Research Progress

[17-12-2018]Scientists constructed three human IgG1 Fc mutants for better clinical performance

Fc-based therapeutic proteins include therapeutic antibodies and Fc-fusion proteins. Therapeutic monoclonal antibodies (mAbs) with high affinity and specificity are now widely used in treatment of cancer, immune disorders, viral infection and other diseases. Fc-fusion proteins are also emerging as promising biopharmaceuticals because of the additional benefits from Fc fragment.

[16-11-2018]Scientists constructed a type of QD-encapsulated virus particle

Labeling and imaging with quantum dots (QDs) provides powerful tools to visualize viral infection in living cells. Encapsulating QDs within virions represents a novel strategy for virus labeling. In a present study, the research group led by Prof. CUI Zongqiang in Wuhan Institute of virology of Chinese Academy of sciences developed infectious HIV-1 virions encapsulating QDs through site-specifi...

[06-11-2018]EV71 RNA contains m6A modifications that play a critical role in viral replication

Chemical modifications of RNA are critical for RNA metabolism, function, and localization. One of the most abundant internal RNA modifications is N6-methyladenosine (m6A). It has been previously reported that viral RNA contains internal m6A modifications. However, only recently the function of m6A began to be unraveled during virus infections of HIV, hepatitis C virus and Zika virus.

[05-11-2018]UATGs play an important role in the viral life cycle

Human bocavirus (HBoV) was first identified in 2005. HBoV1 infection leads to various clinical manifestations such as pneumonia, bronchiolitis and acute otitis media, which can be life-threatening. The capsid mRNA transcripts of HBoV1 can be generated by alternative splicing from the mRNA precursor transcribed from the P5 promoter. However, the detailed mechanism that regulates the alternative ...