Research Progress

[27-02-2017]A useful antibacterial to combat Methicillin-resistant Stanphylococcus aureus is represented

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening pathogens due to its multi-drug resistance (MDR) and strong biofilm-forming capacity. Prof. Hongping Wei and his research group from WIV described the screening of a novel chimeolysin (ClyF) that was active against planktonic and biofilm MRSA. Biochemical tests showed that ClyF was active against all S. aureus cli...

[27-02-2017]Scientists reveal that MITA/STING plays an important role in triggering HBV specific adaptive imm...

An efficient clearance of hepatitis B virus (HBV) requires the coordinated work of both the innate and adaptive immune responses. MITA/STING, an adapter protein of the innate immune signaling pathways, plays a key role in regulating innate and adaptive immune responses to DNA virus infection. Previously, the Research Group of Molecular Biology of Hepatitis Viruses and Gene Therapy led by Prof. ...

[25-12-2016]WIV finds Arp2/3 subcellular distribution is controlled by CRM1-dependent nuclear export under st...

Actin, nucleation-promoting factors (NPFs), and the actin-related protein 2/3 complex (Arp2/3) are key elements of the cellular actin polymerization machinery. With nuclear actin polymerization implicated in ever-expanding biological processes and the discovery of the nuclear import mechanisms of actin and NPFs, determining Arp2/3 nucleo-cytoplasmic shuttling mechanism is important for understa...

[25-12-2016]SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D to Facilitate Viral Replication

Accumulating evidences suggest that viruses hijack cellular proteins to circumvent the host immune system. Ubiquitination and SUMOylation are extensively studied post-translational modifications (PTMs) that play critical roles in diverse biological processes. Crosstalk between ubiquitination and SUMOylation of both host and viral proteins has been reported to result in distinct functional conse...