A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles

Ya-Nan Zhang, Xiao-Dan Li, Zhe-Rui Zhang, Hong-Qing Zhang, Na Li, Jing Liu, Jia-Qi Li, Hua-Jun Zhang, Ze-Jun Wang, Shuo Shen, Zheng-Li Shi, Hong-Ping Wei, Zhi-Ming Yuan, Han-Qing Ye & Bo Zhang

Cell Res.

Published: 25 August 2020

DOI: https://doi.org/10.1038/s41422-020-00405-5

Anti-SARS-CoV-2 potential of artemisinins in vitro

Ruiyuan Cao, Hengrui Hu, Yufeng Li, Xi Wang, Mingyue Xu, Jia Liu, Huanyu Zhang, Yunzheng Yan, Lei Zhao, Wei Li, Tianhong Zhang, Dian Xiao, Xiaojia Guo, Yuexiang Li, Jingjing Yang, Zhihong Hu, Manli Wang, Wu Zhong

ACS Infect Dis.

Published: 18 August 2020

DOI: https://doi.org/10.1021/acsinfecdis.0c00522

Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes: interim analysis of 2 randomized clinical trials

Shengli Xia, Kai Duan, Yuntao Zhang, Dongyang Zhao, Huajun Zhang, Zhiqiang Xie, Xinguo Li, Cheng Peng , Yanbo Zhang, Wei Zhang, Yunkai Yang, Wei Chen, Xiaoxiao Gao, Wangyang You, Xuewei Wang, Zejun Wang, Zhengli Shi, Yanxia Wang, Xuqin Yang, Lianghao Zhang, Lili Huang, Qian Wang, Jia Lu, Yongli Yang, Jing Guo, Wei Zhou, Xin Wan, Cong Wu, Wenhui Wang, Shihe Huang, Jianhui Du, Ziyan Meng, An Pan, Zhiming Yuan, Shuo Shen, Wanshen Guo, Xiaoming Yang

JAMA.

Published: 13 August 2020

DOI: https://doi.org/10.1001/jama.2020.15543

Immunoglobulin fragment F(ab’)₂ against RBD potently neutralizes SARS-CoV-2 in vitro

Xiaoyan Pan, Pengfei Zhou, Tiejiong Fan, Yan Wu, Jing Zhang, Xiaoyue Shi, Weijuan Shang, Lijuan Fang, Xiaming Jiang, Jian Shi, Yuan Sun, Shaojuan Zhao, Rui Gong, Ze Chen, Gengfu Xiao 

Antiviral Research

Published: 10 July 2020

DOI: https://doi.org/10.1016/j.antiviral.2020.104868

Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques

Chao Shan, Yan-Feng Yao, Xing-Lou Yang, Yi-Wu Zhou, Ge Gao, Yun Peng, Lian Yang, Xue Hu, Jin Xiong, Ren-Di Jiang, Hua-Jun Zhang, Xiao-Xiao Gao, Cheng Peng, Juan Min, Ying Chen, Hao-Rui Si, Jia Wu, Peng Zhou, Yan-Yi Wang, Hong-Ping Wei, Wei Pang, Zheng-Fei Hu, Long-Bao Lv, Yong-Tang Zheng, Zheng-Li Shi, Zhi-Ming Yuan

Cell Res.

Published: 7 July 2020; 1-8.

DOI: https://doi.org/10.1038/s41422-020-0364-z

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

Chaofu Wang, Jing Xie, Lei Zhao, Xiaochun Fei, Heng Zhang, Yun Tan, Xiu Nie, Luting Zhou, Zhenhua Liu, Yong Ren, Ling Yuan, Yu Zhang, Jinsheng Zhang, Liwei Liang, Xinwei Chen, Xin Liu, Peng Wang, Xiao Han, Xiangqin Weng, Ying Chen, Ting Yu, Xinxin Zhang, Jun Cai, Rong Chen, Zheng-Li Shi, Xiu-Wu Bian

EBioMedicine.

Published: 20 June 2020; 57:102833.

DOI: https://doi.org/10.1016/j.ebiom.2020.102833

Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients

Zhi-Sheng Xu, Ting Shu, Liang Kang, Di Wu, Xing Zhou, Bo-Wei Liao, Xiu-Lian Sun, Xi Zhou, Yan-Yi Wang

Signal Transduct Target Ther.

Published: 19 June 2020; 5(1):100.

DOI: https://doi.org/10.1038/s41392-020-0211-1

Co-infection of SARS-CoV-2 and influenza virus in early stage of the COVID-19 epidemic in Wuhan, China

Xin Zheng, Hua Wang, Zhengyuan Su, Wei Li, Dongliang Yang, Fei Deng, Jianjun Chen 

J Infect.

