zhi-Ming Yuan

Cell Res.

Published: 7 July 2020

DOI: https://doi.org/10.1038/s41422-020-0364-z

COVID-19: clinical aspects and therapeutics responses

Suliman Khan, Ashaq Ali, Hongwei Shi, Rabeea Siddique, Shabana, Ghulam Nabi, Junjie Hu, Tiejun Wang, Men Dong, Wajid Zaman, Guang Han

Saudi Pharm J.

Published: 3 July 2020

DOI: https://doi.org/10.1016/j.jsps.2020.06.022

SARS-CoV-2 does not replicate in aedes mosquito cells nor present in field-caught mosquitoes from Wuhan

Han Xia, Evans Atoni, Lu Zhao, Nanjie Ren, Doudou Huang, Rongjuan Pei, Zhen Chen, Jin Xiong, Raphael Nyaruaba, Shuqi Xiao, Bo Zhang, Zhiming Yuan

Virol Sin.

Published: 29 June 2020

DOI: https://doi.org/10.1007/s12250-020-00251-0

Nanopore targeted sequencing for the accurate and comprehensive detection of SARS-CoV-2 and other respiratory viruses

Ming Wang, Aisi Fu, Ben Hu, Yongqing Tong, Ran Liu, Zhen Liu, Jiashuang Gu, Bin Xiang, Jianghao Liu, Wen Jiang, Gaigai Shen, Wanxu Zhao, Dong Men, Zixin Deng, Lilei Yu, Wu Wei, Yan Li, Tiangang Liu

Small

Published: 24 June 2020

DOI: https://doi.org/10.1002/smll.202002169

Severe acute respiratory syndrome coronavirus 2-specific antibodies in pets in Wuhan, China

Jianjun Chen, Chaolin Huang, Yanan Zhang, Sai Zhang, Meilin Jin

J Infect.

Published: 21 June 2020

DOI: https://doi.org/10.1016/j.jinf.2020.06.045

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

Chaofu Wang, Jing Xie, Lei Zhao, Xiaochun Fei, Heng Zhang, Yun Tan, Xiu Nie, Luting Zhou, Zhenhua Liu, Yong Ren, Ling Yuan, Yu Zhang, Jinsheng Zhang, Liwei Liang, Xinwei Chen, Xin Liu, Peng Wang, Xiao Han, Xiangqin Weng, Ying Chen, Ting Yu, Xinxin Zhang, Jun Cai, Rong Chen, Zheng-Li Shi, Xiu-Wu Bian

EBioMedicine.

Published: 20 June 2020; 57:102833.

DOI: https://doi.org/10.1016/j.ebiom.2020.102833

Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients

Zhi-Sheng Xu, Ting Shu, Liang Kang, Di Wu, Xing Zhou, Bo-Wei Liao, Xiu-Lian Sun, Xi Zhou, Yan-Yi Wang

Signal Transduct Target Ther.

Published: 19 June 2020; 5(1):100.

DOI: https://doi.org/10.1038/s41392-020-0211-1

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

Yujie Ren, Ting Shu, Di Wu, Jingfang Mu, Chong Wang, Muhan Huang, Yang Han, Xue-Yi Zhang, Wei Zhou, Yang Qiu, Xi Zhou

Cell Mol Immunol.

Published: 18 June 2020

DOI: https://doi.org/10.1038/s41423-020-0485-9

Analysis of 2019 novel coronavirus infection and clinical characteristics of outpatients: An epidemiological study from a fever clinic in Wuhan, China

Yanqiu Wei, Yanjun Lu, Liming Xia, Xianglin Yuan, Gang Li, Xinying Li, Li Liu, Wenhua Liu, Peng Zhou, Cong‐Yi Wang, Huilan Zhang

J Med Virol.

Published: 16 June 2020

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SARS-Coronavirus-2 Nsp13 possesses NTPase and RNA helicase activities that can be inhibited by bismuth salts

Ting Shu, Muhan Huang, Di Wu, Yujie Ren, Xueyi Zhang, Yang Han, Jingfang Mu, Ruibing Wang, Yang Qiu, Ding-Yu Zhang, Xi Zhou

Virol Sin.

Published: 4 June 2020

DOI: https://doi.org/10.1007/s12250-020-00242-1

Co-infection of SARS-CoV-2 and influenza virus in early stage of the COVID-19 epidemic in Wuhan, China

Xin Zheng, Hua Wang, Zhengyuan Su, Wei Li, Dongliang Yang, Fei Deng, Jianjun Chen

J Infect.

