Baculoviruses are rod-shaped, large dsDNA viruses that infect insects from the families Lepidoptera, Hymenoptera, and Diptera. Entry of baculovirus in host insects is mediated by a per os infectivity factor (PIF) complex on the envelope of occlusion-derived virus. The mechanism of PIF complex assembly is still largely unknown. Knowledge of the composition and structure of the PIF complex is fun...
During virus infection, uncoating is a key step to release the viral genome into host cells, and this step is an attractive antiviral target. However, virus uncoating, especially influenza A virus (IAV), which contains an unusual genome of eight segmented RNAs, has been a poorly understood process due to limitation in applicable methodology for detecting this transient and dynamic event.
Filoviruses, especially Ebola virus (EBOV) and Marburg virus (MARV), are notoriously pathogenic and capable of causing severe hemorrhagic fever diseases in humans with high lethality. The risk of future outbreaks of filoviruses is drawing increasing concern as other bat-borne filoviruses such as Lloviu virus and Bombali virus were globally discovered with great genetic diversity.
Fc-based therapeutic proteins include therapeutic antibodies and Fc-fusion proteins. Therapeutic monoclonal antibodies (mAbs) with high affinity and specificity are now widely used in treatment of cancer, immune disorders, viral infection and other diseases. Fc-fusion proteins are also emerging as promising biopharmaceuticals because of the additional benefits from Fc fragment.