SARS-CoV-2 spillover events

Zhou P, Shi ZL.

Science

Published: 8 January 2021

DOI: https://doi.org/10.1126/science.abf6097

Pathological features of COVID-19-associated liver injury-a preliminary proteomics report based on clinical samples

Leng L, Cao R, Ma J, Lv L, Li W, Zhu Y, Wu Z, Wang M, Zhou Y, Zhong W.

Signal Transduct Target Ther.

Published: 8 January 2021

DOI: https://doi.org/10.1038/s41392-020-00406-1

AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells

Wang S, Qiu Z, Hou Y, Deng X, Xu W, Zheng T, Wu P, Xie S, Bian W, Zhang C, Sun Z, Liu K, Shan C, Lin A, Jiang S, Xie Y, Zhou Q, Lu L, Huang J, Li X.

Cell Res.

Published: 8 January 2021 

DOI: https://doi.org/10.1038/s41422-020-00460-y

Developing multiplex ddPCR assays for SARS-CoV-2 detection based on probe mix and amplitude based multiplexing

Nyaruaba R, Li C, Mwaliko C, Mwau M, Odiwuor N, Muturi E, Muema C, Xiong J, Li J, Yu J, Wei H.

Expert Rev Mol Diagn.

Published: 30 December 2020

DOI: https://doi.org/10.1080/14737159.2021.1865807

Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension 

Zhang LK, Sun Y, Zeng H, Wang Q, Jiang X, Shang WJ, Wu Y, Li S, Zhang YL, Hao ZN, Chen H, Jin R, Liu W, Li H, Peng K, Xiao G.

Cell Discov.

Published: 22 December 2020

DOI: https://doi.org/10.1038/s41421-020-00235-0

Epidemiological, clinical and serological characteristics of children with coronavirus disease 2019 in Wuhan: a single-centered, retrospective study

Luo D, Xia Z, Li H, Tu D, Wang T, Zhang W, Peng L, Yi W, Zhang S, Shu J, Xu H, Li Y, Shi B, Huang C, Tang W, Xiao S, Shu X, Liu Y, Zhang Y, Guo S, Yu Z, Wang B, Gao Y, Hu Q, Wang H, Song X, Mei H, Zhou X, Zheng Z.

Virol Sin.

Published: 22 December 2020

DOI: https://doi.org/10.1007/s12250-020-00333-z.

Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection

Pei R, Feng J, Zhang Y, Sun H, Li L, Yang X, He J, Xiao S, Xiong J, Lin Y, Wen K, Zhou H, Chen J, Rong Z, Chen X.

Protein Cell.

Published: 12 December 2020

DOI: https://doi.org/10.1007/s13238-020-00811-w

Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture

Zhang YN, Zhang QY, Li XD, Xiong J, Xiao SQ, Wang Z, Zhang ZR, Deng CL, Yang XL, Wei HP, Yuan ZM, Ye HQ, Zhang B.

Emerg Microbes Infect.

Published: December 2020

DOI: https://doi.org/10.1080/22221751.2020.1772676

A serological survey of SARS-CoV-2 in cat in Wuhan

Zhang Q, Zhang H, Gao J, Huang K, Yang Y, Hui X, He X, Li C, Gong W, Zhang Y, Zhao Y, Peng C, Gao X, Chen H, Zou Z, Shi ZL, Jin M.

Emerg Microbes Infect.

Published: December 2020

DOI: https://doi.org/10.1080/22221751.2020.1817796

Low toxicity and high immunogenicity of an inactivated vaccine candidate against COVID-19 in different animal models

Wang ZJ, Zhang HJ, Lu J, Xu KW, Peng C, Guo J, Gao XX, Wan X, Wang WH, Shan C, Zhang SC, Wu J, Yang AN, Zhu Y, Xiao A, Zhang L, Fu L, Si HR, Cai Q, Yang XL, You L, Zhou YP, Liu J, Pang DQ, Jin WP, Zhang XY, Meng SL, Sun YX, Desselberger U, Wang JZ, Li XG, Duan K, Li CG, Xu M, Shi ZL, Yuan ZM, Yang XM, Shen S.

Emerg Microbes Infect.

Published: 26 November 2020

DOI: https://doi.org/10.1080/22221751.2020.1852059

Evaluation of saliva as an alternative diagnostic specimen source for SARS-CoV-2 detection by RT-dPCR

Sui Z, Zhang Y, Tu J, Xie J, Huang W, Peng T, Dong L, Yang J, Ouyang Y, Liu S, Li L, Wang Z, Peng K, Fang X, Dai X.

J Infect.

Published: 25 November 2020

DOI: https://doi.org/10.1016/j.jinf.2020.11.023

Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin

Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL.