Published: 28 May 2020; S0163-4453(20)30319-4

DOI: https://doi.org/10.1016/j.jinf.2020.05.041

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

Rui Shi, Chao Shan, Xiaomin Duan, Zhihai Chen, Peipei Liu, Jinwen Song, Tao Song, Xiaoshan Bi, Chao Han, Lianao Wu, Ge Gao, Xue Hu, Yanan Zhang, Zhou Tong, Weijin Huang, William Jun Liu, Guizhen Wu, Bo Zhang, Lan Wang, Jianxun Qi, Hui Feng, Fu-Sheng Wang, Qihui Wang, George Fu Gao, Zhiming Yuan & Jinghua Yan

Nature

Published: 26 May 2020

DOI: https://doi.org/10.1038/s41586-020-2381-y

Structural basis for RNA replication by the SARS-CoV-2 polymerase

Quan Wang, Jiqin Wu, Haofeng Wang, Yan Gao, Qiaojie Liu, An Mu, Wenxin Ji, Liming Yan, Yan Zhu, Chen Zhu, Xiang Fang, Xiaobao Yang, Yucen Huang, Hailong Gao, Fengjiang Liu, Ji Ge, Qianqian Sun, Xiuna Yang, Wenqing Xu, Zhijie Liu, Haitao Yang, Zhiyong Lou, Biao Jiang, Luke W. Guddat, Peng Gong, Zihe Rao

Cell

Published: 22 May 2020

DOI:https://doi.org/10.1016/j.cell.2020.05.034

Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2

Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Chao Shan, Yi-Wu Zhou, Xu-Rui Shen, Qian Li, Lei Zhang, Yan Zhu, Hao-Rui Si, Qi Wang, Juan Min, Xi Wang, Wei Zhang, Bei Li, Hua-Jun Zhang, Ralph S. Baric, Peng Zhou, Xing-Lou Yang, Zheng-Li Shi

Cell

Published: 21 May 2020

DOI: https://doi.org/10.1016/j.cell.2020.05.027

Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture

Ya-Nan Zhang, Qiu-Yan Zhang, Xiao-Dan Li, Jin Xiong, Shu-Qi Xiao, Zhen Wang, Zhe-Rui Zhang, Cheng-Lin Deng, Xing-Lou Yang, Hong-Ping Wei, Zhi-Ming Yuan, Han-Qing Ye & Bo Zhang

Emerging Microbes & Infections

Published: 20 May 2020

DOI: https://doi.org/10.1080/22221751.2020.1772676

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

Chunyan Yi, Xiaoyu Sun, Jing Ye, Longfei Ding, Meiqin Liu, Zhuo Yang, Xiao Lu, Yaguang Zhang, Liyang Ma, Wangpeng Gu, Aidong Qu, Jianqing Xu, Zhengli Shi, Zhiyang Ling, Bing Sun

Cell Mol Immunol.

Published: 15 May 2020

DOI: https://doi.org/10.1038/s41423-020-0458-z

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

Zhenming Jin, Yao Zhao, Yuan Sun, Bing Zhang, Haofeng Wang, Yan Wu, Yan Zhu, Chen Zhu, Tianyu Hu, Xiaoyu Du, Yinkai Duan, Jing Yu, Xiaobao Yang, Xiuna Yang, Kailin Yang, Xiang Liu, Luke W Guddat, Gengfu Xiao, Leike Zhang, Haitao Yang, Zihe Rao

Nat Struct Mol Biol.

Published: 07 May 2020

DOI: https://doi.org/10.1038/s41594-020-0440-6

The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro

Xi Wang, Ruiyuan Cao, Huanyu Zhang, Jia Liu, Mingyue Xu, Hengrui Hu, Yufeng Li, Lei Zhao, Wei Li, Xiulian Sun, Xinglou Yang, Zhengli Shi, Fei Deng, Zhihong Hu, Wu Zhong & Manli Wang

Cell Discov 6, 28 (2020)

Published: 02 May 2020

DOI: https://doi.org/10.1038/s41421-020-0169-8

The importance of naturally attenuated SARS-CoV-2 in the fight against COVID-19

Jean Armengaud, Agnès Delaunay-Moisan, Jean-Yves Thuret, Eelco van Anken, Diego Acosta-Alvear, Tomás Aragón, Carolina Arias, Marc Blondel, Ineke Braakman, Jean-Francois Collet, René Courcol, Antoine Danchin, Jean-Francois Deleuze, Jean-Philippe Lavigne, Sophie Lucas, Thomas Michiels, Edward R B Moore, Jonathon Nixon-Abell , Ramon Rossello-Mora , Zheng-Li Shi, Antonio G Siccardi, Roberto Sitia, Daniel Tillett, Kenneth N Timmis, Michel B Toledano, Peter van der Sluijs, Elisa Vicenzi

Environ Microbiol.

