RNAi is an evolutionarily conserved post-transcriptional gene silencing mechanism in eukaryotes, and has been well recognized as an antiviral immunity in fungi, plants, and invertebrates. In the process of antiviral RNAi, viral dsRNA replicative intermediates generated during RNA virus replication are recognized and processed by Dicer into siRNAs. These virus-derived siRNAs (vsiRNAs) are then t...
Mineralization templated by bio-nanostructures has been a focus in the field of nanomaterial synthesis of late. Various bio-nanostructures (e.g., protein nanocages, nanotubes, and nanowires) have been investigated for the templated synthesis of nanomaterials and have been found to offer excellent control over the morphology and properties of the target.
Damage of brain connectome in neurodegenerative diseases remains unclear. Revealing the differences and abnormalities of neuronal circuits between healthy individuals and patients with PD or AD will contribute to understanding the mechanism(s) of these diseases. Mapping the brain connectome requires appropriate tracing tools, but the anterograde tracing tools are underdevelopment, and particula...
The neurological damage caused by varicella-zoster virus (VZV) reactivation is commonly manifested as clinical problems. Thus, identifying viral neurovirulent genes and characterizing their functions are important for relieving VZV related neurological complications. ORF7 has been previously identified as a potential neurotropic gene, but its involvement in VZV replication is unclear. In a join...