Nature

Published: 17 November 2020

DOI: https://doi.org/10.1038/s41586-020-2951-z

Prolonged shedding of severe acute respiratory syndrome coronavirus 2 in patients with COVID-19

Li Q, Zheng XS, Shen XR, Si HR, Wang X, Wang Q, Li B, Zhang W, Zhu Y, Jiang RD, Zhao K, Wang H, Shi ZL, Zhang HL, Du RH, Zhou P.

Emerg Microbes Infect.

Published: 16 November 2020

DOI: https://doi.org/10.1080/22221751.2020.1852058

Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

Wang S, Peng Y, Wang R, Jiao S, Wang M, Huang W, Shan C, Jiang W, Li Z, Gu C, Chen B, Hu X, Yao Y, Min J, Zhang H, Chen Y, Gao G, Tang P, Li G, Wang A, Wang L, Zhang J, Chen S, Gui X, Yuan Z, Liu D.

Nat Commun.

Published: 13 November 2020

DOI: https://doi.org/10.1038/s41467-020-19568-1

Infection of human sweat glands by SARS-CoV-2

Jia Liu, Yufeng Li, Liang Liu, Xudong Hu, Xi Wang, Hengrui Hu, Zhihong Hu, Yiwu Zhou, Manli Wang

Cell Discovery

Published: 13 November 2020

DOI: https://doi.org/10.1038/s41421-020-00229-y

Baicalein inhibits SARS-CoV-2/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner

Shichao Huang, Yu’e Liu, Yanan Zhang, Ru Zhang, ChengJie Zhu, Lihong Fan, Gang Pei, Bo Zhang, Yufeng Shi

Signal Transduction and Targeted Therapy

Published: 13 November 2020

DOI: https://www.nature.com/articles/s41392-020-00353-x

High-throughput screening of an FDA-approved drug library identifies inhibitors against arenaviruses and SARS-CoV-2

Wan W, Zhu S, Li S, Shang W, Zhang R, Li H, Liu W, Xiao G, Peng K, Zhang L.

ACS Infect Dis.

Published: 12 November 2020

DOI: https://doi.org/10.1021/acsinfecdis.0c00486

Immune responses and residual SARS-CoV-2 in two critically ill COVID-19 patients before and after lung transplantation

Yan Y, Jiang X, Fu J, Huang J, Qiu Y, Ding D, Ge L, Zhang H, Huang L, Lu X, Hu Q.

J Infect.

Published: 12 November 2020

DOI: https://doi.org/10.1016/j.jinf.2020.11.006

Detectable serum severe acute respiratory syndrome coronavirus 2 viral load (RNAemia) is closely correlated with drastically elevated interleukin 6 level in critically Ill patients with coronavirus disease 2019

Chen X, Zhao B, Qu Y, Chen Y, Xiong J, Feng Y, Men D, Huang Q, Liu Y, Yang B, Ding J, Li F.

Clin Infect Dis.

Published: 5 November 2020

DOI: https://doi.org/10.1093/cid/ciaa449

Identification of SARS-CoV-2 entry inhibitors among already approved drugs

Li Yang, Rong-juan Pei, Heng Li, Xin-na Ma, Yu Zhou, Feng-hua Zhu, Pei-lan He, Wei Tang, Ye-cheng Zhang, Jin Xiong, Shu-qi Xiao, Xian-kun Tong, Bo Zhang, Jian-ping Zuo

Acta Pharmacol Sin.

Published: 28 October 2020

DOI: https://doi.org/10.1038/s41401-020-00556-6

SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response

Yu-Zhi Fu, Su-Yun Wang, Zhou-Qin Zheng, Yi Huang, Wei-Wei Li, Zhi-Sheng Xu, Yan-Yi Wang

Cell Mol Immunol.

Published: 27 October 2020

DOI: https://doi.org/10.1038/s41423-020-00571-x

Plasma proteomics identify biomarkers and pathogenesis of COVID-19

Ting Shu, Wanshan Ning, Di Wu, Jiqian Xu, Qiangqiang Han, Muhan Huang, Xiaojing Zou, Qingyu Yang, Yang Yuan, Yuanyuan Bie, Shangwen Pan, Jingfang Mu, Yang Han, Xiaobo Yang, Hong Zhou, Ruiting Li, Yujie Ren, Xi Chen, Shanglong Yao, Yang Qiu, Ding-Yu Zhang, Yu Xue, You Shang, Xi Zhou

Immunity

Published: 20 October 2020

DOI: https://doi.org/10.1016/j.immuni.2020.10.008

Characteristics of SARS-CoV-2 and COVID-19

Hu B, Guo H, Zhou P, Shi ZL

Nat Rev Microbiol.

