Tuberculosis, an ancient, yet re-emerging infectious disease, is responsible for more deaths than almost all other infectious diseases, and the vaccine, drugs and diagnostic tests currently in use are limiting the effectiveness of global efforts to prevent and control TB. The BCG vaccine, the only licensed TB vaccine, has now been in use for almost one hundred years; however, it provides only l...
The self-assembly of nanoparticles into larger superstructures is a powerful strategy to develop novel functional nanomaterials, as these superstructures display collective properties that are different to those displayed by individual nanoparticles or bulk samples. However, there are increasing bottlenecks in terms of size control and multifunctionalization of nanoparticle assemblies.
Protein nanocages (PNCs) have been recognized as a promising platform for nanomedicine innovation. Real-time in vivo tracking of PNCs can provide critically important information for the development of PNC-based diagnostics and therapeutics.
On Dec 18, 2015, the research group led by Prof. Chaoyang Li in WIV, had reported the identification of another PDAC cell line, AsPC-1, which expresses a matured, GPI-anchoredPrP.Comparisonofthe24genes involved in the GPI anchor modification pathway between AsPC-1 and BxPC-3 revealed 15 of the 24 genes, including PGAP1 and PIG-F were down regulated in the latter cells. They also identified 6 mi...
