Research Progress

[25-12-2016]WIV Researchers developed a three-fragment fluorescence complementation system

Many cellular processes are governed by molecular machineries that involve multiple protein interactions. However, visualizing and identifying multiprotein complexes such as ternary complexes inside cells is always challenging,particularly in the subdiffraction cellular space. The research group led by Prof. Zongqiang Cui in WIV developed a three-fragment fluorescence complementation system (TF...

[25-12-2016]WIV found the new mechanism that Arenaviridae affects the natural immune system

The Arenaviridae family includes several important human pathogens that can cause severe hemorrhagic fever and greatly threaten public health. As a major component of the innate immune system, the RLR/MAVS signaling pathway is involved in recognizing viral components and initiating antiviral activity. It has been reported that arenavirus infection can suppress the innate immune response, and ar...

[25-12-2016]Scientists in WIV reveal the asymmetric movement of the double-stranded RNA

RNA viruses encode a unique class of RNA-dependent RNA polymerases (RdRPs) to carry out their fully RNA-based genome replication and transcription. Although the chemical nature of nucleotide addition is essentially shared by all nucleic acid polymerases, the structural and mechanistic details taken by each polymerase class differ to various extents. The research group led by Prof. Peng Gong in ...

[25-12-2016]In Vivo Targeting and Imaging of Atherosclerosis Using Multifunctional Virus-Like Particles of Si...

Atherosclerosis is a leading cause of death globally. Targeted imaging and therapeutics are desirable for the detection and treatment of the disease. Recently, the research group led by Prof. Zongqiang Cui in WIV developed trifunctional Simian virus 40 (SV40)-based nanoparticles for in vivo targeting and imaging of atherosclerotic plaques. These novel trifunctional SV40-based nanoparticles enca...