Published: 6 October 2020

DOI: https://doi.org/10.1038/s41579-020-00459-7

Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein

Yang C, Pan X, Xu X, Cheng C, Huang Y, Li L, Jiang S, Xu W, Xiao G, Liu S

Signal Transduct Target Ther.

Published: 6 October 2020

DOI: https://doi.org/10.1038/s41392-020-00325-1

A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2

Zhe-Rui Zhang, Ya-Nan Zhang, Xiao-Dan Li, Hong-Qing Zhang, Shu-Qi Xiao, Fei Deng, Zhi-Ming Yuan, Han-Qing Ye & Bo Zhang

Signal Transduction and Targeted Therapy 

Published: 03 October 2020

DOI: https://doi.org/10.1038/s41392-020-00343-z

Analysis of the clinical characteristics of 77 COVID-19 deaths

Wang K, Qiu Z, Liu J, Fan T, Liu C, Tian P, Wang Y, Ni Z, Zhang S, Luo J, Liu D, Li W

Sci Rep.

Published: 2 October 2020

DOI: https://doi.org/10.1038/s41598-020-73136-7

Distribution of airborne SARS-CoV-2 and possible aerosol transmission in Wuhan hospitals, China

Jia Hu,  Chengfeng Lei,  Zhen Chen,  Weihua Liu,  Xujuan Hu,  Rongjuan Pei, Zhengyuan Su,  Fei Deng,  Yu Huang,  Xiulian Sun,  Junji Cao, Wuxiang Guan

National Science Review

Published: 28 September 2020

DOI: https://doi.org/10.1093/nsr/nwaa250

Temporal antibody responses to SARS-CoV-2 in patients of coronavirus disease 2019

Min Huang, Qing-Bin Lu, Han Zhao, Yulan Zhang, Zhiwei Sui, Liqun Fang, Di Liu, Xiulian Sun, Ke Peng, Wei Liu, Wuxiang Guan

Cell Discov.

Published: 15 September 2020

DOI: https://doi.org/10.1038/s41421-020-00209-2

SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2

Jingfang Mu, Yaohui Fang, Qi Yang, Ting Shu, An Wang, Muhan Huang, Liang Jin, Fei Deng, Yang Qiu, Xi Zhou

Cell Discov.

Published: 15 September 2020

DOI: https://doi.org/10.1038/s41421-020-00208-3

Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication

Zhen Zhou, Yu Zhou, Xia-Ming Jiang, Yanbo Wang, Xi Chen, Gengfu Xiao, Chen-Yu Zhang, Yongxiang Yi, Lei-Ke Zhang, Liang Li

Cell Discov. 

Published: 11 September 2020

DOI: https://doi.org/10.1038/s41421-020-00206-5

Comparative antiviral efficacy of viral protease inhibitors against the novel SARS-CoV-2 in vitro

Leike Zhang, Jia Liu, Ruiyuan Cao, Mingyue Xu, Yan Wu, Weijuan Shang, Xi Wang, Huanyu Zhang, Xiaming Jiang, Yuan Sun, Hengrui Hu, Yufeng Li, Gang Zou, Min Zhang, Lei Zhao, Wei Li, Xiaojia Guo, Xiaomei Zhuang, Xing-Lou Yang, Zheng-Li Shi, Fei Deng, Zhihong Hu, Gengfu Xiao, Manli Wang, Wu Zhong

Virol Sin.

Published: 10 September 2020

DOI: https://doi.org/10.1007/s12250-020-00288-1

A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles

Ya-Nan Zhang, Xiao-Dan Li, Zhe-Rui Zhang, Hong-Qing Zhang, Na Li, Jing Liu, Jia-Qi Li, Hua-Jun Zhang, Ze-Jun Wang, Shuo Shen, Zheng-Li Shi, Hong-Ping Wei, Zhi-Ming Yuan, Han-Qing Ye & Bo Zhang

Cell Res.

Published: 25 August 2020

DOI: https://doi.org/10.1038/s41422-020-00405-5

Characterizing COVID-19 severity, epidemiology and SARS-CoV-2 genotypes in a regional business hub of China

Yan Yan, Bin Liu, Hui Ding, Xu Wang, Yaping Dai, Difei Ding, Hui Yu, Mingchao Sha, Chunyan Lui, Davgadorj Chantsalmaa, Yuanwang Qiu, Lihua Huang, Qinxue Hu

J Infect.

Published: 25 August 2020

DOI: https://doi.org/10.1016/j.jinf.2020.08.031

Longitudinal characteristics of T cell responses in asymptomatic SARS-CoV-2 infection

Jingyi Yang, Ejuan Zhang, Maohua Zhong, Qingyu Yang, Ke Hong, Ting Shu, Dihan Zhou, Jie Xiang, Jianbo Xia, Xi Zhou, Dingyu Zhang, Chaolin Huang, You Shang, Huimin Yan

Virol Sin.

