Research Progress

[08-11-2017]Scientists generate a novel neutralizing mAb m27f whose epitope located in the pro-fusion domain ...

Herpes simplex virus (HSV) is a prevalent worldwide human pathogen that infects epithelial cells before it establishes latency in trigeminal or sacral nerve root ganglia, causing mucocutaneous lesions, keratitis, and encephalitis. The development of vaccines and novel therapeutic strategies against HSV has become very urgent.

[31-10-2017]Scientists provide direct evidence of the Emuc pathogenicity in vivo for the first time

Ebola virus (EBOV) is one of the most virulent pathogens to humans. Recently, the largest-ever outbreak of Ebola virus disease (EVD) in West Africa, 2013–2016, resulted in the unprecedented damage to human health and social economy. However, there is currently no licensed vaccine or antiviral available against EVD. Clinically, EBOV infection can result in exaggerated inflammatory responses and...

[25-09-2017]Scientists found that three conserved regions play important roles in the enzymatic activity and ...

Sulfhydryl oxidase catalyzes disulfide bond formation of substrate proteins. P33, a baculovirus-encoded sulfhydryl oxidase, is different from other cellular and viral sulfhydryl oxidases, bearing unique features in tertiary and quaternary structure organizations. To better understand the structural and functional relationship of P33, a series of point mutations in three conserved regions were g...

[21-09-2017]PrP plays critical roles in modulating inflammatory responses

Prion protein (PrP) is up-regulated in many cell types upon cellular activation or viral infection. However, the physiological consequences of PrP up-regulation remain incompletely understood. In a present study, the research group led by Prof. LI Chaoyang from Wuhan Institute of Virology of the Chinese Academy of Sciences found that when M2 cells were stimulated with TNFα, the TNFR signaling ...