The intra-molecular NTD–RdRP interface and an open-conformation NS5B structure derived from the interface mutations.By solving 2.1–2.5 A resolution crystal structures of the classical swine fever virus (CSFV) NS5B, an RdRP with a unique naturally fused N-terminal domain (NTD), the research group led by Prof. GONG Peng in Wuhan Institute of Virology of the Chinese Academy of Sciences identifie...
Dental caries is a common disease caused by oral bacteria. Streptococcus mutans and Streptococcus sobrinus are the primary cariogenic microbes that often survive as biofilms on teeth. In a recent study, we the research group led by Prof. WEI Hongping in Wuhan Institute of Virology of the Chinese Academy of Sciences evaluated the activity of ClyR, a well-known chimeric lysin with extended strept...
New anti‐infective approaches are much needed to control multi‐drug‐resistant (MDR) pathogens, such as methicillin‐resistant Staphylococcus aureus (MRSA). In a recent study, the research group led by Prof. WEI Hongping in Wuhan Institute of Virology of the Chinese Academy of Sciences found for the first time that a recombinant protein derived from the cell wall binding domain (CBD) of the b...
Viruses with filamentous morphologies, such as tobacco mosaic virus (TMV) and M13 bacteriophage, have long been studied as multivalent nanoscaffolds for loading functional motifs. Structural assembly of the capsid proteins (CPs) of filamentous viruses often requires the presence of DNA or RNA molecules, which has limited their applications.