Published: 28 April 2020

DOI: https://doi.org/10.1111/1462-2920.15039

Plasma metabolomic and lipidomic alterations associated with COVID-19

Di Wu, Ting Shu, Xiaobo Yang, Jian-Xin Song, Mingliang Zhang, Chengye Yao, Wen Liu, Muhan Huang, Yuan Yu, Qingyu Yang, Tingju Zhu, Jiqian Xu, Jingfang Mu, Yaxin Wang, Hong Wang, Tang Tang, Yujie Ren, Yongran Wu, Shu-Hai Lin, Yang Qiu, Ding-Yu Zhang, You Shang, Xi Zhou

National Science Review

Published: 28 April 2020

DOI: https://doi.org/10.1093/nsr/nwaa086

SARS-CoV-2 infection in children 

Xiaoxia Lu, Liqiong Zhang, Hui Du, Jingjing Zhang, Yuan Y Li, Jingyu Qu, Wenxin Zhang, Youjie Wang, Shuangshuang Bao, Ying Li, Chuansha Wu, Hongxiu Liu, Di Liu, Jianbo Shao, Xuehua Peng, Yonghong Yang, Zhisheng Liu, Yun Xiang, Furong Zhang, Rona M Silva, Kent E Pinkerton, Kunling Shen, Han Xiao, Shunqing Xu, Gary W K Wong, Chinese Pediatric Novel Coronavirus Study Team

N Engl J Med., 382(17):1663–1665

Published: 23 April 2020

DOI: https://doi.org/10.1056/NEJMc2005073

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Wenhao Dai, Bing Zhang, Xia-Ming Jiang, Haixia Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu, Chunpu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, Xiaobo Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Gengfu Xiao, Hualiang Jiang, Zihe Rao, Lei-Ke Zhang, Yechun Xu, Haitao Yang, Hong Liu

Science

Published: 22 April 2020

DOI: https://doi.org/10.1126/science.abb4489

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

Xiaohua Chen, Binghong Zhao, Yueming Qu, Yurou Chen, Jie Xiong, Yong Feng, Dong Men, Qianchuan Huang, Ying Liu, Bo Yang, Jinya Ding, Feng Li

Clin Infect Dis.

Published: 17 April 2020

DOI: https://doi.org/10.1093/cid/ciaa449

SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells

Jingfang Mu, Jiuyue Xu, Leike Zhang, Ting Shu, Di Wu, Muhan Huang, Yujie Ren, Xufang Li, Qing Geng, Yi Xu, Yang Qiu & Xi Zhou 

Sci China Life Sci.

DOI: https://doi.org/10.1007/s11427-020-1692-1

Structure of M ^pro from COVID-19 virus and discovery of its inhibitors

Zhenming Jin, Xiaoyu Du, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Leike Zhang, Chao Peng, Yinkai Duan, Jing Yu, Lin Wang, Kailin Yang, Fengjiang Liu, Rendi Jiang, Xinglou Yang, Tian You, Xiaoce Liu, Xiuna Yang, Fang Bai, Hong Liu, Xiang Liu, Luke W. Guddat, Wenqing Xu, Gengfu Xiao, Chengfeng Qin, Zhengli Shi, Hualiang Jiang, Zihe Rao & Haitao Yang

Nature

Published: 9 April 2020

DOI: https://doi.org/10.1038/s41586-020-2223-y

Rapid and visual detection of 2019 novel coronavirus (SARS-CoV-2) by a reverse transcription loop-mediated isothermal amplification assay

C. Yan, J. Cui, L. Huang, B. Du, L. Chen, G. Xue, S. Li, W. Zhang, L. Zhao, Y. Sun, H. Yao, N. Li, H. Zhao, Y. Feng, S. Liu, Q. Zhang, D. Liu, J. Yuan

Clin Microbiol Infect.

