Research Progress

[01-08-2016]Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting...

Human bocavirus (HBoV), a parvovirus, is a single-stranded DNA etiologic agent causing lower respiratory tract infections in young children worldwide. Nuclear factor kappa B (NF-κB) transcription factors play crucial roles in clearance of invading viruses through activation of many physiological processes. Previous investigation showed that HBoV infection could significantly upregulate the lev...

[02-06-2016]Scientist in WIV achieves a progress in study on reassortment of influenza viruses

Multiple infections of avian influenza viruses (AIVs) in poultry or wild birds contribute to the continued evolution of H5 subtype viruses in nature and provide potential recombination of AIVs of different origins. In this study, by collaboration with Prof. Qiyun Zhu in Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences and Prof. Hualan Chen in Harbin Veterinary Res...

[02-06-2016]A new function of flavivirus NS2B in virion assembly is uncovered

Flavivirus nonstructural protein 2B (NS2B) is a transmembrane protein that functions as a cofactor for viral NS3 protease. The cytoplasmic region (amino acids 51-95) alone of NS2B is sufficient for the NS3 protease activity, whereas the role of transmembrane domains (TMDs) remains obscure. The Research Group of Flavivirus Infection, led by Prof. Bo Zhang demonstrates for the first time, that fl...

[02-06-2016]Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan

One of the most common protein post-translational modifications is N-linked glycosylation. N-linked glycosylation is important in proper protein folding, transit to the cell surface and secretion, in a protein, as well as cell context dependent manner. The normal cellular prion protein, PrP, is a widely expressed, highly conserved, glycosylphosphatidylinositol (GPI)-anchored cell surface glyco...