Research Progress

[05-04-2017]A stable and safe tool to handle West Nile virus outside of a BSL-3 facility

West Nile virus (WNV), a mosquito-borne flavivirus, is an important neurotropic human pathogen. As a biosafety level-3 (BSL-3) agent, WNV is strictly to BSL-3 laboratories for experimentations, thus greatly hindering the development of vaccine and antiviral drug. Recently, the research group led by Prof. Bo Zhang in WIV, developed a novel pseudo-infectious WNV reporter virus expressing the Gaus...

[05-04-2017]A novel strategy for JEV to escape the host innate immune response is revealed

JEV is the major cause of viral encephalitis in South and Southeast Asia with high mortality. However, the molecular mechanisms contributing to the severe pathogenesis are poorly understood. The ability of JEV to counteract the host innate immune response may be one of the potential mechanisms responsible for JEV virulence.

[05-04-2017]Scientists reveal that M gene reassortment in H9N2 influenza virus promotes early infection and r...

Segment reassortment and base mutagenesis of influenza A viruses are the primary routes to the rapid evolution of high fitness virus genotypes.Scientists from China Agricultural University, University of Nottingham and Wuhan Institute of Virology recently described a predominant G57 genotype of avian H9N2 viruses that caused country-wide outbreaks in chickens in China during 2010-2013 which led...

[27-02-2017]Sub-ICs of anti-folates can potentiate bactericidal effects of other antimicrobial agents in vari...

Synergies between sulfonamides and other antimicrobial agents have long been reported, but the reason still remains unclear. Previously, Vilchèze et al. found that, sulfamethoxazole (SMX) could potentiate the bacterialcidal activity of isoniazid (INH) and rifampin (RIF) in Mycobacterium tuberculosis.