In the past two years, the collaborative research teams led by Prof. Peng Gong and Prof. Bo Zhang have published three papers focusing on the regulation between the methyltranferase and polymerase modules of flavivirus NS5. Since the report of the first flavivirus NS5 methyltransferase crystal structure (EMBO J 2002), scientists have made tremendous efforts in getting a full-length structure al...
Recently, the research group led by Prof. Hualin Wang and Prof. Zhihong Hu from WIV has made important progress on viral immune evasion strategies, results of which have been published in Journal of Molecular Cell Biology (5-Yr impact factor: 8.953; Ning et al., 2014). Innate immune system is the first line of host defense against pathogen infections. Recent studies have suggested that mitochon...
Researchers from WIV and Institute of Biophysics, CAS, published a cover story on Cell Research, titled Persistent hepatitis C virus infections and hepatopathologicalmanifestations in immune-competent humanized mice, which reported the world's first immune-competent humanized mice that allow the natural infection of HCV.Almost 40 years ago, HCV was identified by researchers in NIH. There are ab...
The research team led by Prof. Wei Hongping recently published three research papers in Journal of Clinical Microbiology on drug susceptibility tests using a new strategy named as gene-to-protein function (GPF) they proposed. “The most significant advantage of the GPF strategy is that it detects the drug susceptibility through the function of the proteins synthesized in vitro instead of the in...