Published: 7 April 2020

DOI: https://doi.org/10.1016/j.cmi.2020.04.001

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

Kai Duan, Bende Liu, Cesheng Li, Huajun Zhang, Ting Yu, Jieming Qu, Min Zhou, Li Chen, Shengli Meng, Yong Hu, Cheng Peng, Mingchao Yuan, Jinyan Huang, Zejun Wang, Jianhong Yu, Xiaoxiao Gao, Dan Wang, Xiaoqi Yu, Li Li, Jiayou Zhang, Xiao Wu, Bei Li, Yanping Xu, Wei Chen, Yan Peng, Yeqin Hu, Lianzhen Lin, Xuefei Liu, Shihe Huang, Zhijun Zhou, Lianghao Zhang, Yue Wang, Zhi Zhang, Kun Deng, Zhiwu Xia, Qin Gong, Wei Zhang, Xiaobei Zheng, Ying Liu, Huichuan Yang, Dongbo Zhou, Ding Yu, Jifeng Hou, Zhengli Shi, Saijuan Chen, Zhu Chen, Xinxin Zhang, and Xiaoming Yang

PNAS

Published: 6 April 2020

DOI: https://doi.org/10.1073/pnas.2004168117

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Shuai Xia, Meiqin Liu, Chao Wang, Wei Xu, Qiaoshuai Lan, Siliang Feng, Feifei Qi, Linlin Bao, Lanying Du, Shuwen Liu, Chuan Qin, Fei Sun, Zhengli Shi, Yun Zhu, Shibo Jiang, Lu Lu

Cell Research, 30(4):343-355

Published: 30 March 2020

DOI: https://doi.org/10.1038/s41422-020-0305-x

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

Jia Liu, Ruiyuan Cao, Mingyue Xu, Xi Wang, Huanyu Zhang, Hengrui Hu, Yufeng Li, Zhihong Hu, Wu Zhong & Manli Wang

Cell Discovery volume 6, Article number: 16 (2020)

Published: 18 March 2020

DOI: https://doi.org/10.1038/s41421-020-0156-0

A distinct name is needed for the new coronavirus

Shibo Jiang, Zhengli Shi, Yuelong Shu, Jingdong Song, George F Gao, Wenjie Tan and Deyin Guo

Lancet, 395(10228):949

Published: 19 Feburary 2020

DOI: https://doi.org/10.1016/S0140-6736(20)30419-0

Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes

Wei Zhang, Rong-Hui Du, Bei Li, Xiao-Shuang Zheng, Xing-Lou Yang, Ben Hu, Yan-Yi Wang, Geng-Fu Xiao, Bing Yan, Zheng-Li Shi & Peng Zhou

Emerg Microbes Infect., 9(1):386-389

Published: 17 Feburary 2020

DOI: https://doi.org/10.1080/22221751.2020.1729071

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

Xiaolong Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zhengli Shi, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu &Tianlei Ying

Emerg Microbes Infect., 9(1):382–385

Published: 17 Feburary 2020

DOI: https://doi.org/10.1080/22221751.2020.1729069

The first disease X is caused by a highly transmissible acute respiratory syndrome coronavirus

Shibo Jiang & Zheng-Li Shi 

Virol Sin.

Published: 14 Feburary 2020

DOI: https://doi.org/10.1007/s12250-020-00206-5

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

Shuai Xia, Yun Zhu, Meiqin Liu, Qiaoshuai Lan, Wei Xu, Yanling Wu, Tianlei Ying, Shuwen Liu, Zhengli Shi, Shibo Jiang & Lu Lu

Cell Mol Immunol.

Published: 11 Feburary 2020

DOI: https://doi.org/10.1038/s41423-020-0374-2

Clinical features and treatment of 2019-nCov pneumonia patients in Wuhan: report of a couple cases

Zhan Zhang, Xiaochen Li, Wei Zhang, Zheng-Li Shi, Zhishui Zheng & Tao Wang 

Virol Sin.

Published: 7 Feburary 2020

DOI: https://doi.org/10.1007/s12250-020-00203-8

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro 

Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong & Gengfu Xiao

Cell Research volume 30, pages 269–271

Published: 04 February 2020

DOI: https://doi.org/10.1038/s41422-020-0282-0

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Chao-Lin Huang, Hui-Dong Chen, Jing Chen, Yun Luo, Hua Guo, Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Xu-Rui Shen, Xi Wang, Xiao-Shuang Zheng, Kai Zhao, Quan-Jiao Chen, Fei Deng, Lin-Lin Liu, Bing Yan, Fa-Xian Zhan, Yan-Yi Wang, Geng-Fu Xiao & Zheng-Li Shi

Nature volume 579, pages 270–273

Published: 03 February 2020

DOI: https://doi.org/10.1038/s41586-020-2012-7

An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies

Shibo Jiang, Lanying Du & Zhengli Shi

Emerg Microbes Infect., 9(1):275-277

Published: 31 January 2020

DOI: https://doi.org/10.1080/22221751.2020.1723441