Research Progress

[15-12-2017]Natural insect virus baculovirus has evolved a distinct strategy to suppress the host immune system

Melanization is one of important modules in insect defense system. It consists of a cascade of clip-domain serine proteases (cSPs) that converts the zymogen prophenoloxidase (PPO) to active phenoloxidase (PO), which is negatively regulated by serpins. PO then catalyses the formation of melanin that physically encapsulates certain pathogens. Parasites and bacteria have evolved to produce specifi...

[14-12-2017]Chinese Researchers demonstrated that a virus can suppress the N-end rule pathway

The N-end rule pathway is a proteasome dependent proteolytic system that recognizes and degrades proteins containing N-degrons, and has emerged as a key regulator of various processes. Viruses manipulate diverse host pathways to facilitate viral replication and evade antiviral defenses. However, it remains unclear if viral infection has any impact on the N-end rule pathway.

[01-12-2017]Bats in China carry all the ingredients to make a new SARS virus

In that outbreak, masked palm civet cats sold in live animal markets passed the virus to people. It wasn’t clear whether civets were the initial source of the virus, or if they caught it from some other animal. Since then, evidence has been building implicating species of horseshoe bats as the origin (SN: 11/30/13, p. 13). Until now, though, coronaviruses isolated from bats were genetically di...

[24-11-2017]Chinese Researchers Reveal the Function of Prion Protein in Tumorigenesis

Prion protein (PrP) is a glycosylphosphatidylinositol anchored protein widely expressed in central nervous system, lymphoreticular system and GI tract. It has been attributed to neurodegenerative diseases such as prion disease and alzheimers disease. However, normal functions of PrP remains in-completely understood.