Research Progress

[02-06-2017]Scientists investigated the effect of ORF7 deletion on varicella-zoster virus replication cycle

The neurological damage caused by varicella-zoster virus (VZV) reactivation is commonly manifested as clinical problems. Thus, identifying viral neurovirulent genes and characterizing their functions are important for relieving VZV related neurological complications. ORF7 has been previously identified as a potential neurotropic gene, but its involvement in VZV replication is unclear. In a join...

[26-05-2017]Scientists confirmed that GM-CSF derived from NECs play an important role in TLR5-mediated DC act...

The TLR5 agonist flagellin has been proven as an effective mucosal adjuvant, in addition to its systemic adjuvant activity, when administered via the i.n. route, which can prominently increase a protective IgA response. However, the mechanism by which flagellin drives a mucosal immune response when acting as an i.n. adjuvant remains elusive. In a present study, the research group led by Prof. Y...

[25-05-2017]Scientists report on the first synthesis of a baculovirus

Advances in synthetic biology have come to an age of whole genome synthesis. Synthetic viruses provide a powerful platform to delve deeper into the nature and function of viruses as well as to engineer viruses with novel properties. To date, most of synthesized viruses have been RNA viruses. RNA viruses normally have a limited genome size with the biggest reported so far are from coronaviruses ...

[23-05-2017]Scientists map single-copy HIV-1 provirus loci in human chromosomes in live host cells

Single genomic loci in human chromosomes are often related to specific cellular functions, human genetic diseases and pathogen infections. Live visualization of single genomic loci would help to elucidate the spatiotemporal positions, dynamics and function of different loci and offer understanding of genome architecture and regulation. However, imaging of single genomic loci in live cells is cu...