Published: 28 May 2020; S0163-4453(20)30319-4

DOI: https://doi.org/10.1016/j.jinf.2020.05.041

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

Rui Shi, Chao Shan, Xiaomin Duan, Zhihai Chen, Peipei Liu, Jinwen Song, Tao Song, Xiaoshan Bi, Chao Han, Lianao Wu, Ge Gao, Xue Hu, Yanan Zhang, Zhou Tong, Weijin Huang, William Jun Liu, Guizhen Wu, Bo Zhang, Lan Wang, Jianxun Qi, Hui Feng, Fu-Sheng Wang, Qihui Wang, George Fu Gao, Zhiming Yuan & Jinghua Yan

Nature

Published: 26 May 2020

DOI: https://doi.org/10.1038/s41586-020-2381-y

Structural basis for RNA replication by the SARS-CoV-2 polymerase

Quan Wang, Jiqin Wu, Haofeng Wang, Yan Gao, Qiaojie Liu, An Mu, Wenxin Ji, Liming Yan, Yan Zhu, Chen Zhu, Xiang Fang, Xiaobao Yang, Yucen Huang, Hailong Gao, Fengjiang Liu, Ji Ge, Qianqian Sun, Xiuna Yang, Wenqing Xu, Zhijie Liu, Haitao Yang, Zhiyong Lou, Biao Jiang, Luke W. Guddat, Peng Gong, Zihe Rao

Cell

Published: 22 May 2020

DOI:https://doi.org/10.1016/j.cell.2020.05.034

Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2

Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Chao Shan, Yi-Wu Zhou, Xu-Rui Shen, Qian Li, Lei Zhang, Yan Zhu, Hao-Rui Si, Qi Wang, Juan Min, Xi Wang, Wei Zhang, Bei Li, Hua-Jun Zhang, Ralph S. Baric, Peng Zhou, Xing-Lou Yang, Zheng-Li Shi

Cell

Published: 21 May 2020

DOI: https://doi.org/10.1016/j.cell.2020.05.027

Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture

Ya-Nan Zhang, Qiu-Yan Zhang, Xiao-Dan Li, Jin Xiong, Shu-Qi Xiao, Zhen Wang, Zhe-Rui Zhang, Cheng-Lin Deng, Xing-Lou Yang, Hong-Ping Wei, Zhi-Ming Yuan, Han-Qing Ye & Bo Zhang

Emerging Microbes & Infections

Published: 20 May 2020

DOI: https://doi.org/10.1080/22221751.2020.1772676

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

Chunyan Yi, Xiaoyu Sun, Jing Ye, Longfei Ding, Meiqin Liu, Zhuo Yang, Xiao Lu, Yaguang Zhang, Liyang Ma, Wangpeng Gu, Aidong Qu, Jianqing Xu, Zhengli Shi, Zhiyang Ling, Bing Sun

Cell Mol Immunol.

Published: 15 May 2020

DOI: https://doi.org/10.1038/s41423-020-0458-z

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

Zhenming Jin, Yao Zhao, Yuan Sun, Bing Zhang, Haofeng Wang, Yan Wu, Yan Zhu, Chen Zhu, Tianyu Hu, Xiaoyu Du, Yinkai Duan, Jing Yu, Xiaobao Yang, Xiuna Yang, Kailin Yang, Xiang Liu, Luke W Guddat, Gengfu Xiao, Leike Zhang, Haitao Yang, Zihe Rao

Nat Struct Mol Biol.

Published: 07 May 2020

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The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro

Xi Wang, Ruiyuan Cao, Huanyu Zhang, Jia Liu, Mingyue Xu, Hengrui Hu, Yufeng Li, Lei Zhao, Wei Li, Xiulian Sun, Xinglou Yang, Zhengli Shi, Fei Deng, Zhihong Hu, Wu Zhong & Manli Wang

Cell Discov.

Published: 02 May 2020

DOI: https://doi.org/10.1038/s41421-020-0169-8

The importance of naturally attenuated SARS-CoV-2 in the fight against COVID-19

Jean Armengaud, Agnès Delaunay-Moisan, Jean-Yves Thuret, Eelco van Anken, Diego Acosta-Alvear, Tomás Aragón, Carolina Arias, Marc Blondel, Ineke Braakman, Jean-Francois Collet, René Courcol, Antoine Danchin, Jean-Francois Deleuze, Jean-Philippe Lavigne, Sophie Lucas, Thomas Michiels, Edward R B Moore, Jonathon Nixon-Abell , Ramon Rossello-Mora , Zheng-Li Shi, Antonio G Siccardi, Roberto Sitia, Daniel Tillett, Kenneth N Timmis, Michel B Toledano, Peter van der Sluijs, Elisa Vicenzi

Environ Microbiol.

