Viruses with filamentous morphologies, such as tobacco mosaic virus (TMV) and M13 bacteriophage, have long been studied as multivalent nanoscaffolds for loading functional motifs. Structural assembly of the capsid proteins (CPs) of filamentous viruses often requires the presence of DNA or RNA molecules, which has limited their applications.
Congenital human cytomegalovirus (HCMV) infection is the leading cause of birth defects worldwide. Approximately 1% of live newborns are infected in utero with this virus. Recent advances in human neural progenitor cell (NPC) isolation and culture have provided an opportunity to study HCMV infection in a cell system relevant to fetal neuropathogenesis.
Double-stranded RNA (dsRNA) viruses infect hosts ranging from fungi to plants and to humans. Like most other dsRNA viruses, the aquareovirus RNA polymerase catalyzes the synthesis of RNA plus strands within the inner capsid, a process vital for the replication of virus progeny.
A Zika virus (ZIKV) outbreak has been ongoing in central and south America for the past 2 years, and has raised global concerns with regards to public health. ZIKV has been shown to infect neural progenitor cells (NPCs) and inhibits cell proliferation, growth of neurospheres and brain organoids, suggesting that the neuropathology induced by ZIKV might be associated with NPC cell fate. However, ...