Published: 21 August 2020

DOI: https://doi.org/10.1007/s12250-020-00277-4

An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques

Liqiang Feng, Qian Wang, Chao Shan, Chenchen Yang, Ying Feng, Jia Wu, Xiaolin Liu, Yiwu Zhou, Rendi Jiang, Peiyu Hu, Xinglong Liu, Fan Zhang, Pingchao Li, Xuefeng Niu, Yichu Liu, Xuehua Zheng, Jia Luo, Jing Sun, Yingying Gu, Bo Liu, Yongcun Xu, Chufang Li, Weiqi Pan, Jincun Zhao, Changwen Ke, Xinwen Chen, Tao Xu, Nanshan Zhong, Suhua Guan, Zhiming Yuan, Ling Chen

Nat Commun.

Published: 21 August 2020

DOI: https://doi.org/10.1038/s41467-020-18077-5

Anti-SARS-CoV-2 potential of artemisinins in vitro

Ruiyuan Cao, Hengrui Hu, Yufeng Li, Xi Wang, Mingyue Xu, Jia Liu, Huanyu Zhang, Yunzheng Yan, Lei Zhao, Wei Li, Tianhong Zhang, Dian Xiao, Xiaojia Guo, Yuexiang Li, Jingjing Yang, Zhihong Hu, Manli Wang, Wu Zhong

ACS Infect Dis.

Published: 18 August 2020

DOI: https://doi.org/10.1021/acsinfecdis.0c00522

Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes: interim analysis of 2 randomized clinical trials

Shengli Xia, Kai Duan, Yuntao Zhang, Dongyang Zhao, Huajun Zhang, Zhiqiang Xie, Xinguo Li, Cheng Peng , Yanbo Zhang, Wei Zhang, Yunkai Yang, Wei Chen, Xiaoxiao Gao, Wangyang You, Xuewei Wang, Zejun Wang, Zhengli Shi, Yanxia Wang, Xuqin Yang, Lianghao Zhang, Lili Huang, Qian Wang, Jia Lu, Yongli Yang, Jing Guo, Wei Zhou, Xin Wan, Cong Wu, Wenhui Wang, Shihe Huang, Jianhui Du, Ziyan Meng, An Pan, Zhiming Yuan, Shuo Shen, Wanshen Guo, Xiaoming Yang

JAMA.

Published: 13 August 2020

DOI: https://doi.org/10.1001/jama.2020.15543

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

Rui Xiong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang, Yongliang Zhao, Yan Wu, Weijuan Shang, Xiaming Jiang, Jiwei Shan, Zihao Shen, Yi Tong, Liuxin Xu, Yu Chen, Yingle Liu, Gang Zou, Dimitri Lavillete, Zhenjiang Zhao, Rui Wang, Lili Zhu, Gengfu Xiao, Ke Lan, Honglin Li, Ke Xu

Protein Cell

Published: 4 August 2020

DOI: https://doi.org/10.1007/s13238-020-00768-w

Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients

Li-Kun Zhou, Zhen Zhou, Xia-Ming Jiang, Yishan Zheng, Xi Chen, Zheng Fu, Gengfu Xiao, Chen-Yu Zhang, Lei-Ke Zhang, Yongxiang Yi

Cell Discov.

Published: 2 August 2020

DOI: https://doi.org/10.1038/s41421-020-00197-3

Dynamic changes of antibodies to SARS-CoV-2 in COVID-19 patients at early stage of outbreak

Huaqing Shu, Shuzhen Wang, Shunan Ruan, Yaxin Wang, Jiancheng Zhang, Yin Yuan, Hong Liu, Yongran Wu, Ruiting Li, Shangwen Pan, Yaqi Ouyang, Shiying Yuan, Peng Zhou, You Shang

Virol Sin.

Published: 27 July 2020

DOI: https://doi.org/10.1007/s12250-020-00268-5

Immunological detection of serum antibodies in pediatric medical workers exposed to varying levels of SARS-CoV-2

Danna Tu, Junhua Shu, Xiaoli Wu, Heng Li, Zhi Xia, Yanfang Zhang, Yaohui Fang, Shu Shen, Wuxiang Guan, Hualin Wang, Zhaoxuan Huang, Guirong Wang, Xiaoqin Zhou, Fei Deng

J Infect.

