Research Progress

[13-04-2017]Scientists reveal the pathogenic mechanism of arthropod-borne flaviviruses by using in vivo biolu...

In present study, the research group led by Prof. ZHANG Bo from Wuhan Institute of Virology of the Chinese Academy of Sciences and the research team led by Prof. QIN Chengfeng from Institute of Microbiology and Epidemiology of the Academy of Military Medical Sciences made an important breakthrough in the pathogenic mechanism of arthropod-borne flaviviruses. By using in vivo bioluminescence imag...

[05-04-2017]The uncoupling of catalysis and translocation in the viral RNA-dependent RNA polymerase

The nucleotide addition cycle of nucleic acid polymerases includes two major events: the pre-chemistry active site closure leading to the addition of one nucleotide to the product chain; the post-chemistry translocation step moving the polymerase active site one position downstream on its template. In viral RNA-dependent RNA polymerases (RdRPs), structural and biochemical evidences suggest that...

[05-04-2017]A basis for the development of peptide-based drugs to prevent JEV and ZIKV infection

Japanese encephalitis virus (JEV) and Zika virus (ZIKV) are mosquito-borne viruses of the Flavivirus genus that cause viral encephalitis and congenital microcephaly, respectively, in humans, and thus present a risk to global public health. The envelope glycoprotein (E protein) of flaviviruses is a class II viral fusion protein that mediates host cell entry through a series of conformational cha...

[05-04-2017]Scientists find that deletion of nudB causes increased susceptibility to antifolates in Escherich...

Co-trimoxazole, a fixed-dose combination of sulfamethoxazole (SMX) and trimethoprim (TMP), has been used for the treatment of bacterial infections since the 1960s. Since it has long been assumed that the synergistic effects between SMX and TMP are the consequence of targeting 2 different enzymes of bacterial folate biosynthesis, 2 genes (pabB and nudB) involved in the folate biosynthesis of Esc...