During virus infection, uncoating is a key step to release the viral genome into host cells, and this step is an attractive antiviral target. However, virus uncoating, especially influenza A virus (IAV), which contains an unusual genome of eight segmented RNAs, has been a poorly understood process due to limitation in applicable methodology for detecting this transient and dynamic event.
Filoviruses, especially Ebola virus (EBOV) and Marburg virus (MARV), are notoriously pathogenic and capable of causing severe hemorrhagic fever diseases in humans with high lethality. The risk of future outbreaks of filoviruses is drawing increasing concern as other bat-borne filoviruses such as Lloviu virus and Bombali virus were globally discovered with great genetic diversity.
Fc-based therapeutic proteins include therapeutic antibodies and Fc-fusion proteins. Therapeutic monoclonal antibodies (mAbs) with high affinity and specificity are now widely used in treatment of cancer, immune disorders, viral infection and other diseases. Fc-fusion proteins are also emerging as promising biopharmaceuticals because of the additional benefits from Fc fragment.
Labeling and imaging with quantum dots (QDs) provides powerful tools to visualize viral infection in living cells. Encapsulating QDs within virions represents a novel strategy for virus labeling. In a present study, the research group led by Prof. CUI Zongqiang in Wuhan Institute of virology of Chinese Academy of sciences developed infectious HIV-1 virions encapsulating QDs through site-specifi...
