Research Progress

[01-03-2018]How bats carry viruses without getting sick

Bats are known to harbor highly pathogenic viruses like Ebola, Marburg, Hendra, Nipah, and SARS-CoV, and yet they do not show clinical signs of disease. In a paper published in the journal Cell Host & Microbe on February 22, scientists at the Wuhan Institute of Virology in China find that in bats, an antiviral immune pathway called the STING-interferon pathway is dampened, and bats can maintain...

[01-03-2018]Chinese scientists develop new flu vaccine

A research group from Wuhan Institute of Virology, Chinese Academy of Sciences, announced that they have developed a new type of flu vaccine using nano-technology. The intranasal nano-vaccine can target broad-spectrum flu viruses and induces robust immune responses, said Cui Zongqiang, leader of the research group.

[19-12-2017]Scientists highlight the functional significance of NS3 in noroviral life cycle

Noroviruses are a genetically diverse group of non-enveloped, positive-stranded RNA viruses belonging to genus Norovirus of the family Caliciviridae. They arefurther segregated into seven genogroups (GI-GVII), three of which cause diseases exclusively in humans (GI, GII, and GIV). Human noroviruses (HuNoVs) are now considered the leading cause of viral gastroenteritis in humans across the globe...

[15-12-2017]Natural insect virus baculovirus has evolved a distinct strategy to suppress the host immune system

Melanization is one of important modules in insect defense system. It consists of a cascade of clip-domain serine proteases (cSPs) that converts the zymogen prophenoloxidase (PPO) to active phenoloxidase (PO), which is negatively regulated by serpins. PO then catalyses the formation of melanin that physically encapsulates certain pathogens. Parasites and bacteria have evolved to produce specifi...