Research Progress

[17-08-2016]Chinese Researchers Reveal the Role of a Redox Sensor Protein in Virulence and Intracellular Surv...

A new research report appearing on August 30th 2016 in Cell Reports dissects the cellular role of WhiB6, one of the WhiB redox sensor family proteins, in virulence and intracellular survival of pathogenic mycobacteria, according to researchers from the Center for Emerging Infectious Diseases, Wuhan Institute of Virology (WIV), Chinese Academy of Sciences (CAS).

[01-08-2016]RpoS-dependent sRNA RgsA regulates Fis and AcpP in Pseudomonas aeruginosa

RgsA is a phylogenetically conserved small regulatory RNA (sRNA) in Pseudomonas species. This sRNA has been shown to be directly controlled by the major stationary phase and stress sigma factor σS (RpoS), and also indirectly regulated by the GacS/GacA two-component system. However, the role and the regulatory targets of this sRNA remain unclear. Here, the research group led by Professor Shiyun...

[01-08-2016]Scientists in WIV Observed the Sequential Disassembly Process of Single HIV-1 Virus Particles in ...

On June 2nd 2016, the study jointly developed by the research teams led by Professor Zongqiang Cui in WIV, Professor Xianen Zhang in Institute of Biophysics, CAS and Professor Zhike He in Wuhan University was published online by the ACS Nano journal. The research paper (DOI: 10.1021/acsnano.6b02462) first demonstrates the real-time imaging of single HIV-1 disassembly with multicolor viral parti...

[01-08-2016]WIV First Illustrated a Mechanism for σE in Response to Oxidative Stress through Regulation of r...

Mycobacterium tuberculosis adopts various strategies to cope with oxidative stress during infection. Transcriptional regulators, including σ factors, make important contributions to this stress response, but how these proteins cooperate with each other is largely unknown. In the study (DOI: 10.1111/mmi.13449), the role of RbpA and its cooperation with σ factors in response to oxidative stress...