Multiple infections of avian influenza viruses (AIVs) in poultry or wild birds contribute to the continued evolution of H5 subtype viruses in nature and provide potential recombination of AIVs of different origins. In this study, by collaboration with Prof. Qiyun Zhu in Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences and Prof. Hualan Chen in Harbin Veterinary Res...
Flavivirus nonstructural protein 2B (NS2B) is a transmembrane protein that functions as a cofactor for viral NS3 protease. The cytoplasmic region (amino acids 51-95) alone of NS2B is sufficient for the NS3 protease activity, whereas the role of transmembrane domains (TMDs) remains obscure. The Research Group of Flavivirus Infection, led by Prof. Bo Zhang demonstrates for the first time, that fl...
One of the most common protein post-translational modifications is N-linked glycosylation. N-linked glycosylation is important in proper protein folding, transit to the cell surface and secretion, in a protein, as well as cell context dependent manner. The normal cellular prion protein, PrP, is a widely expressed, highly conserved, glycosylphosphatidylinositol (GPI)-anchored cell surface glyco...
By cooperation with Shenzhen Entry-Exit Inspection and Quarantine Bureau, scientists from WIV have isolated one Zika virus strain, which will assist scientists study the transmission pattern of the virus while provide a foundation for the invention of reagent and vaccine.
