Mycobacterium tuberculosis adopts various strategies to cope with oxidative stress during infection. Transcriptional regulators, including σ factors, make important contributions to this stress response, but how these proteins cooperate with each other is largely unknown. In the study (DOI: 10.1111/mmi.13449), the role of RbpA and its cooperation with σ factors in response to oxidative stress...
Human bocavirus (HBoV), a parvovirus, is a single-stranded DNA etiologic agent causing lower respiratory tract infections in young children worldwide. Nuclear factor kappa B (NF-κB) transcription factors play crucial roles in clearance of invading viruses through activation of many physiological processes. Previous investigation showed that HBoV infection could significantly upregulate the lev...
Multiple infections of avian influenza viruses (AIVs) in poultry or wild birds contribute to the continued evolution of H5 subtype viruses in nature and provide potential recombination of AIVs of different origins. In this study, by collaboration with Prof. Qiyun Zhu in Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences and Prof. Hualan Chen in Harbin Veterinary Res...
Flavivirus nonstructural protein 2B (NS2B) is a transmembrane protein that functions as a cofactor for viral NS3 protease. The cytoplasmic region (amino acids 51-95) alone of NS2B is sufficient for the NS3 protease activity, whereas the role of transmembrane domains (TMDs) remains obscure. The Research Group of Flavivirus Infection, led by Prof. Bo Zhang demonstrates for the first time, that fl...
