Prion protein (PrP) is a glycosylphosphatidylinositol anchored protein widely expressed in central nervous system, lymphoreticular system and GI tract. It has been attributed to neurodegenerative diseases such as prion disease and alzheimers disease. However, normal functions of PrP remains in-completely understood.
Herpes simplex virus (HSV) is a prevalent worldwide human pathogen that infects epithelial cells before it establishes latency in trigeminal or sacral nerve root ganglia, causing mucocutaneous lesions, keratitis, and encephalitis. The development of vaccines and novel therapeutic strategies against HSV has become very urgent.
Ebola virus (EBOV) is one of the most virulent pathogens to humans. Recently, the largest-ever outbreak of Ebola virus disease (EVD) in West Africa, 2013–2016, resulted in the unprecedented damage to human health and social economy. However, there is currently no licensed vaccine or antiviral available against EVD. Clinically, EBOV infection can result in exaggerated inflammatory responses and...
Sulfhydryl oxidase catalyzes disulfide bond formation of substrate proteins. P33, a baculovirus-encoded sulfhydryl oxidase, is different from other cellular and viral sulfhydryl oxidases, bearing unique features in tertiary and quaternary structure organizations. To better understand the structural and functional relationship of P33, a series of point mutations in three conserved regions were g...