Published: 25 July 2020

DOI: https://doi.org/10.1016/j.jinf.2020.07.023

Immunoglobulin fragment F(ab’)₂ against RBD potently neutralizes SARS-CoV-2 in vitro

Xiaoyan Pan, Pengfei Zhou, Tiejiong Fan, Yan Wu, Jing Zhang, Xiaoyue Shi, Weijuan Shang, Lijuan Fang, Xiaming Jiang, Jian Shi, Yuan Sun, Shaojuan Zhao, Rui Gong, Ze Chen, Gengfu Xiao 

Antiviral Research

Published: 10 July 2020

DOI: https://doi.org/10.1016/j.antiviral.2020.104868

Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques

Chao Shan, Yan-Feng Yao, Xing-Lou Yang, Yi-Wu Zhou, Ge Gao, Yun Peng, Lian Yang, Xue Hu, Jin Xiong, Ren-Di Jiang, Hua-Jun Zhang, Xiao-Xiao Gao, Cheng Peng, Juan Min, Ying Chen, Hao-Rui Si, Jia Wu, Peng Zhou, Yan-Yi Wang, Hong-Ping Wei, Wei Pang, Zheng-Fei Hu, Long-Bao Lv, Yong-Tang Zheng, Zheng-Li Shi, Zhi-Ming Yuan

Cell Res.

Published: 7 July 2020

DOI: https://doi.org/10.1038/s41422-020-0364-z

COVID-19: clinical aspects and therapeutics responses

Suliman Khan, Ashaq Ali, Hongwei Shi, Rabeea Siddique, Shabana, Ghulam Nabi, Junjie Hu, Tiejun Wang, Men Dong, Wajid Zaman, Guang Han

Saudi Pharm J.

Published: 3 July 2020

DOI: https://doi.org/10.1016/j.jsps.2020.06.022

SARS-CoV-2 does not replicate in aedes mosquito cells nor present in field-caught mosquitoes from Wuhan

Han Xia, Evans Atoni, Lu Zhao, Nanjie Ren, Doudou Huang, Rongjuan Pei, Zhen Chen, Jin Xiong, Raphael Nyaruaba, Shuqi Xiao, Bo Zhang, Zhiming Yuan

Virol Sin.

Published: 29 June 2020

DOI: https://doi.org/10.1007/s12250-020-00251-0

Nanopore targeted sequencing for the accurate and comprehensive detection of SARS-CoV-2 and other respiratory viruses

Ming Wang, Aisi Fu, Ben Hu, Yongqing Tong, Ran Liu, Zhen Liu, Jiashuang Gu, Bin Xiang, Jianghao Liu, Wen Jiang, Gaigai Shen, Wanxu Zhao, Dong Men, Zixin Deng, Lilei Yu, Wu Wei, Yan Li, Tiangang Liu

Small

Published: 24 June 2020

DOI: https://doi.org/10.1002/smll.202002169

Severe acute respiratory syndrome coronavirus 2-specific antibodies in pets in Wuhan, China

Jianjun Chen, Chaolin Huang, Yanan Zhang, Sai Zhang, Meilin Jin

J Infect.                                   

Published: 21 June 2020

DOI: https://doi.org/10.1016/j.jinf.2020.06.045

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

Chaofu Wang, Jing Xie, Lei Zhao, Xiaochun Fei, Heng Zhang, Yun Tan, Xiu Nie, Luting Zhou, Zhenhua Liu, Yong Ren, Ling Yuan, Yu Zhang, Jinsheng Zhang, Liwei Liang, Xinwei Chen, Xin Liu, Peng Wang, Xiao Han, Xiangqin Weng, Ying Chen, Ting Yu, Xinxin Zhang, Jun Cai, Rong Chen, Zheng-Li Shi, Xiu-Wu Bian

EBioMedicine.

Published: 20 June 2020; 57:102833.

DOI: https://doi.org/10.1016/j.ebiom.2020.102833

Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients

Zhi-Sheng Xu, Ting Shu, Liang Kang, Di Wu, Xing Zhou, Bo-Wei Liao, Xiu-Lian Sun, Xi Zhou, Yan-Yi Wang

Signal Transduct Target Ther.

Published: 19 June 2020; 5(1):100.

DOI: https://doi.org/10.1038/s41392-020-0211-1

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

Yujie Ren, Ting Shu, Di Wu, Jingfang Mu, Chong Wang, Muhan Huang, Yang Han, Xue-Yi Zhang, Wei Zhou, Yang Qiu, Xi Zhou

Cell Mol Immunol.

Published: 18 June 2020

DOI: https://doi.org/10.1038/s41423-020-0485-9

Analysis of 2019 novel coronavirus infection and clinical characteristics of outpatients: An epidemiological study from a fever clinic in Wuhan, China

Yanqiu Wei, Yanjun Lu, Liming Xia, Xianglin Yuan, Gang Li, Xinying Li, Li Liu, Wenhua Liu, Peng Zhou, Cong‐Yi Wang, Huilan Zhang

J Med Virol.

