Chemical modifications of RNA are critical for RNA metabolism, function, and localization. One of the most abundant internal RNA modifications is N6-methyladenosine (m6A). It has been previously reported that viral RNA contains internal m6A modifications. However, only recently the function of m6A began to be unraveled during virus infections of HIV, hepatitis C virus and Zika virus.
Human bocavirus (HBoV) was first identified in 2005. HBoV1 infection leads to various clinical manifestations such as pneumonia, bronchiolitis and acute otitis media, which can be life-threatening. The capsid mRNA transcripts of HBoV1 can be generated by alternative splicing from the mRNA precursor transcribed from the P5 promoter. However, the detailed mechanism that regulates the alternative ...
The intra-molecular NTD–RdRP interface and an open-conformation NS5B structure derived from the interface mutations.By solving 2.1–2.5 A resolution crystal structures of the classical swine fever virus (CSFV) NS5B, an RdRP with a unique naturally fused N-terminal domain (NTD), the research group led by Prof. GONG Peng in Wuhan Institute of Virology of the Chinese Academy of Sciences identifie...
Dental caries is a common disease caused by oral bacteria. Streptococcus mutans and Streptococcus sobrinus are the primary cariogenic microbes that often survive as biofilms on teeth. In a recent study, we the research group led by Prof. WEI Hongping in Wuhan Institute of Virology of the Chinese Academy of Sciences evaluated the activity of ClyR, a well-known chimeric lysin with extended strept...
