The TLR5 agonist flagellin has been proven as an effective mucosal adjuvant, in addition to its systemic adjuvant activity, when administered via the i.n. route, which can prominently increase a protective IgA response. However, the mechanism by which flagellin drives a mucosal immune response when acting as an i.n. adjuvant remains elusive. In a present study, the research group led by Prof. Y...
Advances in synthetic biology have come to an age of whole genome synthesis. Synthetic viruses provide a powerful platform to delve deeper into the nature and function of viruses as well as to engineer viruses with novel properties. To date, most of synthesized viruses have been RNA viruses. RNA viruses normally have a limited genome size with the biggest reported so far are from coronaviruses ...
Single genomic loci in human chromosomes are often related to specific cellular functions, human genetic diseases and pathogen infections. Live visualization of single genomic loci would help to elucidate the spatiotemporal positions, dynamics and function of different loci and offer understanding of genome architecture and regulation. However, imaging of single genomic loci in live cells is cu...
Recognition of conserved molecular structures of viruses by the host pattern-recognition receptors (PRRs) initiates innate antiviral immune responses. Several families of PRRs, including Toll-like receptors (TLRs), RIG-like receptors (RLRs), NOD-like receptors (NLRs) and recently identified DNA sensors, have been shown to sense different microbial components. Previously, the research group led ...