Published: 16 June 2020

DOI: https://doi.org/10.1002/jmv.26175

SARS-Coronavirus-2 Nsp13 possesses NTPase and RNA helicase activities that can be inhibited by bismuth salts

Ting Shu, Muhan Huang, Di Wu, Yujie Ren, Xueyi Zhang, Yang Han, Jingfang Mu, Ruibing Wang, Yang Qiu, Ding-Yu Zhang, Xi Zhou

Virol Sin.

Published: 4 June 2020

DOI: https://doi.org/10.1007/s12250-020-00242-1

Co-infection of SARS-CoV-2 and influenza virus in early stage of the COVID-19 epidemic in Wuhan, China

Xin Zheng, Hua Wang, Zhengyuan Su, Wei Li, Dongliang Yang, Fei Deng, Jianjun Chen 

J Infect.

Published: 28 May 2020; S0163-4453(20)30319-4

DOI: https://doi.org/10.1016/j.jinf.2020.05.041

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

Rui Shi, Chao Shan, Xiaomin Duan, Zhihai Chen, Peipei Liu, Jinwen Song, Tao Song, Xiaoshan Bi, Chao Han, Lianao Wu, Ge Gao, Xue Hu, Yanan Zhang, Zhou Tong, Weijin Huang, William Jun Liu, Guizhen Wu, Bo Zhang, Lan Wang, Jianxun Qi, Hui Feng, Fu-Sheng Wang, Qihui Wang, George Fu Gao, Zhiming Yuan & Jinghua Yan

Nature

Published: 26 May 2020

DOI: https://doi.org/10.1038/s41586-020-2381-y

Structural basis for RNA replication by the SARS-CoV-2 polymerase

Quan Wang, Jiqin Wu, Haofeng Wang, Yan Gao, Qiaojie Liu, An Mu, Wenxin Ji, Liming Yan, Yan Zhu, Chen Zhu, Xiang Fang, Xiaobao Yang, Yucen Huang, Hailong Gao, Fengjiang Liu, Ji Ge, Qianqian Sun, Xiuna Yang, Wenqing Xu, Zhijie Liu, Haitao Yang, Zhiyong Lou, Biao Jiang, Luke W. Guddat, Peng Gong, Zihe Rao

Cell

Published: 22 May 2020

DOI:https://doi.org/10.1016/j.cell.2020.05.034

Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2

Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Chao Shan, Yi-Wu Zhou, Xu-Rui Shen, Qian Li, Lei Zhang, Yan Zhu, Hao-Rui Si, Qi Wang, Juan Min, Xi Wang, Wei Zhang, Bei Li, Hua-Jun Zhang, Ralph S. Baric, Peng Zhou, Xing-Lou Yang, Zheng-Li Shi

Cell

Published: 21 May 2020

DOI: https://doi.org/10.1016/j.cell.2020.05.027

Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture

Ya-Nan Zhang, Qiu-Yan Zhang, Xiao-Dan Li, Jin Xiong, Shu-Qi Xiao, Zhen Wang, Zhe-Rui Zhang, Cheng-Lin Deng, Xing-Lou Yang, Hong-Ping Wei, Zhi-Ming Yuan, Han-Qing Ye & Bo Zhang

Emerging Microbes & Infections

Published: 20 May 2020

DOI: https://doi.org/10.1080/22221751.2020.1772676

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

Chunyan Yi, Xiaoyu Sun, Jing Ye, Longfei Ding, Meiqin Liu, Zhuo Yang, Xiao Lu, Yaguang Zhang, Liyang Ma, Wangpeng Gu, Aidong Qu, Jianqing Xu, Zhengli Shi, Zhiyang Ling, Bing Sun

Cell Mol Immunol.

Published: 15 May 2020

DOI: https://doi.org/10.1038/s41423-020-0458-z

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

Zhenming Jin, Yao Zhao, Yuan Sun, Bing Zhang, Haofeng Wang, Yan Wu, Yan Zhu, Chen Zhu, Tianyu Hu, Xiaoyu Du, Yinkai Duan, Jing Yu, Xiaobao Yang, Xiuna Yang, Kailin Yang, Xiang Liu, Luke W Guddat, Gengfu Xiao, Leike Zhang, Haitao Yang, Zihe Rao

Nat Struct Mol Biol.

Published: 07 May 2020

DOI: https://doi.org/10.1038/s41594-020-0440-6

The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro

Xi Wang, Ruiyuan Cao, Huanyu Zhang, Jia Liu, Mingyue Xu, Hengrui Hu, Yufeng Li, Lei Zhao, Wei Li, Xiulian Sun, Xinglou Yang, Zhengli Shi, Fei Deng, Zhihong Hu, Wu Zhong & Manli Wang

Cell Discov.

