Zika virus (ZIKV), as a re-emerging viral pathogen, belongs to the Flaviviridae family including dengue virus (DENV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and tick borne encephalitic virus (TBEV). It can be transmitted by Aedes mosquitoe and cause severe neurological diseases including Guillain-Barre Syndrome (GBS) in the adult, and congenital Zika...
In a recent study, a simple and efficient mitochondria‐docking (Mito‐docking) method for PPI detection in vivo is developed by the research team led by Prof. HU Zhihong and Dr. WANG Manli. The strategy is to anchor a “bait” protein to mitochondrial outer membrane (MOM), and then trap the “prey” protein onto MOM. In this way, interacting signals are enriched to allow easy detection. This m...
In a recent study, by cooperation with the research team led by Prof. ZHENG Xin from Tongji Medical College, Huazhong University of Science and Technology, the research groups led by Prof. WANG Hualin, Prof. HU Zhihong and Prof. DENG Fei from Wuhan Institute of Virology of the Chinese Academy of Sciences demonstrated that SFTSV infection results in substantial production of serum interferon-γ ...
In a recent study, the research group led by Prof. WANG Hualin in Wuhan institute of Virology of the Chinese Academy of Sciences demonstrated that HRTV infection can block both type I and III IFN antiviral signaling. Furthermore, the mechanism underlying HRTV manipulation of type I and III IFN signaling was unraveled by detailed comparative studies in the context of HRTV infection and transient...
