The research team led by Prof. Cui Zongqiang from Analytical Microbiology and Nano-biology Center in WIV, and Prof. Zhang Xian-En from IBP, recently developed novel far-red mNeptunebased bimolecular fluorescence complementation (BiFC) and trimolecular fluorescence complementation (TriFC) systems with excitation and emission above 600 nm in the ‘tissue optical window’ for imaging protein–prot...
Recently, the research team led by Pro. Xiao Gengfu from WIV, CAS, has identified a 12-peptide P3 which inhibited Japanese encephalitis virus (JEV) infection of BHK-21 cells by interfering with viral attachment to host cells. A phage display peptide library was panned against E DIII of JEV envelope protein, which plays an important role in the interaction of viral particles with host cell recep...
Recently, a series of studies from Prof. Tang Hong's lab indicate that innate-like T lymphocytes play a pivotal role in the maintenance of homeostasis of innate inflammatory responses. In sterile inflammation such as acute cardiac inflammatory response to high blood pressure, vascular endothelial cells and fibroblasts derived IFN-γ is responsible for recruitment and activation of CD8+ T cell...
The research team led by Prof. Chen Xinwen from WIV recently made great progress in innate immune pathway regulation, identifying an alternatively spliced isoform of MITA lacking exon 7, termed MITA-related protein (MRP), the findings of which has been published in the internationally prestigious journal, namely, The Journal of Immunology. The team identified an alternatively spliced isoform of...