Published: 02 May 2020

DOI: https://doi.org/10.1038/s41421-020-0169-8

The importance of naturally attenuated SARS-CoV-2 in the fight against COVID-19

Jean Armengaud, Agnès Delaunay-Moisan, Jean-Yves Thuret, Eelco van Anken, Diego Acosta-Alvear, Tomás Aragón, Carolina Arias, Marc Blondel, Ineke Braakman, Jean-Francois Collet, René Courcol, Antoine Danchin, Jean-Francois Deleuze, Jean-Philippe Lavigne, Sophie Lucas, Thomas Michiels, Edward R B Moore, Jonathon Nixon-Abell , Ramon Rossello-Mora , Zheng-Li Shi, Antonio G Siccardi, Roberto Sitia, Daniel Tillett, Kenneth N Timmis, Michel B Toledano, Peter van der Sluijs, Elisa Vicenzi

Environ Microbiol.

Published: 28 April 2020

DOI: https://doi.org/10.1111/1462-2920.15039

Plasma metabolomic and lipidomic alterations associated with COVID-19

Di Wu, Ting Shu, Xiaobo Yang, Jian-Xin Song, Mingliang Zhang, Chengye Yao, Wen Liu, Muhan Huang, Yuan Yu, Qingyu Yang, Tingju Zhu, Jiqian Xu, Jingfang Mu, Yaxin Wang, Hong Wang, Tang Tang, Yujie Ren, Yongran Wu, Shu-Hai Lin, Yang Qiu, Ding-Yu Zhang, You Shang, Xi Zhou

National Science Review

Published: 28 April 2020

DOI: https://doi.org/10.1093/nsr/nwaa086

SARS-CoV-2 infection in children 

Xiaoxia Lu, Liqiong Zhang, Hui Du, Jingjing Zhang, Yuan Y Li, Jingyu Qu, Wenxin Zhang, Youjie Wang, Shuangshuang Bao, Ying Li, Chuansha Wu, Hongxiu Liu, Di Liu, Jianbo Shao, Xuehua Peng, Yonghong Yang, Zhisheng Liu, Yun Xiang, Furong Zhang, Rona M Silva, Kent E Pinkerton, Kunling Shen, Han Xiao, Shunqing Xu, Gary W K Wong, Chinese Pediatric Novel Coronavirus Study Team

N Engl J Med.

Published: 23 April 2020

DOI: https://doi.org/10.1056/NEJMc2005073

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Wenhao Dai, Bing Zhang, Xia-Ming Jiang, Haixia Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu, Chunpu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, Xiaobo Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Gengfu Xiao, Hualiang Jiang, Zihe Rao, Lei-Ke Zhang, Yechun Xu, Haitao Yang, Hong Liu

Science

Published: 22 April 2020

DOI: https://doi.org/10.1126/science.abb4489

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

Xiaohua Chen, Binghong Zhao, Yueming Qu, Yurou Chen, Jie Xiong, Yong Feng, Dong Men, Qianchuan Huang, Ying Liu, Bo Yang, Jinya Ding, Feng Li

Clin Infect Dis.

Published: 17 April 2020

DOI: https://doi.org/10.1093/cid/ciaa449

SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells

Jingfang Mu, Jiuyue Xu, Leike Zhang, Ting Shu, Di Wu, Muhan Huang, Yujie Ren, Xufang Li, Qing Geng, Yi Xu, Yang Qiu & Xi Zhou 

Sci China Life Sci.

Published: 10 April 2020

DOI: https://doi.org/10.1007/s11427-020-1692-1

Structure of M ^pro from COVID-19 virus and discovery of its inhibitors

Zhenming Jin, Xiaoyu Du, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Leike Zhang, Chao Peng, Yinkai Duan, Jing Yu, Lin Wang, Kailin Yang, Fengjiang Liu, Rendi Jiang, Xinglou Yang, Tian You, Xiaoce Liu, Xiuna Yang, Fang Bai, Hong Liu, Xiang Liu, Luke W. Guddat, Wenqing Xu, Gengfu Xiao, Chengfeng Qin, Zhengli Shi, Hualiang Jiang, Zihe Rao & Haitao Yang

Nature

Published: 9 April 2020

DOI: https://doi.org/10.1038/s41586-020-2223-y

Rapid and visual detection of 2019 novel coronavirus (SARS-CoV-2) by a reverse transcription loop-mediated isothermal amplification assay

C. Yan, J. Cui, L. Huang, B. Du, L. Chen, G. Xue, S. Li, W. Zhang, L. Zhao, Y. Sun, H. Yao, N. Li, H. Zhao, Y. Feng, S. Liu, Q. Zhang, D. Liu, J. Yuan

Clin Microbiol Infect.

