Research Progress

[29-10-2019]Scientists provide new insights into LASV GP-host interactions

In a recent study by the research group led by Prof. XIAO Gengfu in Wuhan Institute of Virology of the Chinese Academy of Sciences, a comprehensive LASV GP interactome was characterized, and further study revealed that STT3B-dependent N-glycosylation was preferentially required by arenavirus GPs and critical for virus infectivity.

[10-07-2019]Two immunogen candidates have potential utility for neutralizing antibody selection and vaccine d...

Zika virus (ZIKV), as a re-emerging viral pathogen, belongs to the Flaviviridae family including dengue virus (DENV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and tick borne encephalitic virus (TBEV). It can be transmitted by Aedes mosquitoe and cause severe neurological diseases including Guillain-Barre Syndrome (GBS) in the adult, and congenital Zika...

[05-07-2019]Mito-docking can be used as a novel method to detect protein-protein interactions in vivo

In a recent study, a simple and efficient mitochondria‐docking (Mito‐docking) method for PPI detection in vivo is developed by the research team led by Prof. HU Zhihong and Dr. WANG Manli. The strategy is to anchor a “bait” protein to mitochondrial outer membrane (MOM), and then trap the “prey” protein onto MOM. In this way, interacting signals are enriched to allow easy detection. This m...

[02-07-2019]Scientists provide new insights into IFN-γ antiviral biology and SFTSV pathogenesis

In a recent study, by cooperation with the research team led by Prof. ZHENG Xin from Tongji Medical College, Huazhong University of Science and Technology, the research groups led by Prof. WANG Hualin, Prof. HU Zhihong and Prof. DENG Fei from Wuhan Institute of Virology of the Chinese Academy of Sciences demonstrated that SFTSV infection results in substantial production of serum interferon-γ ...