Research Progress

[02-05-2018]Scientists highlighted the oligomeric state as the functional form of GP41 in baculovrius replica...

In baculovirus, a large double stranded enveloped DNA virus, so far only a single protein, named GP41, has been identified as an O-glycosylated tegument protein. Baculoviruses are specific for insects and have been widely used as biocontrol agents of insect pests, as well as efficient gene expression and gene delivery vectors for human therapy. GP41 was originally identified as an O-linked glyc...

[08-04-2018]Bats Identified as Source of Pig-Killing Coronavirus in China

Researchers have identified a coronavirus that killed nearly 25,000 piglets in China in 2016 and 2017. Zheng-Li Shi, a virologist at the Wuhan Institute of Virology in China, and her colleagues report today (April 4) in Nature that the virus, named swine acute diarrhea syndrome coronavirus (SADS-CoV), emerged from horseshoe bats (Rhinolophidae). The same species of bats were the source of sever...

[13-03-2018]Search to prevent next human pandemic

To play good defense against the next viral pandemic, it helps to know the other team’s offense. But the 263 known viruses that circulate in humans represent less than 0.1 percent of the viruses suspected to be lurking out there that could infect people, researchers report in the Feb. 23 Science.

[09-03-2018]WDR5 represents interesting regulatory mechanism and a potential antiviral target

Human cytomegalovirus (HCMV) has a large (~235-kb) genome with over 170 ORFs and exploits numerous cellular factors to facilitate its replication. HCMV infection increases protein levels of WD repeat-containing protein 5 (WDR5) during infection, overexpression of WDR5 enhances viral replication, and knockdown of WDR5 dramatically attenuates viral replication. WDR5 is essential for assembling th...