Published: 7 April 2020

DOI: https://doi.org/10.1016/j.cmi.2020.04.001

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

Kai Duan, Bende Liu, Cesheng Li, Huajun Zhang, Ting Yu, Jieming Qu, Min Zhou, Li Chen, Shengli Meng, Yong Hu, Cheng Peng, Mingchao Yuan, Jinyan Huang, Zejun Wang, Jianhong Yu, Xiaoxiao Gao, Dan Wang, Xiaoqi Yu, Li Li, Jiayou Zhang, Xiao Wu, Bei Li, Yanping Xu, Wei Chen, Yan Peng, Yeqin Hu, Lianzhen Lin, Xuefei Liu, Shihe Huang, Zhijun Zhou, Lianghao Zhang, Yue Wang, Zhi Zhang, Kun Deng, Zhiwu Xia, Qin Gong, Wei Zhang, Xiaobei Zheng, Ying Liu, Huichuan Yang, Dongbo Zhou, Ding Yu, Jifeng Hou, Zhengli Shi, Saijuan Chen, Zhu Chen, Xinxin Zhang, and Xiaoming Yang

PNAS

Published: 6 April 2020

DOI: https://doi.org/10.1073/pnas.2004168117

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Shuai Xia, Meiqin Liu, Chao Wang, Wei Xu, Qiaoshuai Lan, Siliang Feng, Feifei Qi, Linlin Bao, Lanying Du, Shuwen Liu, Chuan Qin, Fei Sun, Zhengli Shi, Yun Zhu, Shibo Jiang, Lu Lu

Cell Research

Published: 30 March 2020

DOI: https://doi.org/10.1038/s41422-020-0305-x

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

Jia Liu, Ruiyuan Cao, Mingyue Xu, Xi Wang, Huanyu Zhang, Hengrui Hu, Yufeng Li, Zhihong Hu, Wu Zhong & Manli Wang

Cell Discovery

Published: 18 March 2020

DOI: https://doi.org/10.1038/s41421-020-0156-0

Does SARS-CoV-2 has a longer incubation period than SARS and MERS?

Xuan Jiang, Simon Rayner, Min-Hua Luo

J Med Virol.

Published: 24 February 2020

DOI: https://doi.org/10.1002/jmv.25708

A distinct name is needed for the new coronavirus

Shibo Jiang, Zhengli Shi, Yuelong Shu, Jingdong Song, George F Gao, Wenjie Tan and Deyin Guo

Lancet

Published: 19 February 2020

DOI: https://doi.org/10.1016/S0140-6736(20)30419-0

Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes

Wei Zhang, Rong-Hui Du, Bei Li, Xiao-Shuang Zheng, Xing-Lou Yang, Ben Hu, Yan-Yi Wang, Geng-Fu Xiao, Bing Yan, Zheng-Li Shi & Peng Zhou

Emerg Microbes Infect.

Published: 17 February 2020

DOI: https://doi.org/10.1080/22221751.2020.1729071

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

Xiaolong Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zhengli Shi, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu &Tianlei Ying

Emerg Microbes Infect.

Published: 17 February 2020

DOI: https://doi.org/10.1080/22221751.2020.1729069

The first disease X is caused by a highly transmissible acute respiratory syndrome coronavirus

Shibo Jiang & Zheng-Li Shi 

Virol Sin.

Published: 14 February 2020

DOI: https://doi.org/10.1007/s12250-020-00206-5

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

Shuai Xia, Yun Zhu, Meiqin Liu, Qiaoshuai Lan, Wei Xu, Yanling Wu, Tianlei Ying, Shuwen Liu, Zhengli Shi, Shibo Jiang & Lu Lu

Cell Mol Immunol.

Published: 11 February 2020

DOI: https://doi.org/10.1038/s41423-020-0374-2

Clinical features and treatment of 2019-nCov pneumonia patients in Wuhan: report of a couple cases

Zhan Zhang, Xiaochen Li, Wei Zhang, Zheng-Li Shi, Zhishui Zheng & Tao Wang 

Virol Sin.

Published: 7 February 2020

DOI: https://doi.org/10.1007/s12250-020-00203-8

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro 

Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong & Gengfu Xiao

Cell Research

Published: 04 February 2020

DOI: https://doi.org/10.1038/s41422-020-0282-0

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Chao-Lin Huang, Hui-Dong Chen, Jing Chen, Yun Luo, Hua Guo, Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Xu-Rui Shen, Xi Wang, Xiao-Shuang Zheng, Kai Zhao, Quan-Jiao Chen, Fei Deng, Lin-Lin Liu, Bing Yan, Fa-Xian Zhan, Yan-Yi Wang, Geng-Fu Xiao & Zheng-Li Shi

Nature

Published: 03 February 2020

DOI: https://doi.org/10.1038/s41586-020-2012-7

An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies

Shibo Jiang, Lanying Du & Zhengli Shi

Emerg Microbes Infect.

Published: 31 January 2020

DOI: https://doi.org/10.1080/22221751.2020.1723441