The N-end rule pathway is a proteasome dependent proteolytic system that recognizes and degrades proteins containing N-degrons, and has emerged as a key regulator of various processes. Viruses manipulate diverse host pathways to facilitate viral replication and evade antiviral defenses. However, it remains unclear if viral infection has any impact on the N-end rule pathway.
In that outbreak, masked palm civet cats sold in live animal markets passed the virus to people. It wasn’t clear whether civets were the initial source of the virus, or if they caught it from some other animal. Since then, evidence has been building implicating species of horseshoe bats as the origin (SN: 11/30/13, p. 13). Until now, though, coronaviruses isolated from bats were genetically di...
Prion protein (PrP) is a glycosylphosphatidylinositol anchored protein widely expressed in central nervous system, lymphoreticular system and GI tract. It has been attributed to neurodegenerative diseases such as prion disease and alzheimers disease. However, normal functions of PrP remains in-completely understood.
Herpes simplex virus (HSV) is a prevalent worldwide human pathogen that infects epithelial cells before it establishes latency in trigeminal or sacral nerve root ganglia, causing mucocutaneous lesions, keratitis, and encephalitis. The development of vaccines and novel therapeutic strategies against HSV has become very urgent.