Published: 28 April 2020

DOI: https://doi.org/10.1111/1462-2920.15039

Plasma metabolomic and lipidomic alterations associated with COVID-19

Di Wu, Ting Shu, Xiaobo Yang, Jian-Xin Song, Mingliang Zhang, Chengye Yao, Wen Liu, Muhan Huang, Yuan Yu, Qingyu Yang, Tingju Zhu, Jiqian Xu, Jingfang Mu, Yaxin Wang, Hong Wang, Tang Tang, Yujie Ren, Yongran Wu, Shu-Hai Lin, Yang Qiu, Ding-Yu Zhang, You Shang, Xi Zhou

National Science Review

Published: 28 April 2020

DOI: https://doi.org/10.1093/nsr/nwaa086

SARS-CoV-2 infection in children

Xiaoxia Lu, Liqiong Zhang, Hui Du, Jingjing Zhang, Yuan Y Li, Jingyu Qu, Wenxin Zhang, Youjie Wang, Shuangshuang Bao, Ying Li, Chuansha Wu, Hongxiu Liu, Di Liu, Jianbo Shao, Xuehua Peng, Yonghong Yang, Zhisheng Liu, Yun Xiang, Furong Zhang, Rona M Silva, Kent E Pinkerton, Kunling Shen, Han Xiao, Shunqing Xu, Gary W K Wong, Chinese Pediatric Novel Coronavirus Study Team

N Engl J Med.

Published: 23 April 2020

DOI: https://doi.org/10.1056/NEJMc2005073

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Wenhao Dai, Bing Zhang, Xia-Ming Jiang, Haixia Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu, Chunpu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, Xiaobo Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Gengfu Xiao, Hualiang Jiang, Zihe Rao, Lei-Ke Zhang, Yechun Xu, Haitao Yang, Hong Liu

Science

Published: 22 April 2020

DOI: https://doi.org/10.1126/science.abb4489

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

Xiaohua Chen, Binghong Zhao, Yueming Qu, Yurou Chen, Jie Xiong, Yong Feng, Dong Men, Qianchuan Huang, Ying Liu, Bo Yang, Jinya Ding, Feng Li

Clin Infect Dis.

Published: 17 April 2020

DOI: https://doi.org/10.1093/cid/ciaa449

SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells

Jingfang Mu, Jiuyue Xu, Leike Zhang, Ting Shu, Di Wu, Muhan Huang, Yujie Ren, Xufang Li, Qing Geng, Yi Xu, Yang Qiu & Xi Zhou

Sci China Life Sci.

Published: 10 April 2020

DOI: https://doi.org/10.1007/s11427-020-1692-1

Structure of M ^pro from COVID-19 virus and discovery of its inhibitors

Zhenming Jin, Xiaoyu Du, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Leike Zhang, Chao Peng, Yinkai Duan, Jing Yu, Lin Wang, Kailin Yang, Fengjiang Liu, Rendi Jiang, Xinglou Yang, Tian You, Xiaoce Liu, Xiuna Yang, Fang Bai, Hong Liu, Xiang Liu, Luke W. Guddat, Wenqing Xu, Gengfu Xiao, Chengfeng Qin, Zhengli Shi, Hualiang Jiang, Zihe Rao & Haitao Yang

Nature

Published: 9 April 2020

DOI: https://doi.org/10.1038/s41586-020-2223-y

Rapid and visual detection of 2019 novel coronavirus (SARS-CoV-2) by a reverse transcription loop-mediated isothermal amplification assay

C. Yan, J. Cui, L. Huang, B. Du, L. Chen, G. Xue, S. Li, W. Zhang, L. Zhao, Y. Sun, H. Yao, N. Li, H. Zhao, Y. Feng, S. Liu, Q. Zhang, D. Liu, J. Yuan

Clin Microbiol Infect.

