Research Progress

[05-11-2018]UATGs play an important role in the viral life cycle

Human bocavirus (HBoV) was first identified in 2005. HBoV1 infection leads to various clinical manifestations such as pneumonia, bronchiolitis and acute otitis media, which can be life-threatening. The capsid mRNA transcripts of HBoV1 can be generated by alternative splicing from the mRNA precursor transcribed from the P5 promoter. However, the detailed mechanism that regulates the alternative ...

[02-11-2018]Scientists demonstrated an explicit and unique mode of polymerase fidelity modulation

The intra-molecular NTD–RdRP interface and an open-conformation NS5B structure derived from the interface mutations.By solving 2.1–2.5 A resolution crystal structures of the classical swine fever virus (CSFV) NS5B, an RdRP with a unique naturally fused N-terminal domain (NTD), the research group led by Prof. GONG Peng in Wuhan Institute of Virology of the Chinese Academy of Sciences identifie...

[28-08-2018]Scientists found that ClyR could be a promising agent or additive for the prevention and treatmen...

Dental caries is a common disease caused by oral bacteria. Streptococcus mutans and Streptococcus sobrinus are the primary cariogenic microbes that often survive as biofilms on teeth. In a recent study, we the research group led by Prof. WEI Hongping in Wuhan Institute of Virology of the Chinese Academy of Sciences evaluated the activity of ClyR, a well-known chimeric lysin with extended strept...

[28-08-2018]A recombinant protein could attenuate S. aureus virulence and enhance host immune defenses via mu...

New anti‐infective approaches are much needed to control multi‐drug‐resistant (MDR) pathogens, such as methicillin‐resistant Staphylococcus aureus (MRSA). In a recent study, the research group led by Prof. WEI Hongping in Wuhan Institute of Virology of the Chinese Academy of Sciences found for the first time that a recombinant protein derived from the cell wall binding domain (CBD) of the b...