In baculovirus, a large double stranded enveloped DNA virus, so far only a single protein, named GP41, has been identified as an O-glycosylated tegument protein. Baculoviruses are specific for insects and have been widely used as biocontrol agents of insect pests, as well as efficient gene expression and gene delivery vectors for human therapy. GP41 was originally identified as an O-linked glyc...
Human cytomegalovirus (HCMV) has a large (~235-kb) genome with over 170 ORFs and exploits numerous cellular factors to facilitate its replication. HCMV infection increases protein levels of WD repeat-containing protein 5 (WDR5) during infection, overexpression of WDR5 enhances viral replication, and knockdown of WDR5 dramatically attenuates viral replication. WDR5 is essential for assembling th...
A research group from Wuhan Institute of Virology, Chinese Academy of Sciences, announced that they have developed a new type of flu vaccine using nano-technology. The intranasal nano-vaccine can target broad-spectrum flu viruses and induces robust immune responses, said Cui Zongqiang, leader of the research group.
Noroviruses are a genetically diverse group of non-enveloped, positive-stranded RNA viruses belonging to genus Norovirus of the family Caliciviridae. They arefurther segregated into seven genogroups (GI-GVII), three of which cause diseases exclusively in humans (GI, GII, and GIV). Human noroviruses (HuNoVs) are now considered the leading cause of viral gastroenteritis in humans across the globe...
