Ebola virus (EBOV) is one of the most virulent pathogens to humans. Recently, the largest-ever outbreak of Ebola virus disease (EVD) in West Africa, 2013–2016, resulted in the unprecedented damage to human health and social economy. However, there is currently no licensed vaccine or antiviral available against EVD. Clinically, EBOV infection can result in exaggerated inflammatory responses and...
Sulfhydryl oxidase catalyzes disulfide bond formation of substrate proteins. P33, a baculovirus-encoded sulfhydryl oxidase, is different from other cellular and viral sulfhydryl oxidases, bearing unique features in tertiary and quaternary structure organizations. To better understand the structural and functional relationship of P33, a series of point mutations in three conserved regions were g...
Prion protein (PrP) is up-regulated in many cell types upon cellular activation or viral infection. However, the physiological consequences of PrP up-regulation remain incompletely understood. In a present study, the research group led by Prof. LI Chaoyang from Wuhan Institute of Virology of the Chinese Academy of Sciences found that when M2 cells were stimulated with TNFα, the TNFR signaling ...
Dental caries, one of the most common global chronic diseases distributed unevenly among populations, is still a major oral health problem in most industrialized countries. It affects 60–90% of school-age children and the vast majority of adults, thus an anti-caries vaccine has long been attractive for broad-based dental health in caries prevention, and in the treatment of large infected popul...