Published: 7 April 2020

DOI: https://doi.org/10.1016/j.cmi.2020.04.001

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

Kai Duan, Bende Liu, Cesheng Li, Huajun Zhang, Ting Yu, Jieming Qu, Min Zhou, Li Chen, Shengli Meng, Yong Hu, Cheng Peng, Mingchao Yuan, Jinyan Huang, Zejun Wang, Jianhong Yu, Xiaoxiao Gao, Dan Wang, Xiaoqi Yu, Li Li, Jiayou Zhang, Xiao Wu, Bei Li, Yanping Xu, Wei Chen, Yan Peng, Yeqin Hu, Lianzhen Lin, Xuefei Liu, Shihe Huang, Zhijun Zhou, Lianghao Zhang, Yue Wang, Zhi Zhang, Kun Deng, Zhiwu Xia, Qin Gong, Wei Zhang, Xiaobei Zheng, Ying Liu, Huichuan Yang, Dongbo Zhou, Ding Yu, Jifeng Hou, Zhengli Shi, Saijuan Chen, Zhu Chen, Xinxin Zhang, and Xiaoming Yang

PNAS

Published: 6 April 2020

DOI: https://doi.org/10.1073/pnas.2004168117

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Shuai Xia, Meiqin Liu, Chao Wang, Wei Xu, Qiaoshuai Lan, Siliang Feng, Feifei Qi, Linlin Bao, Lanying Du, Shuwen Liu, Chuan Qin, Fei Sun, Zhengli Shi, Yun Zhu, Shibo Jiang, Lu Lu

Cell Research

Published: 30 March 2020

DOI: https://doi.org/10.1038/s41422-020-0305-x

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

Jia Liu, Ruiyuan Cao, Mingyue Xu, Xi Wang, Huanyu Zhang, Hengrui Hu, Yufeng Li, Zhihong Hu, Wu Zhong & Manli Wang

Cell Discovery

Published: 18 March 2020

DOI: https://doi.org/10.1038/s41421-020-0156-0

Does SARS-CoV-2 has a longer incubation period than SARS and MERS?

Xuan Jiang, Simon Rayner, Min-Hua Luo

J Med Virol.

Published: 24 February 2020

DOI: https://doi.org/10.1002/jmv.25708

A distinct name is needed for the new coronavirus

Shibo Jiang, Zhengli Shi, Yuelong Shu, Jingdong Song, George F Gao, Wenjie Tan and Deyin Guo

Lancet

Published: 19 February 2020

DOI: https://doi.org/10.1016/S0140-6736(20)30419-0

Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes

Wei Zhang, Rong-Hui Du, Bei Li, Xiao-Shuang Zheng, Xing-Lou Yang, Ben Hu, Yan-Yi Wang, Geng-Fu Xiao, Bing Yan, Zheng-Li Shi & Peng Zhou

Emerg Microbes Infect.

Published: 17 February 2020

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Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

Xiaolong Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zhengli Shi, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu &Tianlei Ying

Emerg Microbes Infect.

Published: 17 February 2020

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The first disease X is caused by a highly transmissible acute respiratory syndrome coronavirus

Shibo Jiang & Zheng-Li Shi

Virol Sin.

Published: 14 February 2020

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Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

Shuai Xia, Yun Zhu, Meiqin Liu, Qiaoshuai Lan, Wei Xu, Yanling Wu, Tianlei Ying, Shuwen Liu, Zhengli Shi, Shibo Jiang & Lu Lu

Cell Mol Immunol.

Published: 11 February 2020

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Clinical features and treatment of 2019-nCov pneumonia patients in Wuhan: report of a couple cases

Zhan Zhang, Xiaochen Li, Wei Zhang, Zheng-Li Shi, Zhishui Zheng & Tao Wang

Virol Sin.

Published: 7 February 2020

DOI: https://doi.org/10.1007/s12250-020-00203-8

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong & Gengfu Xiao

Cell Research

Published: 04 February 2020

DOI: https://doi.org/10.1038/s41422-020-0282-0

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Chao-Lin Huang, Hui-Dong Chen, Jing Chen, Yun Luo, Hua Guo, Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Xu-Rui Shen, Xi Wang, Xiao-Shuang Zheng, Kai Zhao, Quan-Jiao Chen, Fei Deng, Lin-Lin Liu, Bing Yan, Fa-Xian Zhan, Yan-Yi Wang, Geng-Fu Xiao & Zheng-Li Shi

Nature

Published: 03 February 2020

DOI: https://doi.org/10.1038/s41586-020-2012-7

An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies

Shibo Jiang, Lanying Du & Zhengli Shi

Emerg Microbes Infect.

Published: 31 January 2020

DOI: https://doi.org/10.1080/22221751.2020.1723441