Scientists from Wuhan Institute of Virology (WIV) of the Chinese Academy of Sciences, recently uncovered an interesting interplay of SFTSV infection with the signaling mediated by RIG-I, a critical cellular PRR localized in cytosol (Figure 1). They found that RIG-I plays a major role in the cellular recognition of SFTSV and the host immune/inflammatory responses to SFTSV infection, but in turn,...