Research Progress

[11-05-2017]Scientists find a negative regulator of innate antiviral immune responses

Recognition of conserved molecular structures of viruses by the host pattern-recognition receptors (PRRs) initiates innate antiviral immune responses. Several families of PRRs, including Toll-like receptors (TLRs), RIG-like receptors (RLRs), NOD-like receptors (NLRs) and recently identified DNA sensors, have been shown to sense different microbial components. Previously, the research group led ...

[04-05-2017]Scientists illustrate how host cell responds to Zika virus infection

Zika virus (ZIKV) is an emerging arthropod-born virus (arbovirus) belonging to the genus Flavivirus of the family Flaviviridae, which also includes a group of human pathogenic viruses such as dengue virus 1-4 (DENV 1-4), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and tick-borne encephalitis virus (TBEV). In early 2015, a ZIKV infection outbreak was recog...

[28-04-2017]Researchers reveal a complex pattern of the evolution and emergence of H5N6 avian influenza virus...

Since H5N6 avian influenza virus first emerged in China in 2013, it has caused more than ten human deaths in China, which poses potential risks to human health. In order to further understand the evolutionary behavior of H5N6 prior to its emergence in humans, the research group led by Prof. CUI Jie from Wuhan Institute of Virology of the Chinese Academy of Sciences developed the studies on the ...

[18-04-2017]Single-particle tracking reveals the mechanism for HIV-1 productive entry into primary macrophages

Macrophages are one of the major targets of human immunodeficiency virus (HIV-1), but how the virus enters the macrophages is still poorly understood. In present study, Prof. CUI Zongqiang from Wuhan Institute of Virology of the Chinese Academy of Sciences, Prof. ZHANG Xian’en from Institute of Biophysics of the Chinese Academy of Sciences, and Prof. WU Yuntao from George Mason University have...