Research Progress

[16-07-2018]HCMV infection of NPCs results in the loss of the SOX2 protein

Congenital human cytomegalovirus (HCMV) infection is the leading cause of birth defects worldwide. Approximately 1% of live newborns are infected in utero with this virus. Recent advances in human neural progenitor cell (NPC) isolation and culture have provided an opportunity to study HCMV infection in a cell system relevant to fetal neuropathogenesis.

[04-07-2018]Researchers present a structure of RNA polymerase complex and genome within a dsRNA virus

Double-stranded RNA (dsRNA) viruses infect hosts ranging from fungi to plants and to humans. Like most other dsRNA viruses, the aquareovirus RNA polymerase catalyzes the synthesis of RNA plus strands within the inner capsid, a process vital for the replication of virus progeny.

[03-07-2018]Scientists suggest that doublecortin is modulated following infection of the brain by ZIKV

A Zika virus (ZIKV) outbreak has been ongoing in central and south America for the past 2 years, and has raised global concerns with regards to public health. ZIKV has been shown to infect neural progenitor cells (NPCs) and inhibits cell proliferation, growth of neurospheres and brain organoids, suggesting that the neuropathology induced by ZIKV might be associated with NPC cell fate. However, ...

[02-07-2018]ZIKV can be effectively attenuated by codon pair deoptimization

From June 2015, unprecedented epidemics of Zika virus (ZIKV) occur in the Americas, which cause the unexpected clinical symptoms including Guillain-Barre? syndrome, microcephaly and other birth defects in human. To date, there is no effective licensed vaccine or antiviral treatment against ZIKV infection, although several vaccine candidates have been described including formalin inactivated va...