Research Progress

[08-10-2014]An Authentic Mouse Model of Persistent Hepatitis C Virus Infection Becomes Available

Researchers from WIV and Institute of Biophysics, CAS, published a cover story on Cell Research, titled Persistent hepatitis C virus infections and hepatopathologicalmanifestations in immune-competent humanized mice, which reported the world's first immune-competent humanized mice that allow the natural infection of HCV.Almost 40 years ago, HCV was identified by researchers in NIH. There are ab...

[08-10-2014]New strategy for rapid drug susceptibility test

The research team led by Prof. Wei Hongping recently published three research papers in Journal of Clinical Microbiology on drug susceptibility tests using a new strategy named as gene-to-protein function (GPF) they proposed. “The most significant advantage of the GPF strategy is that it detects the drug susceptibility through the function of the proteins synthesized in vitro instead of the in...

[08-10-2014]Progress in molecular imaging

The research team led by Prof. Cui Zongqiang from Analytical Microbiology and Nano-biology Center in WIV, and Prof. Zhang Xian-En from IBP, recently developed novel far-red mNeptunebased bimolecular fluorescence complementation (BiFC) and trimolecular fluorescence complementation (TriFC) systems with excitation and emission above 600 nm in the ‘tissue optical window’ for imaging protein–prot...

[08-10-2014]Progress in antiviral peptide targeting Japanese encephalitis virus (JEV) entry

Recently, the research team led by Pro. Xiao Gengfu from WIV, CAS, has identified a 12-peptide P3 which inhibited Japanese encephalitis virus (JEV) infection of BHK-21 cells by interfering with viral attachment to host cells. A phage display peptide library was panned against E DIII of JEV envelope protein, which plays an important role in the interaction of viral particles with host cell recep...